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The map label for this gene is murC

Identifier: 21672874

GI number: 21672874

Start: 29087

End: 30514

Strand: Reverse

Name: murC

Synonym: CT0033

Alternate gene names: 21672874

Gene position: 30514-29087 (Counterclockwise)

Preceding gene: 21672875

Following gene: 21672873

Centisome position: 1.42

GC content: 64.36

Gene sequence:

>1428_bases
GTGCCCCCCATGGAACTGGGAAAAACAAAGAATGTGCATATCGTCGGCATCGGCGGCGCGGGAATGAGCGCCATCGCCGA
ACTGCTGCTGAAATCGGGATTCGCGGTCAGCGGCTCTGACCTGGCCTCAGGCGAGGTGATCGACAAGCTTCGTGAGCTTG
GCGCGGTAATCCATCAGGGGCACCAGGCCGAAAATGTCGGCGCGAGCGACGTTGTCGTCTACTCCTCGGCAGTGCGTCCC
GAGAGCAACGTCGAAATTCTCGCCGCGCAGAAGCTCGGCATTCCGGTCATCAAGCGCGACGAAATGCTCGGCGAGCTGAT
GCGCCACAAATCGGGCATCTGCGTCTCGGGCACCCACGGCAAGACCACCACGACCGCAATGGTCGCAACCATGCTGCTCG
AAGCGGGCCAGTCGCCGACAGTGATGATCGGCGGCGTGTCGGACTACCTCAAGGGAAGCACGGTGGTCGGCGAGGGCAAG
TCCATGGTGATCGAGGCCGACGAGTACGACCGCGCGTTCCTCAAGCTCACGCCGACCATAGCCGTCCTGAACAGCCTCGA
ATCGGAGCACATGGACACCTACGGCACGATGGACAACCTGCGCGACTGCTTCGCGGAGTTCGCCAATAAGGTGCCGTTTT
ACGGGCGGGTCATCTGCTGCGTTGACTGGCCGGAGATCCGGCGTATCATTCCCCGGCTGAATCGCCGCTACACTACCTTC
GGCATCGAGGAGCACGCCGATGTGATGGCTTCGGAGATCGAACCCGGCGATGGGGGCAGCACCTTTACCGTCGAGGCGTT
CGGCGAGCGCTACCCCGGCGTACGGCTCAACGTGCCCGGCAGGCATAACGTGCTCAACGCGCTGGCGGCCTTCTCGGTCG
GCCTCGAAATCGGCCTGCCGCCGGAGCGGATCATCGCTGGCCTGGCCAGGTACAGCGGAATGCGCCGCCGCTTCCAGGTC
AAGTACCGGGGCGCTGACGGCGTGCTCGTCATCGACGATTACGCGCATCACCCCACCGAGGTGAAGGCGACCGTCCGGGC
AGCCCGCGACGGATGGAAAGAGCACCGCATCGTGGCGGTTTTCCAGCCGCATCTTTACTCGCGGACGGCGGAGTTCGCCG
GTGAGTTCGGCTGGGCGCTCTCCCGCGCCGACACGGTTTACGTGGCGGGCATCTACCCGTCGCGCGAGAAGGCCGAGGAC
TATCCCGGTATCACCGGCGAGTTGGTGGCCGAAGCATCGAGAACCGCCGGGGCGAAAAACGTATGGTTCACCGAAGAGCA
CGAAGCGCTGCTCGCGGCGCTTCAGGAGGAGGCCGCGCCGGAGACGCTTTTCCTCTTCATGGGGGCGGGCGACATCACGC
ATCTGGCCGCGCGATTCGCCGCATGGTGCACGGAGATGCGCAGCAACGCAGACGCAACGGCGTCATGA

Upstream 100 bases:

>100_bases
GAAACTCGCGCAAATGGGCGAGGCGGCCCGGCGAGAGGGTCATCCCGGCGCGGCGGCGACACTCGCGGAAAGAATCATCG
CGCTATCAAAATCATAAGGA

Downstream 100 bases:

>100_bases
TCTCCGCCGTTGACTGGCATAACAGGAGCAACAAGTATGGCTCGTCCGAAACATGAACAGCGGAGCGAGGAACTGCGTCA
AGATCCGGCGCTGCCGGACC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MPPMELGKTKNVHIVGIGGAGMSAIAELLLKSGFAVSGSDLASGEVIDKLRELGAVIHQGHQAENVGASDVVVYSSAVRP
ESNVEILAAQKLGIPVIKRDEMLGELMRHKSGICVSGTHGKTTTTAMVATMLLEAGQSPTVMIGGVSDYLKGSTVVGEGK
SMVIEADEYDRAFLKLTPTIAVLNSLESEHMDTYGTMDNLRDCFAEFANKVPFYGRVICCVDWPEIRRIIPRLNRRYTTF
GIEEHADVMASEIEPGDGGSTFTVEAFGERYPGVRLNVPGRHNVLNALAAFSVGLEIGLPPERIIAGLARYSGMRRRFQV
KYRGADGVLVIDDYAHHPTEVKATVRAARDGWKEHRIVAVFQPHLYSRTAEFAGEFGWALSRADTVYVAGIYPSREKAED
YPGITGELVAEASRTAGAKNVWFTEEHEALLAALQEEAAPETLFLFMGAGDITHLAARFAAWCTEMRSNADATAS

Sequences:

>Translated_475_residues
MPPMELGKTKNVHIVGIGGAGMSAIAELLLKSGFAVSGSDLASGEVIDKLRELGAVIHQGHQAENVGASDVVVYSSAVRP
ESNVEILAAQKLGIPVIKRDEMLGELMRHKSGICVSGTHGKTTTTAMVATMLLEAGQSPTVMIGGVSDYLKGSTVVGEGK
SMVIEADEYDRAFLKLTPTIAVLNSLESEHMDTYGTMDNLRDCFAEFANKVPFYGRVICCVDWPEIRRIIPRLNRRYTTF
GIEEHADVMASEIEPGDGGSTFTVEAFGERYPGVRLNVPGRHNVLNALAAFSVGLEIGLPPERIIAGLARYSGMRRRFQV
KYRGADGVLVIDDYAHHPTEVKATVRAARDGWKEHRIVAVFQPHLYSRTAEFAGEFGWALSRADTVYVAGIYPSREKAED
YPGITGELVAEASRTAGAKNVWFTEEHEALLAALQEEAAPETLFLFMGAGDITHLAARFAAWCTEMRSNADATAS
>Mature_474_residues
PPMELGKTKNVHIVGIGGAGMSAIAELLLKSGFAVSGSDLASGEVIDKLRELGAVIHQGHQAENVGASDVVVYSSAVRPE
SNVEILAAQKLGIPVIKRDEMLGELMRHKSGICVSGTHGKTTTTAMVATMLLEAGQSPTVMIGGVSDYLKGSTVVGEGKS
MVIEADEYDRAFLKLTPTIAVLNSLESEHMDTYGTMDNLRDCFAEFANKVPFYGRVICCVDWPEIRRIIPRLNRRYTTFG
IEEHADVMASEIEPGDGGSTFTVEAFGERYPGVRLNVPGRHNVLNALAAFSVGLEIGLPPERIIAGLARYSGMRRRFQVK
YRGADGVLVIDDYAHHPTEVKATVRAARDGWKEHRIVAVFQPHLYSRTAEFAGEFGWALSRADTVYVAGIYPSREKAEDY
PGITGELVAEASRTAGAKNVWFTEEHEALLAALQEEAAPETLFLFMGAGDITHLAARFAAWCTEMRSNADATAS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=465, Percent_Identity=40, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1790680, Length=397, Percent_Identity=30.4785894206549, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CHLTE (Q8KGD5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660939.1
- ProteinModelPortal:   Q8KGD5
- SMR:   Q8KGD5
- GeneID:   1006451
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0033
- NMPDR:   fig|194439.1.peg.33
- TIGR:   CT0033
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   CTEP194439:CT_0033-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51465; Mature: 51334

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPMELGKTKNVHIVGIGGAGMSAIAELLLKSGFAVSGSDLASGEVIDKLRELGAVIHQG
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
HQAENVGASDVVVYSSAVRPESNVEILAAQKLGIPVIKRDEMLGELMRHKSGICVSGTHG
CCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHCCCCEEECCCC
KTTTTAMVATMLLEAGQSPTVMIGGVSDYLKGSTVVGEGKSMVIEADEYDRAFLKLTPTI
CHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCEEEECCCEEEEECCCCCCEEEEECHHH
AVLNSLESEHMDTYGTMDNLRDCFAEFANKVPFYGRVICCVDWPEIRRIIPRLNRRYTTF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEEC
GIEEHADVMASEIEPGDGGSTFTVEAFGERYPGVRLNVPGRHNVLNALAAFSVGLEIGLP
CCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
PERIIAGLARYSGMRRRFQVKYRGADGVLVIDDYAHHPTEVKATVRAARDGWKEHRIVAV
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCEEEEE
FQPHLYSRTAEFAGEFGWALSRADTVYVAGIYPSREKAEDYPGITGELVAEASRTAGAKN
ECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCCCC
VWFTEEHEALLAALQEEAAPETLFLFMGAGDITHLAARFAAWCTEMRSNADATAS
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PPMELGKTKNVHIVGIGGAGMSAIAELLLKSGFAVSGSDLASGEVIDKLRELGAVIHQG
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
HQAENVGASDVVVYSSAVRPESNVEILAAQKLGIPVIKRDEMLGELMRHKSGICVSGTHG
CCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHCCCCEEECCCC
KTTTTAMVATMLLEAGQSPTVMIGGVSDYLKGSTVVGEGKSMVIEADEYDRAFLKLTPTI
CHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCEEEECCCEEEEECCCCCCEEEEECHHH
AVLNSLESEHMDTYGTMDNLRDCFAEFANKVPFYGRVICCVDWPEIRRIIPRLNRRYTTF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEEC
GIEEHADVMASEIEPGDGGSTFTVEAFGERYPGVRLNVPGRHNVLNALAAFSVGLEIGLP
CCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
PERIIAGLARYSGMRRRFQVKYRGADGVLVIDDYAHHPTEVKATVRAARDGWKEHRIVAV
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCEEEEE
FQPHLYSRTAEFAGEFGWALSRADTVYVAGIYPSREKAEDYPGITGELVAEASRTAGAKN
ECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCCCC
VWFTEEHEALLAALQEEAAPETLFLFMGAGDITHLAARFAAWCTEMRSNADATAS
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901