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The map label for this gene is purC [H]

Identifier: 213692802

GI number: 213692802

Start: 2119432

End: 2120184

Strand: Direct

Name: purC [H]

Synonym: Blon_1940

Alternate gene names: 213692802

Gene position: 2119432-2120184 (Clockwise)

Preceding gene: 213692800

Following gene: 213692803

Centisome position: 74.82

GC content: 60.03

Gene sequence:

>753_bases
ATGGAGAAGCTGGAAAAGCTCTACGAGGGCAAGGCCAAGCAACTGTACGCAACCGACGATCCAGAGGTTCTGTGGGTCGA
ATACAAGAACACCGCCACCGCTGGCGATGGTGAAAAGAAGGAAGACTTCACCGGCAAAGGCCGCCTGAACAACCTCATCA
CCACCATCATCTTCGACCTGCTCAAGAAGCGCGGTATCGACAGCCACCTCATCAAGCGAGTGAACGACACCGGCCAGCTG
GTGCGCAAGGTGAACATGTTCCCGTTGGAGATCGTGCTGCGCAACGTGGCCGCCGGCCACTTCTGCTCCCGTCTGGGCGT
GGAGGAAGGGCTGCCGCTCAAGGAGCCGGTGCTTGAGTACTTCCTGAAGAACGATGATCTGCACGATCCGTTCGTCAACG
ACGATGACCTGGTGGCCCTCGACGTATGCACTCGCGAGGATCTCGCCGAGATCGCCCCGCTGGCCCGCAAGATCAACGAG
GCCCTGATCGAGATCTTCGCCAAGATCGACGTCAAGCTGGTCGACTTCAAGATCGAAATGGGCCGCGCCACCGACGGCAC
GCTGCTGTTGGCCGACGAGATCACCCCGGATTCCTGCCGTCTGTGGGACCAGAAGGACCACTCCGGCAAGGTCGAGCACC
TTGACAAGGACCTGTTCCGCCGTGGTCTCGGCAGCATCATCCCGGCCTACGAAGAGATCGAGGAGCGCCTCGCCGAACTC
GCCAAGTCCGAAGGCATCGAAGTCGCCGAATAA

Upstream 100 bases:

>100_bases
CTGACCGCATCGTAGCGTCATGCTGAGTGTTGTTGTAGCCCTCGATTGGTACCCTTTTACCGTTAGTTCACCCAGAAATT
CCACTCCTGAAAGGTGAGTC

Downstream 100 bases:

>100_bases
GTCGTTTAGGTGCAGGTAGCAGAACATACAGCTGGCTCCCCTCTCTGAGGGGAGCTGTCGCCGATAGGCGACTGAGGGGA
GGTCAAGACGTTCACCGCCA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MEKLEKLYEGKAKQLYATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDLLKKRGIDSHLIKRVNDTGQL
VRKVNMFPLEIVLRNVAAGHFCSRLGVEEGLPLKEPVLEYFLKNDDLHDPFVNDDDLVALDVCTREDLAEIAPLARKINE
ALIEIFAKIDVKLVDFKIEMGRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFRRGLGSIIPAYEEIEERLAEL
AKSEGIEVAE

Sequences:

>Translated_250_residues
MEKLEKLYEGKAKQLYATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDLLKKRGIDSHLIKRVNDTGQL
VRKVNMFPLEIVLRNVAAGHFCSRLGVEEGLPLKEPVLEYFLKNDDLHDPFVNDDDLVALDVCTREDLAEIAPLARKINE
ALIEIFAKIDVKLVDFKIEMGRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFRRGLGSIIPAYEEIEERLAEL
AKSEGIEVAE
>Mature_250_residues
MEKLEKLYEGKAKQLYATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDLLKKRGIDSHLIKRVNDTGQL
VRKVNMFPLEIVLRNVAAGHFCSRLGVEEGLPLKEPVLEYFLKNDDLHDPFVNDDDLVALDVCTREDLAEIAPLARKINE
ALIEIFAKIDVKLVDFKIEMGRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFRRGLGSIIPAYEEIEERLAEL
AKSEGIEVAE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=258, Percent_Identity=34.1085271317829, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI5453539, Length=258, Percent_Identity=34.1085271317829, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI119220559, Length=265, Percent_Identity=33.2075471698113, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=41.5966386554622, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17531275, Length=258, Percent_Identity=30.6201550387597, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18860083, Length=225, Percent_Identity=32.8888888888889, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=28, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28278; Mature: 28278

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLEKLYEGKAKQLYATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDL
CHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKKRGIDSHLIKRVNDTGQLVRKVNMFPLEIVLRNVAAGHFCSRLGVEEGLPLKEPVLEY
HHHCCCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FLKNDDLHDPFVNDDDLVALDVCTREDLAEIAPLARKINEALIEIFAKIDVKLVDFKIEM
HHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEE
GRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFRRGLGSIIPAYEEIEERLAEL
CCCCCCEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKSEGIEVAE
HHHCCCCCCC
>Mature Secondary Structure
MEKLEKLYEGKAKQLYATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDL
CHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LKKRGIDSHLIKRVNDTGQLVRKVNMFPLEIVLRNVAAGHFCSRLGVEEGLPLKEPVLEY
HHHCCCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FLKNDDLHDPFVNDDDLVALDVCTREDLAEIAPLARKINEALIEIFAKIDVKLVDFKIEM
HHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEE
GRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFRRGLGSIIPAYEEIEERLAEL
CCCCCCEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKSEGIEVAE
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA