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The map label for this gene is tetB [H]

Identifier: 213692865

GI number: 213692865

Start: 2189729

End: 2191135

Strand: Reverse

Name: tetB [H]

Synonym: Blon_2006

Alternate gene names: 213692865

Gene position: 2191135-2189729 (Counterclockwise)

Preceding gene: 213692866

Following gene: 213692864

Centisome position: 77.35

GC content: 63.54

Gene sequence:

>1407_bases
ATGACATCATCGACCAACACCGCGGACGTCAAGTCCGCCGACGAGCAGGTCACCACCCAAACGGCCGTCAAGGCCCTGGT
GCTGCTGCTCATCACCTTCATCCTCGGCACCCTGTGCCTGCAGGGCTTCAACCTCGTGTTCACCCAGGTGGGCGAAGACG
TCGGCGCCCCGGCCCAGGCCTCGCTGATCACCGCCTTCCCGAGCATCGTGCTCGGCATCGTGTGCTTCATCTACGGTTCG
CTCGGCGACTTCGTCTCCCTGAAGCGACTGGTCATCGTCGGCCTGATCATGCTGTTCGTCGGCTCCGTTTTCGGGTTCGT
GGCCAACTTCTTCTTCCCCGCGAACCTGTGGACCGTCATCGTCGCCCGCGTGCTGCAGACCGCAGGCGAACAGGTGGCCG
GCTCCGTGTATCTGGTCATCACCACCAAATATCTGAAGAACGAGCTCAAGGTCGTGTTCTTCGGCCTGTACACCGCCGGC
TACCAGCTGTCCGCCTCCATCGGCGTGTTCGCTGCCGGCGCGCTCAGCTCCATCGCCTGGCAGTACCTGTTCCTCATCCC
CGCCGTCACCATCCTCTTCCTGCCCACCCTGCTCAAGAGCCTGCCCGGACGTCAGGGCAGCGGCGACAAGGTCGATTGGA
TCGGCTTCACCATCTTCGGCCTGGCCAGCGCGTTCCTCACCCTGTTCTTCTCCTACATGGCATGGTGGATGCTCATCGTG
GCCGTCGCGCTGTTCGTGGTCTTCGCCGTGTACATCGCCAAGGCCTCCGATCCGTTCGTGACCCCCGCCTTCTTCAAGAA
CACGCGCTGGCTGGCGGCCATGTCGCTGATCCTCGTGTTCTACTTCACCAACTACTGCATCTCCCCGCTGTTCAACGGCA
TCGGCACCACCGTGTACGGCATGACCACCGCCCAGGTGTCCACGTACGTCGTGTGGGCGTTCGTGTGCGCGGCCATCGTG
GGCACCTGCTCCGGCCTGATCATCGGCAGGATCGGCAAGCAGGCTGCGCTGATCATCGCCGCATGCCTCATGATCGCCGG
CTTCGTGTCCGCCGCCCTGGCCGTCAACGCCGGCTTCCTGGCGTTGACGATCGCCGCATGCGTGTTCTACTGCGGCGTGG
GTCTGATGTATTCGCCCGTGGTCTCCACCGTGCTGAGCACGATTCCGCAGGAGGAGTCCGGCCGTGGCGTGGGCATGAAC
GATCTGCTGATGAACGTGACCGCCTCCATCGGCATCTCCATCATCGGTGGACTCATGGGTTCGCAGGCGCTCGCCGGTTC
CAGCATCACCGGCGCCACCGGTGCCGCGGCCGGATACGCGAACCTGCTGCTCATCGGCGCCGGCGTCATGACGCTCGGTC
TGATTGTGTTCCTCGTGTTCCGCAAGAAGATCTACGCACAGGACTGA

Upstream 100 bases:

>100_bases
TCACCGCGCTCGCCAAGCACGCCGGGTAACGGCGTCGGCGCACGGAACATGCCGAACACCGCAAACAGAGCATAGCAAAC
AGAGAACAGAGAGGAATTCC

Downstream 100 bases:

>100_bases
TGCCATGACGCTGTCCCTGGCCATTGAAGGATCCGGCTTCACCGCGCGCACGTGCGACGAGGTCGCGTATTTCCACAACG
CCCTGTTCCTGATTGATGAC

Product: major facilitator superfamily MFS_1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTSSTNTADVKSADEQVTTQTAVKALVLLLITFILGTLCLQGFNLVFTQVGEDVGAPAQASLITAFPSIVLGIVCFIYGS
LGDFVSLKRLVIVGLIMLFVGSVFGFVANFFFPANLWTVIVARVLQTAGEQVAGSVYLVITTKYLKNELKVVFFGLYTAG
YQLSASIGVFAAGALSSIAWQYLFLIPAVTILFLPTLLKSLPGRQGSGDKVDWIGFTIFGLASAFLTLFFSYMAWWMLIV
AVALFVVFAVYIAKASDPFVTPAFFKNTRWLAAMSLILVFYFTNYCISPLFNGIGTTVYGMTTAQVSTYVVWAFVCAAIV
GTCSGLIIGRIGKQAALIIAACLMIAGFVSAALAVNAGFLALTIAACVFYCGVGLMYSPVVSTVLSTIPQEESGRGVGMN
DLLMNVTASIGISIIGGLMGSQALAGSSITGATGAAAGYANLLLIGAGVMTLGLIVFLVFRKKIYAQD

Sequences:

>Translated_468_residues
MTSSTNTADVKSADEQVTTQTAVKALVLLLITFILGTLCLQGFNLVFTQVGEDVGAPAQASLITAFPSIVLGIVCFIYGS
LGDFVSLKRLVIVGLIMLFVGSVFGFVANFFFPANLWTVIVARVLQTAGEQVAGSVYLVITTKYLKNELKVVFFGLYTAG
YQLSASIGVFAAGALSSIAWQYLFLIPAVTILFLPTLLKSLPGRQGSGDKVDWIGFTIFGLASAFLTLFFSYMAWWMLIV
AVALFVVFAVYIAKASDPFVTPAFFKNTRWLAAMSLILVFYFTNYCISPLFNGIGTTVYGMTTAQVSTYVVWAFVCAAIV
GTCSGLIIGRIGKQAALIIAACLMIAGFVSAALAVNAGFLALTIAACVFYCGVGLMYSPVVSTVLSTIPQEESGRGVGMN
DLLMNVTASIGISIIGGLMGSQALAGSSITGATGAAAGYANLLLIGAGVMTLGLIVFLVFRKKIYAQD
>Mature_467_residues
TSSTNTADVKSADEQVTTQTAVKALVLLLITFILGTLCLQGFNLVFTQVGEDVGAPAQASLITAFPSIVLGIVCFIYGSL
GDFVSLKRLVIVGLIMLFVGSVFGFVANFFFPANLWTVIVARVLQTAGEQVAGSVYLVITTKYLKNELKVVFFGLYTAGY
QLSASIGVFAAGALSSIAWQYLFLIPAVTILFLPTLLKSLPGRQGSGDKVDWIGFTIFGLASAFLTLFFSYMAWWMLIVA
VALFVVFAVYIAKASDPFVTPAFFKNTRWLAAMSLILVFYFTNYCISPLFNGIGTTVYGMTTAQVSTYVVWAFVCAAIVG
TCSGLIIGRIGKQAALIIAACLMIAGFVSAALAVNAGFLALTIAACVFYCGVGLMYSPVVSTVLSTIPQEESGRGVGMND
LLMNVTASIGISIIGGLMGSQALAGSSITGATGAAAGYANLLLIGAGVMTLGLIVFLVFRKKIYAQD

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49367; Mature: 49236

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSTNTADVKSADEQVTTQTAVKALVLLLITFILGTLCLQGFNLVFTQVGEDVGAPAQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHH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HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2844262; 7584024; 9384377 [H]