Click here to switch to the map view.

The map label for this gene is tcyP [H]

Identifier: 213693313

GI number: 213693313

Start: 2787235

End: 2788692

Strand: Direct

Name: tcyP [H]

Synonym: Blon_2467

Alternate gene names: 213693313

Gene position: 2787235-2788692 (Clockwise)

Preceding gene: 213693312

Following gene: 213693319

Centisome position: 98.39

GC content: 64.47

Gene sequence:

>1458_bases
ATGTCCGACATCGCATACGACTGGCTCACTTTGGGTGCGGCCGCCGTCCTATTCGCCATCCTGTCATTCCTCAAACGCAA
GAAGAACGCGGGATTCACCACACGGGTGCTGCTGGCAACGGCATTCGGCGTCGTTCTCGGCATCGCATGCAAAGGCCATA
CCGGGTACGTCGGCGCGGTGGGTTCCATCTGGTCCAGCGTGATCACCGCGCTGGTGGTGCCGCTGCTCGTGTTCAGCATC
ATCTCCAGCATCACCAACCTCGGAGAATCCATCCGATTGAAGAACATCGGCGTGAAGACCGTGTTCTTCCTGCTGCTCAA
CACCACCACCGCCTCACTGCTCACGCTGCTTCTGGCGCAAGCGTTCCAGTTGGGGCGCGGCTTCCACTACACCTTGTCCG
GCGACTACACGCCACACGACGTTCCCGCGGTCCTCGACACCATCGTGAACCTGTTCCCGCGAAACCTCGCGGACAACTGG
GTCAACAACCAGGTGGTGCCCATCGTGCTGTTCGCCATCCTGACCGCACTCGCCTACAACGCCGCCGCCTCCACGGACAA
AGGCCGTTCCGCGGTCGCGCCGTTCAAGACCTTCATCGACGCGGGCAACGTGGTCTTCTCCAAAGCAACCCAAATCGTGG
TCGGATACACCCCGTATGCGGTGCTCGCCCTCATCGCCGAAGCGGTGAGCGGCAGTGATGCGGCCACCCTGCTGCCGCTG
GTGCTCGCCTTGGCCGTCGCCTACATCGCAATCGCCCTGCAGCTGTTCCTGGTGCAGCCGCTTGTGCTCGCGACCGTGAC
GAGACTGAACCCGATCCGATTCTTCAAGGCGTTCTTCCCCGCCGGAGTGGTCGCGTTCACGTCGGAGAGCAGCATCGGCA
CGATTCCCGTCACCGTTCGCCAGCTACGCAGCGCCGGCGTTCCGGGCGACATCGCCTCGTTCGTGGCCGGACTGGGCGCC
AATCTCGGCATGCCCGGATGCGCCGGCGTGTGGCCGATGCTGCTGGCGGTGTTCGCCGTCCACGCTCAGGGACTGAACTA
CTCTCCCGCACAGTATCTGTTCCTCGTGGTGCTCACGCTCCTGGTCTCGATCGGAACCGTGGGCGTGCCCGGCACCGCCA
CCATCACCGCGACCTCGTTGTTCGCCGCCGCCGGCCTGCCGATTCCATTCATCGCCATCAGCCAGCCGATCAGCCAGATC
GTGGATATGGGCCGCACCGCATTGAACGTCGCCGGCGCCGCCAACACCGCGGTGATCGTCGCGCAGACCGAACATCAACT
GGATGCCGACCTGTATTACGGGCGTAAGGAGTATTCCGACGAACTCGACGTCGACGGGTCCGACGCCGGTCCGGCCCCCA
CGCCGACGACGGCACCGGCAGTGCCCCCGCGCCTGCCGAATGCGGTGCTTCTCGCCAGCGGAGGCGACGCCTGCTGCGGC
ATCAGACCCGGCAAGTGA

Upstream 100 bases:

>100_bases
CCACAGGGCGTTGCGTCAACGATGCGACGGATAGATTGATTCCAACATGAAACGGATCGTCCCGCACGGACACATCCTGA
TTTTCAGAGAAGGGAACATC

Downstream 100 bases:

>100_bases
TTAGTATTCAAGATTTGTCGTGCCTCCTGTTCTGTGCCCTGCATGAACAGGCACAGAACAGGAGGCATGGTTTTTCATAT
TCACGGCATTGGCCGTACTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSDIAYDWLTLGAAAVLFAILSFLKRKKNAGFTTRVLLATAFGVVLGIACKGHTGYVGAVGSIWSSVITALVVPLLVFSI
ISSITNLGESIRLKNIGVKTVFFLLLNTTTASLLTLLLAQAFQLGRGFHYTLSGDYTPHDVPAVLDTIVNLFPRNLADNW
VNNQVVPIVLFAILTALAYNAAASTDKGRSAVAPFKTFIDAGNVVFSKATQIVVGYTPYAVLALIAEAVSGSDAATLLPL
VLALAVAYIAIALQLFLVQPLVLATVTRLNPIRFFKAFFPAGVVAFTSESSIGTIPVTVRQLRSAGVPGDIASFVAGLGA
NLGMPGCAGVWPMLLAVFAVHAQGLNYSPAQYLFLVVLTLLVSIGTVGVPGTATITATSLFAAAGLPIPFIAISQPISQI
VDMGRTALNVAGAANTAVIVAQTEHQLDADLYYGRKEYSDELDVDGSDAGPAPTPTTAPAVPPRLPNAVLLASGGDACCG
IRPGK

Sequences:

>Translated_485_residues
MSDIAYDWLTLGAAAVLFAILSFLKRKKNAGFTTRVLLATAFGVVLGIACKGHTGYVGAVGSIWSSVITALVVPLLVFSI
ISSITNLGESIRLKNIGVKTVFFLLLNTTTASLLTLLLAQAFQLGRGFHYTLSGDYTPHDVPAVLDTIVNLFPRNLADNW
VNNQVVPIVLFAILTALAYNAAASTDKGRSAVAPFKTFIDAGNVVFSKATQIVVGYTPYAVLALIAEAVSGSDAATLLPL
VLALAVAYIAIALQLFLVQPLVLATVTRLNPIRFFKAFFPAGVVAFTSESSIGTIPVTVRQLRSAGVPGDIASFVAGLGA
NLGMPGCAGVWPMLLAVFAVHAQGLNYSPAQYLFLVVLTLLVSIGTVGVPGTATITATSLFAAAGLPIPFIAISQPISQI
VDMGRTALNVAGAANTAVIVAQTEHQLDADLYYGRKEYSDELDVDGSDAGPAPTPTTAPAVPPRLPNAVLLASGGDACCG
IRPGK
>Mature_484_residues
SDIAYDWLTLGAAAVLFAILSFLKRKKNAGFTTRVLLATAFGVVLGIACKGHTGYVGAVGSIWSSVITALVVPLLVFSII
SSITNLGESIRLKNIGVKTVFFLLLNTTTASLLTLLLAQAFQLGRGFHYTLSGDYTPHDVPAVLDTIVNLFPRNLADNWV
NNQVVPIVLFAILTALAYNAAASTDKGRSAVAPFKTFIDAGNVVFSKATQIVVGYTPYAVLALIAEAVSGSDAATLLPLV
LALAVAYIAIALQLFLVQPLVLATVTRLNPIRFFKAFFPAGVVAFTSESSIGTIPVTVRQLRSAGVPGDIASFVAGLGAN
LGMPGCAGVWPMLLAVFAVHAQGLNYSPAQYLFLVVLTLLVSIGTVGVPGTATITATSLFAAAGLPIPFIAISQPISQIV
DMGRTALNVAGAANTAVIVAQTEHQLDADLYYGRKEYSDELDVDGSDAGPAPTPTTAPAVPPRLPNAVLLASGGDACCGI
RPGK

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=484, Percent_Identity=22.9338842975207, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI66773030, Length=246, Percent_Identity=28.8617886178862, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI169790839, Length=473, Percent_Identity=22.1987315010571, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI194239697, Length=424, Percent_Identity=22.877358490566, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21314632, Length=436, Percent_Identity=24.7706422018349, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4827012, Length=247, Percent_Identity=27.1255060728745, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI223468566, Length=261, Percent_Identity=26.8199233716475, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI223468564, Length=261, Percent_Identity=26.8199233716475, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI5032093, Length=269, Percent_Identity=27.5092936802974, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790514, Length=438, Percent_Identity=26.9406392694064, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1788024, Length=399, Percent_Identity=30.3258145363409, Blast_Score=132, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=491, Percent_Identity=25.2545824847251, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=467, Percent_Identity=24.8394004282655, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71983099, Length=249, Percent_Identity=27.710843373494, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71983106, Length=249, Percent_Identity=27.710843373494, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193206654, Length=482, Percent_Identity=23.4439834024896, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193206505, Length=422, Percent_Identity=24.1706161137441, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17541374, Length=431, Percent_Identity=22.2737819025522, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583025, Length=435, Percent_Identity=22.9885057471264, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137668, Length=435, Percent_Identity=22.9885057471264, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583023, Length=435, Percent_Identity=22.9885057471264, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 50386; Mature: 50255

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIAYDWLTLGAAAVLFAILSFLKRKKNAGFTTRVLLATAFGVVLGIACKGHTGYVGAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GSIWSSVITALVVPLLVFSIISSITNLGESIRLKNIGVKTVFFLLLNTTTASLLTLLLAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AFQLGRGFHYTLSGDYTPHDVPAVLDTIVNLFPRNLADNWVNNQVVPIVLFAILTALAYN
HHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AAASTDKGRSAVAPFKTFIDAGNVVFSKATQIVVGYTPYAVLALIAEAVSGSDAATLLPL
HHCCCCCCCCHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHH
VLALAVAYIAIALQLFLVQPLVLATVTRLNPIRFFKAFFPAGVVAFTSESSIGTIPVTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
QLRSAGVPGDIASFVAGLGANLGMPGCAGVWPMLLAVFAVHAQGLNYSPAQYLFLVVLTL
HHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVSIGTVGVPGTATITATSLFAAAGLPIPFIAISQPISQIVDMGRTALNVAGAANTAVIV
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEE
AQTEHQLDADLYYGRKEYSDELDVDGSDAGPAPTPTTAPAVPPRLPNAVLLASGGDACCG
EECCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
IRPGK
CCCCC
>Mature Secondary Structure 
SDIAYDWLTLGAAAVLFAILSFLKRKKNAGFTTRVLLATAFGVVLGIACKGHTGYVGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GSIWSSVITALVVPLLVFSIISSITNLGESIRLKNIGVKTVFFLLLNTTTASLLTLLLAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AFQLGRGFHYTLSGDYTPHDVPAVLDTIVNLFPRNLADNWVNNQVVPIVLFAILTALAYN
HHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AAASTDKGRSAVAPFKTFIDAGNVVFSKATQIVVGYTPYAVLALIAEAVSGSDAATLLPL
HHCCCCCCCCHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHH
VLALAVAYIAIALQLFLVQPLVLATVTRLNPIRFFKAFFPAGVVAFTSESSIGTIPVTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
QLRSAGVPGDIASFVAGLGANLGMPGCAGVWPMLLAVFAVHAQGLNYSPAQYLFLVVLTL
HHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVSIGTVGVPGTATITATSLFAAAGLPIPFIAISQPISQIVDMGRTALNVAGAANTAVIV
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEE
AQTEHQLDADLYYGRKEYSDELDVDGSDAGPAPTPTTAPAVPPRLPNAVLLASGGDACCG
EECCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
IRPGK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA