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The map label for this gene is upp [H]

Identifier: 213693213

GI number: 213693213

Start: 2637642

End: 2638283

Strand: Direct

Name: upp [H]

Synonym: Blon_2363

Alternate gene names: 213693213

Gene position: 2637642-2638283 (Clockwise)

Preceding gene: 213693212

Following gene: 213693214

Centisome position: 93.11

GC content: 63.86

Gene sequence:

>642_bases
ATGGAACTTCACGTTTTGAATCATCCGCTGGTCGAGCACAAGCTCACCGTGCTGCGCGACAAGAACACCCCCTCCTCCAT
TTTCCGCGAGCTCGTCTCCGAGCTTGTGATGCTTGAAGCCTACGAGGCCACGCGCAACCTGTCCGTGGTCGCCGCGCCGA
TCGAGACGCCGGTCGCCCCGATGACCGGCAAGAAACTGGCCGAACCCCGTCCGATCATCGTGCCGGTGCTGCGCGCGGGC
CTCGGCATGCTCGACGGCATGACCCGCCTCATGCCCACCGCCGAAGTCGGCTTCCTTGGCATGAAGCGCGACGAGGAGCA
TCCCACCCAGCAGGTGACGTATGCGAACCGTTTGCCCGAGGATCTGTCCGGCCGCCAGTGCTTCCTGATCGATCCGATGC
TCGCCACCGGCGGCACGCTGGTCGCCGCCACGCACTATCTGGCCGAACGCGGCGCCAAGGACGTGACCGCGATCAACATC
ATCGCGGCGCCTGAAGGCATCAAGTACGTCGAGGAGCACATCGACCCGTCCATCGAATTCAAGGTCGTGGTGTGCGCGGT
GGACGAGAAGCTCAACGACAAGTGCTACATCGTGCCGGGTCTGGGCGATGCCGGCGATCGTCTCTACGGCGTCATCGACT
GA

Upstream 100 bases:

>100_bases
ACCGTCGCGGCCCGCAACCGGCGCGTTTCCTCGGACTCCCCTTCACGCCATCAGTCGCCCCGGTTCGTCAGGCCGGGAAT
CATGGGCTAGGCTGGGAGTC

Downstream 100 bases:

>100_bases
CACATGAACATCGACATCGTCTGCGTCGGCCGGATCAAGGAACGGTATCTGACCGACGCCATCGCCGAATATTCCAAGCG
GCTCTCGCGCTACTGCAAGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MELHVLNHPLVEHKLTVLRDKNTPSSIFRELVSELVMLEAYEATRNLSVVAAPIETPVAPMTGKKLAEPRPIIVPVLRAG
LGMLDGMTRLMPTAEVGFLGMKRDEEHPTQQVTYANRLPEDLSGRQCFLIDPMLATGGTLVAATHYLAERGAKDVTAINI
IAAPEGIKYVEEHIDPSIEFKVVVCAVDEKLNDKCYIVPGLGDAGDRLYGVID

Sequences:

>Translated_213_residues
MELHVLNHPLVEHKLTVLRDKNTPSSIFRELVSELVMLEAYEATRNLSVVAAPIETPVAPMTGKKLAEPRPIIVPVLRAG
LGMLDGMTRLMPTAEVGFLGMKRDEEHPTQQVTYANRLPEDLSGRQCFLIDPMLATGGTLVAATHYLAERGAKDVTAINI
IAAPEGIKYVEEHIDPSIEFKVVVCAVDEKLNDKCYIVPGLGDAGDRLYGVID
>Mature_213_residues
MELHVLNHPLVEHKLTVLRDKNTPSSIFRELVSELVMLEAYEATRNLSVVAAPIETPVAPMTGKKLAEPRPIIVPVLRAG
LGMLDGMTRLMPTAEVGFLGMKRDEEHPTQQVTYANRLPEDLSGRQCFLIDPMLATGGTLVAATHYLAERGAKDVTAINI
IAAPEGIKYVEEHIDPSIEFKVVVCAVDEKLNDKCYIVPGLGDAGDRLYGVID

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Escherichia coli, GI87082118, Length=210, Percent_Identity=38.0952380952381, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321920, Length=198, Percent_Identity=34.8484848484849, Blast_Score=103, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358379, Length=152, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550449, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573516, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573514, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573512, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23310; Mature: 23310

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHVLNHPLVEHKLTVLRDKNTPSSIFRELVSELVMLEAYEATRNLSVVAAPIETPVAP
CEEEECCCCHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
MTGKKLAEPRPIIVPVLRAGLGMLDGMTRLMPTAEVGFLGMKRDEEHPTQQVTYANRLPE
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCEEECCCCCCCCHHHHHHHHCCCC
DLSGRQCFLIDPMLATGGTLVAATHYLAERGAKDVTAINIIAAPEGIKYVEEHIDPSIEF
CCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCEE
KVVVCAVDEKLNDKCYIVPGLGDAGDRLYGVID
EEEEEEECCCCCCCEEEEECCCCCCCCEEEECC
>Mature Secondary Structure
MELHVLNHPLVEHKLTVLRDKNTPSSIFRELVSELVMLEAYEATRNLSVVAAPIETPVAP
CEEEECCCCHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
MTGKKLAEPRPIIVPVLRAGLGMLDGMTRLMPTAEVGFLGMKRDEEHPTQQVTYANRLPE
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCEEECCCCCCCCHHHHHHHHCCCC
DLSGRQCFLIDPMLATGGTLVAATHYLAERGAKDVTAINIIAAPEGIKYVEEHIDPSIEF
CCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCEE
KVVVCAVDEKLNDKCYIVPGLGDAGDRLYGVID
EEEEEEECCCCCCCEEEEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA