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The map label for this gene is ahcY [H]

Identifier: 213692812

GI number: 213692812

Start: 2132435

End: 2133682

Strand: Direct

Name: ahcY [H]

Synonym: Blon_1952

Alternate gene names: 213692812

Gene position: 2132435-2133682 (Clockwise)

Preceding gene: 213692807

Following gene: 213692813

Centisome position: 75.28

GC content: 61.38

Gene sequence:

>1248_bases
ATGCGCACGGCAAGTGGGCTGGAGGCAATGGAGTACGCGGAACAGCACATGCCGGTATTACGCGACACCATGGATGACCT
CACCACCCGCGTCGATTTCTCAGGCATTCGTATTGCCGTCTGCCTGATACTGGAGCCAAAAACCGCGATTCTGCTGCGCA
AGCTTAAGGCCGCCGGCGCAATCGTCGGCGTATATTGCGGCCCGGATTCCACGGATCCCCGAGTGGCGGAACAGCTGCGC
CGGGAAGGAATCACGGTCGAATCCAGCCGAGCCTGGACCGCGGAACAGGCGCACGAGGCAGCCCTGCGCCTGCTGGACAA
GATACAGCCGAACATCATCATCGACGATGGTGCCAGCTTCGCCCGTCTCGCCTCGTTCGAACGCCCCGAACTCACGGCGA
ACCTCATTGGAGTGGCCGAGGAAACGACCAGTGGCGTACGCGCGTTCCAGCAGATGCAGGAAGCGGGAGCGCTCACCTAC
CCGGTCGTAGCCGTTAACGACAGTGTGCTGAAAACCGGATTCGACAACGCCCACGGCACTGGGGAGACATGCGTGACCAC
CATGCAGCGCATTCTCGGCGAGCATGCATTCGACGGTAAGAACGTCACCGTCATCGGCTACGGCCCGGTCGGCCAAGGCT
TCGCACGGCGTATTCGCGCGCTTGGAGCCGAAGTCACCATCTGCGATATCGATCCAGTGGCTTCACTCAAAGCGGTGTTC
GACGGCTTCGCCGCACAAGACATTGACGAGGCACTCCCTTGCGCGGATATGGTGGTGTCCGCCACTGGCGTGAGACATAC
AGTCACACTTGAGCACATGCGCGCAATGCACGAGGGCGCGGCGCTCGCAGTGATCGGCGGCATCGCCAACGAAATCGCCT
TGGACGAGGTAAGCGACTTCACCCCACAGGTCAACAGGGACACCGCGCAACTCATTGTTCCCGACGGACCAACGCTCACG
CTAATCGCCGACGGCGATGGCGTGAACTACACGGTGGGAGGCGGCAATCCAATCGAGATCATGGATCTGAGCTTCGCCGT
ACAGGCCAGCGCCGTCGCATATCTTCTGGAACATCGAGGCACACTGGATCACACGCTTATCAGACTTGACGCAGCGACCG
ACCAGCGCATCGCCGCCAGCGCGCTCAAGGCGCGCGGATACCGAGCCAGCCATGCCGTGGAGGACAACGGCTACGATTGG
CGACTGACCAGATTCGCGGAAAACGACCGAGAGAACGCCGACCGATAG

Upstream 100 bases:

>100_bases
CCAGCAATGGGGCATGACCGTCGAAGATGCCACGATGACTGACGGGCACAGCGAGGAATTCCTATGTGACGGCACACAAA
GCATTGATTCCATTGCCGAC

Downstream 100 bases:

>100_bases
CCATAGACACGGCACCGAACACAACGCAGCGAGGAGAATATGACCGACAACACCTGGCCGACCGTCGATACCGAGCTTAT
CGATGATGTGACACTGTATT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MRTASGLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLKAAGAIVGVYCGPDSTDPRVAEQLR
REGITVESSRAWTAEQAHEAALRLLDKIQPNIIIDDGASFARLASFERPELTANLIGVAEETTSGVRAFQQMQEAGALTY
PVVAVNDSVLKTGFDNAHGTGETCVTTMQRILGEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDPVASLKAVF
DGFAAQDIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDFTPQVNRDTAQLIVPDGPTLT
LIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLDHTLIRLDAATDQRIAASALKARGYRASHAVEDNGYDW
RLTRFAENDRENADR

Sequences:

>Translated_415_residues
MRTASGLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLKAAGAIVGVYCGPDSTDPRVAEQLR
REGITVESSRAWTAEQAHEAALRLLDKIQPNIIIDDGASFARLASFERPELTANLIGVAEETTSGVRAFQQMQEAGALTY
PVVAVNDSVLKTGFDNAHGTGETCVTTMQRILGEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDPVASLKAVF
DGFAAQDIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDFTPQVNRDTAQLIVPDGPTLT
LIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLDHTLIRLDAATDQRIAASALKARGYRASHAVEDNGYDW
RLTRFAENDRENADR
>Mature_415_residues
MRTASGLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLKAAGAIVGVYCGPDSTDPRVAEQLR
REGITVESSRAWTAEQAHEAALRLLDKIQPNIIIDDGASFARLASFERPELTANLIGVAEETTSGVRAFQQMQEAGALTY
PVVAVNDSVLKTGFDNAHGTGETCVTTMQRILGEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDPVASLKAVF
DGFAAQDIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDFTPQVNRDTAQLIVPDGPTLT
LIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLDHTLIRLDAATDQRIAASALKARGYRASHAVEDNGYDW
RLTRFAENDRENADR

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI195539349, Length=389, Percent_Identity=29.8200514138817, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI298286489, Length=389, Percent_Identity=29.8200514138817, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI195539337, Length=389, Percent_Identity=29.8200514138817, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI24308043, Length=389, Percent_Identity=29.8200514138817, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI9951915, Length=369, Percent_Identity=32.7913279132791, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI239937451, Length=356, Percent_Identity=32.5842696629214, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI21361647, Length=403, Percent_Identity=28.0397022332506, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17506425, Length=363, Percent_Identity=32.2314049586777, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320882, Length=363, Percent_Identity=31.6804407713499, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24656245, Length=359, Percent_Identity=32.5905292479109, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642172, Length=400, Percent_Identity=30.25, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45553385, Length=339, Percent_Identity=30.3834808259587, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45553387, Length=339, Percent_Identity=30.3834808259587, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 44601; Mature: 44601

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00457 NA_SOLUT_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTASGLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLKAAGA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHCCC
IVGVYCGPDSTDPRVAEQLRREGITVESSRAWTAEQAHEAALRLLDKIQPNIIIDDGASF
EEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCH
ARLASFERPELTANLIGVAEETTSGVRAFQQMQEAGALTYPVVAVNDSVLKTGFDNAHGT
HHHHCCCCCCCHHHHEECHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHCCCCCCCCC
GETCVTTMQRILGEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDPVASLKAVF
CHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
DGFAAQDIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDF
CCHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHHHHCCCEEEEECHHHHHHHHHHHHHC
TPQVNRDTAQLIVPDGPTLTLIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRG
CCCCCCCCEEEEECCCCEEEEEECCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHHCC
TLDHTLIRLDAATDQRIAASALKARGYRASHAVEDNGYDWRLTRFAENDRENADR
CCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHCCCCCCCC
>Mature Secondary Structure
MRTASGLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLKAAGA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHCCC
IVGVYCGPDSTDPRVAEQLRREGITVESSRAWTAEQAHEAALRLLDKIQPNIIIDDGASF
EEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCH
ARLASFERPELTANLIGVAEETTSGVRAFQQMQEAGALTYPVVAVNDSVLKTGFDNAHGT
HHHHCCCCCCCHHHHEECHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHCCCCCCCCC
GETCVTTMQRILGEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDPVASLKAVF
CHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
DGFAAQDIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDF
CCHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHHHHCCCEEEEECHHHHHHHHHHHHHC
TPQVNRDTAQLIVPDGPTLTLIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRG
CCCCCCCCEEEEECCCCEEEEEECCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHHCC
TLDHTLIRLDAATDQRIAASALKARGYRASHAVEDNGYDWRLTRFAENDRENADR
CCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]