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The map label for this gene is clcB [H]

Identifier: 213692578

GI number: 213692578

Start: 1871239

End: 1872705

Strand: Reverse

Name: clcB [H]

Synonym: Blon_1710

Alternate gene names: 213692578

Gene position: 1872705-1871239 (Counterclockwise)

Preceding gene: 213692579

Following gene: 213692577

Centisome position: 66.11

GC content: 59.17

Gene sequence:

>1467_bases
ATGCAGCCAACGGTTACTATCAAACGCCTTGGTTGGCTCGCTGCGGCGACCATTGTGCTCGGCGTGCTCATCGGTGTGGG
AGCAGGTCTGCTGACCCTGTTGCTCTACGGCGTTGAACATGTGCTGCTCGGCTACATCGAAGGCCCAGAATTGTCTGGTC
CATTCGGCGTGCCCGCTGCACGCCGTGCGATATCGGTGACCGTGGGACTCGGCATCGCGGGCATTATCTGGTATCTGTTA
CGCCGCAAAACGACTGCGGTATCTTCAGTCAAGAAGGCCGTGGCAGGGGAGCGAATGCCTTTCTGGCAGACCATTGTGCA
TGTGGTGTTGCAGATTTTCATCGTCGGCTCCGGCGCCTCGATCGGCCGAGAAGTCGCCCCACGCGAACTCGGCACCATGA
TCGCGCAACGTTTCTGCGACCTGTTCCATATCGAGGGCGTTGACGGCATCGACCGGCGCATGGTGGTGGCAGTGGCTGCC
GGTGCCGGTCTAGGAGGCGTCTATGACGCGCCACTGGCCGGCATGTTCTTCGCCGTCGAAATCCTATTGGTGGATGTGAC
GATCGAAAAGGTTGCCTTTGGACTGGGCATGTCTGCCATTGCCGCATTCGTGGCGGTTGCGATCAAAGGGCATTGCCTGT
TCTACGACATTACCGCCATGCAACCGGAATCCACGCCAACGTTAATGCTGTTCGCTCTGATCTGCGGTGCGGCATGTGGA
GTGGGCGGCGCGTTGTTCCGAAAAGGTTCGCAATGGGCGGAAGCGCACAAGCCGACCGGTAAGGCCATTCTGTGGCAGAT
GCCGCTGGCTGGTTTCATCACCGGTTTGGTGGCGATTGTTGTGCCGCAGGTGATGGGCAACGGCCGTGCCGCAGCGCAAC
TTGGATTCAGCACGTTCATTCCTGAAACCGCTGGCACTGCTGGTGCCATGCAGTCGGCATCTTCATCGGCCGCCTCTCCA
TGGAACTTGCTTACGGGCGGCGGTAATGTATCCGATTCGGCCTCTGGCGGGGGATCGGGCTCTGGAATGGCCTCGTTCTG
GGCCATGCTTCAGGGTGGGAGCGGCTCTTCTGGATCCGGGATGAACGCCGGTTTCCCGCTGTCCCAGTCCAATATCTGGA
TGTTGCTGGGTGTGTTGGCACTCACCTTTGTCACCAAAGCGCTGGTGACGCTGATGACCATTCGCTCCGGTGCATCGGGC
GGTGTGCTGCAGCCCGGCATCGCATTAGGTTCTACGCTGGGTGCGATGCTCGGCCTCGTATGGATACTGATGTTTCCGAC
CGATTCGGTAACCGCGTGTGCCTTGATTGGTGCGGCTTCGTTGCTTTCGGCTTCACAGCAGGCACCGCTTATGGCCATGT
GCTTAGTGATGGAGCTGAGCGAAGCGCCGATTAGCTTCTTTGTGCCGGTCGGCATGGCCGTGGCCACGTCGTCGTTGATA
TCAAAGTGGTTGCTGAGTCGTAAGTAA

Upstream 100 bases:

>100_bases
CTATTTCTTTGGCTCCCCTCTTTGAGGGGAGCTGTCGAGCGTAGCGAGACTGAGGGGGAGTTCCCAAGGCATACTCGTTG
CATAGGGTGCGGAGGTTGAC

Downstream 100 bases:

>100_bases
GTAGATACATATATTCTGGCTCCCCTCTCTGAGGGGAGCCGAGGTAAAGAAAGCTATGTCAGAAAATACAGAAATTCGCT
CGGCACTTGAATTGCTTGCC

Product: Cl- channel, voltage-gated family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MQPTVTIKRLGWLAAATIVLGVLIGVGAGLLTLLLYGVEHVLLGYIEGPELSGPFGVPAARRAISVTVGLGIAGIIWYLL
RRKTTAVSSVKKAVAGERMPFWQTIVHVVLQIFIVGSGASIGREVAPRELGTMIAQRFCDLFHIEGVDGIDRRMVVAVAA
GAGLGGVYDAPLAGMFFAVEILLVDVTIEKVAFGLGMSAIAAFVAVAIKGHCLFYDITAMQPESTPTLMLFALICGAACG
VGGALFRKGSQWAEAHKPTGKAILWQMPLAGFITGLVAIVVPQVMGNGRAAAQLGFSTFIPETAGTAGAMQSASSSAASP
WNLLTGGGNVSDSASGGGSGSGMASFWAMLQGGSGSSGSGMNAGFPLSQSNIWMLLGVLALTFVTKALVTLMTIRSGASG
GVLQPGIALGSTLGAMLGLVWILMFPTDSVTACALIGAASLLSASQQAPLMAMCLVMELSEAPISFFVPVGMAVATSSLI
SKWLLSRK

Sequences:

>Translated_488_residues
MQPTVTIKRLGWLAAATIVLGVLIGVGAGLLTLLLYGVEHVLLGYIEGPELSGPFGVPAARRAISVTVGLGIAGIIWYLL
RRKTTAVSSVKKAVAGERMPFWQTIVHVVLQIFIVGSGASIGREVAPRELGTMIAQRFCDLFHIEGVDGIDRRMVVAVAA
GAGLGGVYDAPLAGMFFAVEILLVDVTIEKVAFGLGMSAIAAFVAVAIKGHCLFYDITAMQPESTPTLMLFALICGAACG
VGGALFRKGSQWAEAHKPTGKAILWQMPLAGFITGLVAIVVPQVMGNGRAAAQLGFSTFIPETAGTAGAMQSASSSAASP
WNLLTGGGNVSDSASGGGSGSGMASFWAMLQGGSGSSGSGMNAGFPLSQSNIWMLLGVLALTFVTKALVTLMTIRSGASG
GVLQPGIALGSTLGAMLGLVWILMFPTDSVTACALIGAASLLSASQQAPLMAMCLVMELSEAPISFFVPVGMAVATSSLI
SKWLLSRK
>Mature_488_residues
MQPTVTIKRLGWLAAATIVLGVLIGVGAGLLTLLLYGVEHVLLGYIEGPELSGPFGVPAARRAISVTVGLGIAGIIWYLL
RRKTTAVSSVKKAVAGERMPFWQTIVHVVLQIFIVGSGASIGREVAPRELGTMIAQRFCDLFHIEGVDGIDRRMVVAVAA
GAGLGGVYDAPLAGMFFAVEILLVDVTIEKVAFGLGMSAIAAFVAVAIKGHCLFYDITAMQPESTPTLMLFALICGAACG
VGGALFRKGSQWAEAHKPTGKAILWQMPLAGFITGLVAIVVPQVMGNGRAAAQLGFSTFIPETAGTAGAMQSASSSAASP
WNLLTGGGNVSDSASGGGSGSGMASFWAMLQGGSGSSGSGMNAGFPLSQSNIWMLLGVLALTFVTKALVTLMTIRSGASG
GVLQPGIALGSTLGAMLGLVWILMFPTDSVTACALIGAASLLSASQQAPLMAMCLVMELSEAPISFFVPVGMAVATSSLI
SKWLLSRK

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=137, Percent_Identity=32.8467153284672, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 49997; Mature: 49997

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTVTIKRLGWLAAATIVLGVLIGVGAGLLTLLLYGVEHVLLGYIEGPELSGPFGVPAA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
RRAISVTVGLGIAGIIWYLLRRKTTAVSSVKKAVAGERMPFWQTIVHVVLQIFIVGSGAS
HHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
IGREVAPRELGTMIAQRFCDLFHIEGVDGIDRRMVVAVAAGAGLGGVYDAPLAGMFFAVE
CCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHH
ILLVDVTIEKVAFGLGMSAIAAFVAVAIKGHCLFYDITAMQPESTPTLMLFALICGAACG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHC
VGGALFRKGSQWAEAHKPTGKAILWQMPLAGFITGLVAIVVPQVMGNGRAAAQLGFSTFI
CCHHHHHCCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHC
PETAGTAGAMQSASSSAASPWNLLTGGGNVSDSASGGGSGSGMASFWAMLQGGSGSSGSG
CCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MNAGFPLSQSNIWMLLGVLALTFVTKALVTLMTIRSGASGGVLQPGIALGSTLGAMLGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
WILMFPTDSVTACALIGAASLLSASQQAPLMAMCLVMELSEAPISFFVPVGMAVATSSLI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SKWLLSRK
HHHHHCCC
>Mature Secondary Structure
MQPTVTIKRLGWLAAATIVLGVLIGVGAGLLTLLLYGVEHVLLGYIEGPELSGPFGVPAA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
RRAISVTVGLGIAGIIWYLLRRKTTAVSSVKKAVAGERMPFWQTIVHVVLQIFIVGSGAS
HHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
IGREVAPRELGTMIAQRFCDLFHIEGVDGIDRRMVVAVAAGAGLGGVYDAPLAGMFFAVE
CCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHH
ILLVDVTIEKVAFGLGMSAIAAFVAVAIKGHCLFYDITAMQPESTPTLMLFALICGAACG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHC
VGGALFRKGSQWAEAHKPTGKAILWQMPLAGFITGLVAIVVPQVMGNGRAAAQLGFSTFI
CCHHHHHCCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHC
PETAGTAGAMQSASSSAASPWNLLTGGGNVSDSASGGGSGSGMASFWAMLQGGSGSSGSG
CCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MNAGFPLSQSNIWMLLGVLALTFVTKALVTLMTIRSGASGGVLQPGIALGSTLGAMLGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
WILMFPTDSVTACALIGAASLLSASQQAPLMAMCLVMELSEAPISFFVPVGMAVATSSLI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SKWLLSRK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA