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The map label for this gene is dxs

Identifier: 21672713

GI number: 21672713

Start: 509785

End: 511542

Strand: Reverse

Name: dxs

Synonym: BUsg448

Alternate gene names: 21672713

Gene position: 511542-509785 (Counterclockwise)

Preceding gene: 21672714

Following gene: 21672706

Centisome position: 79.75

GC content: 30.77

Gene sequence:

>1758_bases
ATGAATTTTGACATTACAAGATATCCAATTTTATCTTTTGCTCATTCAGTAAGACGTTTACGACTTTTATCGATTGAACA
ACTACCACAATTATGCACAGAATTACGAAAATATTTATTGGATGTAGTTTCTATTACTCAAGGACATTTTGCTTCTGGAT
TAGGTGTCATCGAAATTACCGTTGCCTTGCATTATGTTTATGATACTCCTTTTGACAATTTATTGTGGGATGTAGGACAT
CAATCTTATCCGCATAAAATATTGACAGGAAGAGCTGAAAAAATAGGCAGTATCAGAAAGAAAAATGGATTGCATCCCTT
CCCCTTTAGAGAAGAAAGTAAATATGATATTTTAAGTGTTGGACATTCTTCTACTTCAATTAGTGCAGGATTGGGATTGT
CAATTGCAGCTGGAAAAGAGGGAAAAAATAGAAAAACCATTTGTGTTGTTGGTGATGGTTCTATGACTGCAGGTATGGCT
TTTGAAGCTATGAATCATGCTGGTATAATACAATCTGACCTTCTAGTAGTTCTAAATGATAATCAAATGTCTATTTCAAA
AAATATAGGTGCCTTAAATAAACATTTAAAATTTTTAAGAGATATAAAAAAAAGCAGCAAAATTTTTAATTTTTCAATAT
TTGAAAGTTTAAATTTTAAATATTTAGGACCATTTGATGGACACAATATTTTTAAATTGATTGAAATTTTTAAAAAAACA
AAAGATTATAGAAAAACCTGTTTATTGCATTTAATTACTAAAAAAGGAAAAGGTTATCTTCCTGCAGAATTAGATCCAAT
TAAATGGCATACAATATCTCAATCTTTTTCTTCATCTTCTAAAATTCTTACTTATTCAGATGTTTTTGGTTCTTGGTTAT
GCGAAATAGCTGAATTTGATAAAAAAATAATGGCTATCACACCTGCTATGTGTGAAGGTTCGGGAATGCTAAAATTTTCT
CGTCTTTTTCCTAATCAATATTTTGATGTTGCTATTGCTGAGCAACATGCAGTTACTTTTGCAGCTGGTCTAGCTATTGC
AGGATATAAACCTGTTGTATCAATTTATTCTACTTTTCTACAACGTGCTTATGATCAAATTATACATGATGTAGCGTTAC
AAAAATTACCAGTCTTATTTGCTATTGATAGAGGAGGGATAGTAGGACATGACGGTCCAACACATCAAGGAATTTTTGAT
TTGTCTTATTTAAGATGCATTCCTGGCATTGTTATTATGACTCCAAGTAATGAGAATGAATGCAGACAAATGTTGTATAC
AGGATATATGTACAAAGAAGGTCCTAGTGTAGTTAGATATCCTAAAGGCAAAGGTATTGGAATGTCATTATCCCCGATGA
AGCTAATTCCGTTAGGTAAATCTCTTATTAAACGAGTTGGAGAAAAAATAGCTATTTTAAATTTTGGAGCTTTATTGCAA
AATGCTTATTTAGCAGCAGAAAAATTAAATGCTACATTGATTGATATGAGATTTGTTAAACCATTAGATACAAATATGAT
TTTAAAGTTATCATTAAAATATAACTTTTTAGTTACAATTGAAGAGGGTGTTATTGCTGGTGGAGCAGGAAGTGCAGTAA
ATGAGTTTATTATGATGAGGAAAATTTTACTTCCAGTTTTAAATATTGGATTACCTGATATGTTTATTGCTCACGGTAGT
CAGGAAGAGATTAAACATGATTATCAATTAGATCCGGAAGGCATTCAAAACAAAATACTTGCTTGGTTGTCATATTAG

Upstream 100 bases:

>100_bases
ACATTAGAAATTTTAAAAAAAAATTTTAATGTTAATATATTAAAATTACTGACACAGTTTATAATGAAACGTTTTAAATA
AGTTTAAAAATGAGTTTCCA

Downstream 100 bases:

>100_bases
AATAATAAAAATTTTTTAATTATTATTTATCTTTTAATTTTTAATGCTGCTTTATCTAAAACACCATTAATAAACTTATG
ACTATCTTCAGATCCAAATA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEITVALHYVYDTPFDNLLWDVGH
QSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSVGHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMA
FEAMNHAGIIQSDLLVVLNDNQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKT
KDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFDKKIMAITPAMCEGSGMLKFS
RLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFLQRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFD
LSYLRCIPGIVIMTPSNENECRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQ
NAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMRKILLPVLNIGLPDMFIAHGS
QEEIKHDYQLDPEGIQNKILAWLSY

Sequences:

>Translated_585_residues
MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEITVALHYVYDTPFDNLLWDVGH
QSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSVGHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMA
FEAMNHAGIIQSDLLVVLNDNQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKT
KDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFDKKIMAITPAMCEGSGMLKFS
RLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFLQRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFD
LSYLRCIPGIVIMTPSNENECRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQ
NAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMRKILLPVLNIGLPDMFIAHGS
QEEIKHDYQLDPEGIQNKILAWLSY
>Mature_585_residues
MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEITVALHYVYDTPFDNLLWDVGH
QSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSVGHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMA
FEAMNHAGIIQSDLLVVLNDNQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKT
KDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFDKKIMAITPAMCEGSGMLKFS
RLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFLQRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFD
LSYLRCIPGIVIMTPSNENECRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQ
NAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMRKILLPVLNIGLPDMFIAHGS
QEEIKHDYQLDPEGIQNKILAWLSY

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=493, Percent_Identity=22.7180527383367, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4507521, Length=493, Percent_Identity=22.7180527383367, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI156564403, Length=280, Percent_Identity=26.0714285714286, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI291084858, Length=272, Percent_Identity=25, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI133778974, Length=472, Percent_Identity=22.0338983050847, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=60.7085346215781, Blast_Score=798, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538422, Length=311, Percent_Identity=22.508038585209, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=289, Percent_Identity=27.3356401384083, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666278, Length=592, Percent_Identity=24.1554054054054, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645119, Length=492, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551847, Length=581, Percent_Identity=23.7521514629948, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550715, Length=581, Percent_Identity=23.7521514629948, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358145, Length=300, Percent_Identity=25.3333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650940, Length=300, Percent_Identity=25.3333333333333, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BUCAP (Q8K9A1)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660780.1
- ProteinModelPortal:   Q8K9A1
- SMR:   Q8K9A1
- EnsemblBacteria:   EBBUCT00000000295
- GeneID:   1005718
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg448
- GeneTree:   EBGT00050000007697
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- ProtClustDB:   PRK05444
- BioCyc:   BAPH198804:BUSG448-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 65248; Mature: 65248

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEE
VALHYVYDTPFDNLLWDVGHQSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSV
EEEEEEECCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMAFEAMNHAGIIQSDLLVVLND
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEEECC
NQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKT
CCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHH
KDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFD
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEEHHHHHHHHHHHHHHC
KKIMAITPAMCEGSGMLKFSRLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFL
CCEEEECCHHCCCCCCEEEHHHCCCCCEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHH
QRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFDLSYLRCIPGIVIMTPSNENE
HHHHHHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCHHHHHHHHCCCEEEEECCCHHH
CRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQ
HHHHHHHCEEEECCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEEHHHHHH
NAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMR
HHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHHHH
KILLPVLNIGLPDMFIAHGSQEEIKHDYQLDPEGIQNKILAWLSY
HHHHHHHHCCCCHHHEECCCHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFDITRYPILSFAHSVRRLRLLSIEQLPQLCTELRKYLLDVVSITQGHFASGLGVIEIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEE
VALHYVYDTPFDNLLWDVGHQSYPHKILTGRAEKIGSIRKKNGLHPFPFREESKYDILSV
EEEEEEECCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAGLGLSIAAGKEGKNRKTICVVGDGSMTAGMAFEAMNHAGIIQSDLLVVLND
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEEECC
NQMSISKNIGALNKHLKFLRDIKKSSKIFNFSIFESLNFKYLGPFDGHNIFKLIEIFKKT
CCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHH
KDYRKTCLLHLITKKGKGYLPAELDPIKWHTISQSFSSSSKILTYSDVFGSWLCEIAEFD
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEEHHHHHHHHHHHHHHC
KKIMAITPAMCEGSGMLKFSRLFPNQYFDVAIAEQHAVTFAAGLAIAGYKPVVSIYSTFL
CCEEEECCHHCCCCCCEEEHHHCCCCCEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHH
QRAYDQIIHDVALQKLPVLFAIDRGGIVGHDGPTHQGIFDLSYLRCIPGIVIMTPSNENE
HHHHHHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCHHHHHHHHCCCEEEEECCCHHH
CRQMLYTGYMYKEGPSVVRYPKGKGIGMSLSPMKLIPLGKSLIKRVGEKIAILNFGALLQ
HHHHHHHCEEEECCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEEHHHHHH
NAYLAAEKLNATLIDMRFVKPLDTNMILKLSLKYNFLVTIEEGVIAGGAGSAVNEFIMMR
HHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHHHH
KILLPVLNIGLPDMFIAHGSQEEIKHDYQLDPEGIQNKILAWLSY
HHHHHHHHCCCCHHHEECCCHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438