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The map label for this gene is thrC [H]

Identifier: 213692715

GI number: 213692715

Start: 2016318

End: 2017808

Strand: Direct

Name: thrC [H]

Synonym: Blon_1848

Alternate gene names: 213692715

Gene position: 2016318-2017808 (Clockwise)

Preceding gene: 213692710

Following gene: 213692722

Centisome position: 71.18

GC content: 64.19

Gene sequence:

>1491_bases
GTGACAACCACCTTCCATTCCACCCGCAGCACCACCGATTCGCTGACCGCCAAGCAGGCGATTCGTAAGGGCATCGCCGA
TGACGGCGGCCTGTTCGTTTCGGACGCGTTGGGCAAGACCAAGGTGGACGTGGCCTCCCTGCCGGGCAAGTCGTACCAGC
AAATCGCCGCCGAGGTGCTGGGCGCGCTGCTGCCGGACTTCACGGCCGAGGAGCTGGGCCAGTGCATCGCCGACGCCTAC
GGCAAACAGTGGTCCGATGAGCGCATCACCCCACTCAAGCCCCTGGGTGACGATTACGTGCTCGAACTGTTCAACGGTCC
GACTTCCGCGTTCAAGGACGTGGCGCTGCAGATCCTGCCGCGCTTCATGGCGCACACCACGCCGGCCGATGGCAACGCGG
ACGAGAAAATCATGATCCTCACCGCCACCTCCGGCGACACCGGCAAGGCCGCGCTGGCCGGCTTCGCGGACGCCCCGGGC
ACCGCGATCACCGTCTTCTACCCGGAAGGCAAGGTCTCCCAGGTCCAGGAGCTGCAGATGACCACGCAGGCCGGCGCCAA
CGTGCATGTGGCCGCCGTGGAAGGCAACTTCGACGACGCCCAGTCCGCGGTCAAACGCATCTTCGGCGACCGCGCCCTGG
CCGAGCGTCTCGCCGGCAATTCGCACGTGGTACTTTCCTCCGCCAACTCCATCAACGTGGGCCGTCTGGTGCCGCAGGTC
GTCTACTACTTCTCCGCTTACGCCCAGCTGCTCGCCGACCAGGTGATCAATGTCGGCGATGAGGTCGAGTTTGTGGTCCC
GACCGGCAATTTCGGCGATATCCTCGCCGGCTACTATGCCAAGCTGCTCGGTCTGCCGGTCAAGCACCTCGTGGTGGCTT
CCGACAAGAACAACGTGCTGTTCGACTTCCTGACCACCGGTACCTACAACCGCCAGCGCCCGTTCTTCCAGACCATCTCC
CCCTCGATGGACATCCTCATCTCCTCCAACCTGGAGCGCATGCTGTACTACTTGTCCGAGGGCGACACCCGTCTGATCTC
CATGCTGATGAACGACCTCAACAAGTGGGGCACGTACGAGATCCCGGAAGAACTGCTGGCCAAGATTCGTCAGATCTTCG
GCACCGGTTGGGCCGATGAGGATCAGGTACGCGAGTCCATCAAGCACTGCTGGGACGAGAACCACTACGTGATCGACCCG
CACACCGCCTGCGGCTACTACCTGCTTGAGCAGATGCCGCGAGACCCGCTGACCCCGCGCGTGCTGCTCTCCACCGCCAG
CCCCTACAAGTTCCCGCGCGTGGTGAACGAGGCATTGGGCTTCGACGCCACCGGCACCGACTTCGAGTGCATGGATGTGC
TGGCCCACGAGACCGGCACCACCGCCCCGGCCGCCCTGCGTGGTCTCGAGACCGCCGACGTGCGTTTCAAGGACGTCGTG
GCCATCGACGGCATGGAGGACTACGTGGAGAAGGCCGCCCAGGCGCTGTAA

Upstream 100 bases:

>100_bases
GGTGCGACCGGTCGGCTACGCGAGACGGACGGCCCTTCTGCCCACGGCCCACGCTAGACTGGTGTGGATTCATCATCCCT
TTCAGGCAGAAGGATTCATC

Downstream 100 bases:

>100_bases
ACATACCAGCACATTGGCTCCCCTCAGAGAGGGGAGCCATTTTTTACATCAGAATTGCGTTTACATCAGTATCGCGGCGA
CTGGCAGTCCTATGGCGATT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTTTFHSTRSTTDSLTAKQAIRKGIADDGGLFVSDALGKTKVDVASLPGKSYQQIAAEVLGALLPDFTAEELGQCIADAY
GKQWSDERITPLKPLGDDYVLELFNGPTSAFKDVALQILPRFMAHTTPADGNADEKIMILTATSGDTGKAALAGFADAPG
TAITVFYPEGKVSQVQELQMTTQAGANVHVAAVEGNFDDAQSAVKRIFGDRALAERLAGNSHVVLSSANSINVGRLVPQV
VYYFSAYAQLLADQVINVGDEVEFVVPTGNFGDILAGYYAKLLGLPVKHLVVASDKNNVLFDFLTTGTYNRQRPFFQTIS
PSMDILISSNLERMLYYLSEGDTRLISMLMNDLNKWGTYEIPEELLAKIRQIFGTGWADEDQVRESIKHCWDENHYVIDP
HTACGYYLLEQMPRDPLTPRVLLSTASPYKFPRVVNEALGFDATGTDFECMDVLAHETGTTAPAALRGLETADVRFKDVV
AIDGMEDYVEKAAQAL

Sequences:

>Translated_496_residues
MTTTFHSTRSTTDSLTAKQAIRKGIADDGGLFVSDALGKTKVDVASLPGKSYQQIAAEVLGALLPDFTAEELGQCIADAY
GKQWSDERITPLKPLGDDYVLELFNGPTSAFKDVALQILPRFMAHTTPADGNADEKIMILTATSGDTGKAALAGFADAPG
TAITVFYPEGKVSQVQELQMTTQAGANVHVAAVEGNFDDAQSAVKRIFGDRALAERLAGNSHVVLSSANSINVGRLVPQV
VYYFSAYAQLLADQVINVGDEVEFVVPTGNFGDILAGYYAKLLGLPVKHLVVASDKNNVLFDFLTTGTYNRQRPFFQTIS
PSMDILISSNLERMLYYLSEGDTRLISMLMNDLNKWGTYEIPEELLAKIRQIFGTGWADEDQVRESIKHCWDENHYVIDP
HTACGYYLLEQMPRDPLTPRVLLSTASPYKFPRVVNEALGFDATGTDFECMDVLAHETGTTAPAALRGLETADVRFKDVV
AIDGMEDYVEKAAQAL
>Mature_495_residues
TTTFHSTRSTTDSLTAKQAIRKGIADDGGLFVSDALGKTKVDVASLPGKSYQQIAAEVLGALLPDFTAEELGQCIADAYG
KQWSDERITPLKPLGDDYVLELFNGPTSAFKDVALQILPRFMAHTTPADGNADEKIMILTATSGDTGKAALAGFADAPGT
AITVFYPEGKVSQVQELQMTTQAGANVHVAAVEGNFDDAQSAVKRIFGDRALAERLAGNSHVVLSSANSINVGRLVPQVV
YYFSAYAQLLADQVINVGDEVEFVVPTGNFGDILAGYYAKLLGLPVKHLVVASDKNNVLFDFLTTGTYNRQRPFFQTISP
SMDILISSNLERMLYYLSEGDTRLISMLMNDLNKWGTYEIPEELLAKIRQIFGTGWADEDQVRESIKHCWDENHYVIDPH
TACGYYLLEQMPRDPLTPRVLLSTASPYKFPRVVNEALGFDATGTDFECMDVLAHETGTTAPAALRGLETADVRFKDVVA
IDGMEDYVEKAAQAL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=457, Percent_Identity=39.3873085339169, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=32.2654462242563, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1786185, Length=443, Percent_Identity=30.4740406320542, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=495, Percent_Identity=36.969696969697, Blast_Score=263, Evalue=4e-71,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54055; Mature: 53923

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTFHSTRSTTDSLTAKQAIRKGIADDGGLFVSDALGKTKVDVASLPGKSYQQIAAEVL
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEHHHCCCHHHHHHHHHHH
GALLPDFTAEELGQCIADAYGKQWSDERITPLKPLGDDYVLELFNGPTSAFKDVALQILP
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
RFMAHTTPADGNADEKIMILTATSGDTGKAALAGFADAPGTAITVFYPEGKVSQVQELQM
HHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEECCCCCHHHHHHHHH
TTQAGANVHVAAVEGNFDDAQSAVKRIFGDRALAERLAGNSHVVLSSANSINVGRLVPQV
HHHCCCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
VYYFSAYAQLLADQVINVGDEVEFVVPTGNFGDILAGYYAKLLGLPVKHLVVASDKNNVL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEE
FDFLTTGTYNRQRPFFQTISPSMDILISSNLERMLYYLSEGDTRLISMLMNDLNKWGTYE
EEEEECCCCCCCCCHHHHCCCCHHEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
IPEELLAKIRQIFGTGWADEDQVRESIKHCWDENHYVIDPHTACGYYLLEQMPRDPLTPR
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCE
VLLSTASPYKFPRVVNEALGFDATGTDFECMDVLAHETGTTAPAALRGLETADVRFKDVV
EEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEHEE
AIDGMEDYVEKAAQAL
EECCHHHHHHHHHHCC
>Mature Secondary Structure 
TTTFHSTRSTTDSLTAKQAIRKGIADDGGLFVSDALGKTKVDVASLPGKSYQQIAAEVL
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEHHHCCCHHHHHHHHHHH
GALLPDFTAEELGQCIADAYGKQWSDERITPLKPLGDDYVLELFNGPTSAFKDVALQILP
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
RFMAHTTPADGNADEKIMILTATSGDTGKAALAGFADAPGTAITVFYPEGKVSQVQELQM
HHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEECCCCCHHHHHHHHH
TTQAGANVHVAAVEGNFDDAQSAVKRIFGDRALAERLAGNSHVVLSSANSINVGRLVPQV
HHHCCCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
VYYFSAYAQLLADQVINVGDEVEFVVPTGNFGDILAGYYAKLLGLPVKHLVVASDKNNVL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEE
FDFLTTGTYNRQRPFFQTISPSMDILISSNLERMLYYLSEGDTRLISMLMNDLNKWGTYE
EEEEECCCCCCCCCHHHHCCCCHHEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
IPEELLAKIRQIFGTGWADEDQVRESIKHCWDENHYVIDPHTACGYYLLEQMPRDPLTPR
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCE
VLLSTASPYKFPRVVNEALGFDATGTDFECMDVLAHETGTTAPAALRGLETADVRFKDVV
EEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEHEE
AIDGMEDYVEKAAQAL
EECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]