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The map label for this gene is trpS [H]

Identifier: 21672854

GI number: 21672854

Start: 11570

End: 12604

Strand: Direct

Name: trpS [H]

Synonym: CT0013

Alternate gene names: 21672854

Gene position: 11570-12604 (Clockwise)

Preceding gene: 21672853

Following gene: 21672855

Centisome position: 0.54

GC content: 59.03

Gene sequence:

>1035_bases
ATGTCGACACAAAGGATTTTAAGCGGGATGCGGCCTACCGGCAAGCTGCACCTCGGTCACTACACCGGAGCACTTGAAAA
TTGGATCGCGCAGCAGAACCTTCTCCATCCCGACGGAAGCCGTGCTTACGAGACCTGCTTTCTGATCGCTGACTACCACA
GCCTGACCACTTCGCTCGATACGTCGAGCCTGTATGCGCACTCCATCGACATGCTTGTCGACTGGCTGGCGGCGGGAGTT
GATCCCGAAAAAAGCCTGGTGTTCCGGCAGTCGCAGGTCAAGGAGCACGCCGAGCTGTTCCTGCTCTTCTCAATGCTCAT
CACCACCGCACGTCTCGAACGCAATCCGACGCTCAAGGAGCAGGTGCGCGACCTGAACATGGACTCGCTCGTGTACGGCC
ACCTCGGCTATCCGGTGTTGCAGGCGGCGGACATTTTGCTCTACAAGGGCAACGTGGTGCCGGTTGGCGAGGATCAGATT
CCGCACGTCGAGATCACCCGCGAGATCGCCCGCAAGTTCAACAGCCACTACCAGCATCCGGAGCTGGGCGACGTCTTCCC
CGAACCCGCACCGAAGATCACGAAGTTCGCGCGTCTGGTCGGTCTGGACGGCAAGGCGAAGATGTCCAAGTCGCTCGGTA
ACACCATTCTGCTTTCGGATGCTCCCGAAGAGGTGATGGCGAAGATGCGCCCCGCCGTGACCGACACGCAGAAGGTGCGC
CGCAACGATCCTGGTCGTCCCGAGGTGTGCCTGGTCTACAGCTATCACCAGAAGTTTACCGGCGAATCGCAGCTTGTCGA
AATCGAGACCGGATGCCGCTCGGGCGCACTCGGCTGCGTCGATTGCAAGAAGATGTGCGCGGCGAACATTTCGGCGGAGC
TGGCTCCGATTCTCGAACGGCGCAAGCACTACGAAGCACAGCCTGAGCTGGTCAAAGAGATTCTGTACGAAGGTGAATCC
AAAGCGAGAAAGATTGCCGGAGAAACCATGAAAGAGGTCAGAGAGGCGATGAGCCTCGGGGAGAGCAACGCATGA

Upstream 100 bases:

>100_bases
TCGCCCGACTGCGTCGGACTCGGAATGACAAGAGAGAAAATACAACCCGCCATAACTATCATAGAGATTCCCTGCAAAAC
AGGAGCAACAAACCCGACCC

Downstream 100 bases:

>100_bases
TGATACAAAACGATACCAAGCCGAAAGCCTTCATTTTCGACATGGACGGCGTGCTGGTCGATAACATGAGAATGCACGCA
CAGTCGTGGGTCGATCTGTT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSTQRILSGMRPTGKLHLGHYTGALENWIAQQNLLHPDGSRAYETCFLIADYHSLTTSLDTSSLYAHSIDMLVDWLAAGV
DPEKSLVFRQSQVKEHAELFLLFSMLITTARLERNPTLKEQVRDLNMDSLVYGHLGYPVLQAADILLYKGNVVPVGEDQI
PHVEITREIARKFNSHYQHPELGDVFPEPAPKITKFARLVGLDGKAKMSKSLGNTILLSDAPEEVMAKMRPAVTDTQKVR
RNDPGRPEVCLVYSYHQKFTGESQLVEIETGCRSGALGCVDCKKMCAANISAELAPILERRKHYEAQPELVKEILYEGES
KARKIAGETMKEVREAMSLGESNA

Sequences:

>Translated_344_residues
MSTQRILSGMRPTGKLHLGHYTGALENWIAQQNLLHPDGSRAYETCFLIADYHSLTTSLDTSSLYAHSIDMLVDWLAAGV
DPEKSLVFRQSQVKEHAELFLLFSMLITTARLERNPTLKEQVRDLNMDSLVYGHLGYPVLQAADILLYKGNVVPVGEDQI
PHVEITREIARKFNSHYQHPELGDVFPEPAPKITKFARLVGLDGKAKMSKSLGNTILLSDAPEEVMAKMRPAVTDTQKVR
RNDPGRPEVCLVYSYHQKFTGESQLVEIETGCRSGALGCVDCKKMCAANISAELAPILERRKHYEAQPELVKEILYEGES
KARKIAGETMKEVREAMSLGESNA
>Mature_343_residues
STQRILSGMRPTGKLHLGHYTGALENWIAQQNLLHPDGSRAYETCFLIADYHSLTTSLDTSSLYAHSIDMLVDWLAAGVD
PEKSLVFRQSQVKEHAELFLLFSMLITTARLERNPTLKEQVRDLNMDSLVYGHLGYPVLQAADILLYKGNVVPVGEDQIP
HVEITREIARKFNSHYQHPELGDVFPEPAPKITKFARLVGLDGKAKMSKSLGNTILLSDAPEEVMAKMRPAVTDTQKVRR
NDPGRPEVCLVYSYHQKFTGESQLVEIETGCRSGALGCVDCKKMCAANISAELAPILERRKHYEAQPELVKEILYEGESK
ARKIAGETMKEVREAMSLGESNA

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=340, Percent_Identity=37.0588235294118, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI41352700, Length=189, Percent_Identity=42.3280423280423, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1789786, Length=347, Percent_Identity=33.7175792507205, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71982800, Length=341, Percent_Identity=30.4985337243402, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982793, Length=341, Percent_Identity=30.4985337243402, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320474, Length=368, Percent_Identity=30.9782608695652, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24666151, Length=347, Percent_Identity=35.7348703170029, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38410; Mature: 38278

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQRILSGMRPTGKLHLGHYTGALENWIAQQNLLHPDGSRAYETCFLIADYHSLTTSLD
CCHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEHHHHHHCCC
TSSLYAHSIDMLVDWLAAGVDPEKSLVFRQSQVKEHAELFLLFSMLITTARLERNPTLKE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
QVRDLNMDSLVYGHLGYPVLQAADILLYKGNVVPVGEDQIPHVEITREIARKFNSHYQHP
HHHHCCHHHEEHHHCCCHHHHHHHEEEECCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
ELGDVFPEPAPKITKFARLVGLDGKAKMSKSLGNTILLSDAPEEVMAKMRPAVTDTQKVR
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHHHHHCCCCCHHHHHH
RNDPGRPEVCLVYSYHQKFTGESQLVEIETGCRSGALGCVDCKKMCAANISAELAPILER
CCCCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
RKHYEAQPELVKEILYEGESKARKIAGETMKEVREAMSLGESNA
HHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STQRILSGMRPTGKLHLGHYTGALENWIAQQNLLHPDGSRAYETCFLIADYHSLTTSLD
CHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEHHHHHHCCC
TSSLYAHSIDMLVDWLAAGVDPEKSLVFRQSQVKEHAELFLLFSMLITTARLERNPTLKE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
QVRDLNMDSLVYGHLGYPVLQAADILLYKGNVVPVGEDQIPHVEITREIARKFNSHYQHP
HHHHCCHHHEEHHHCCCHHHHHHHEEEECCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
ELGDVFPEPAPKITKFARLVGLDGKAKMSKSLGNTILLSDAPEEVMAKMRPAVTDTQKVR
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHHHHHCCCCCHHHHHH
RNDPGRPEVCLVYSYHQKFTGESQLVEIETGCRSGALGCVDCKKMCAANISAELAPILER
CCCCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
RKHYEAQPELVKEILYEGESKARKIAGETMKEVREAMSLGESNA
HHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]