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The map label for this gene is clpP [H]

Identifier: 213692575

GI number: 213692575

Start: 1869267

End: 1869968

Strand: Reverse

Name: clpP [H]

Synonym: Blon_1707

Alternate gene names: 213692575

Gene position: 1869968-1869267 (Counterclockwise)

Preceding gene: 213692576

Following gene: 213692574

Centisome position: 66.01

GC content: 63.53

Gene sequence:

>702_bases
ATGGCAAGTGAAGAAGCAAAGTTCGCCGCCCGTGCCGACCGCTTGGCCGGCCGTCAGGGCGTAGCCGGTTTCATGCCGGA
CGCCGCCCGCGCAGCCCAGCCCGCGCCGACCAACCGTTACATCATGCCGCAGTTCGTGGAGAAGACCCCGTATGGCATGA
AGACCCAGGACGCCTACTCCCGCCTGTTCGAGGACCGCATCATCTTCCTCGGCGTGCAGGTGGACGACGCCTCCGCCGAC
GACGTGATGGCCCAGCTGCTGGTCCTCGAATCCCAAGATCCGAACCGTGACGTGATGATGTACATCAATTCACCCGGCGG
TTCGATGACGGCCATGACCGCCATCTACGACACCATGCAGTACATCAAGCCCGACGTGCAGACCGTGTGTCTCGGCCAGG
CCGCCTCCGCCGCCGCCATTCTGCTGGCCTCCGGCACCGAGGGCAAGCGCCTGATGCTGCCGAACGCCCGTGTGCTCATC
CACCAGCCGGCCATCGACCAAGGCTTCGGCAAGGCCACGGAGATCGAGATTCAGGCCAAGGAAATGCTGCGTATGCGCGA
ATGGCTGGAGGAGACCCTCGCCAAGCACACCGGCCAGGACGTCGAGAAGATTCGCCGCGACATCGAAGTGGACACTTTCC
TGACCGCTCCTGAAGCCAAGGAATACGGCATCGTGGACGAGGTGCTGGAACACCGCCAGTAA

Upstream 100 bases:

>100_bases
ACTGGTTCACCGCCCAGGAAGCCCTCGACTATGGCTTCGTGGACAAGCTCGTGACCACGCCGGACACCATCGGCAACAAC
CAGCAGGGGGAGTGAGACTC

Downstream 100 bases:

>100_bases
AACTTCCGGACATTGCAATACCCTCGGTCGGCAACGACCGGGGGTATTGTATTTCAAGGATGACAATGATAATGCGCAGC
GTGGCGGTTCGACGGTGCGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MASEEAKFAARADRLAGRQGVAGFMPDAARAAQPAPTNRYIMPQFVEKTPYGMKTQDAYSRLFEDRIIFLGVQVDDASAD
DVMAQLLVLESQDPNRDVMMYINSPGGSMTAMTAIYDTMQYIKPDVQTVCLGQAASAAAILLASGTEGKRLMLPNARVLI
HQPAIDQGFGKATEIEIQAKEMLRMREWLEETLAKHTGQDVEKIRRDIEVDTFLTAPEAKEYGIVDEVLEHRQ

Sequences:

>Translated_233_residues
MASEEAKFAARADRLAGRQGVAGFMPDAARAAQPAPTNRYIMPQFVEKTPYGMKTQDAYSRLFEDRIIFLGVQVDDASAD
DVMAQLLVLESQDPNRDVMMYINSPGGSMTAMTAIYDTMQYIKPDVQTVCLGQAASAAAILLASGTEGKRLMLPNARVLI
HQPAIDQGFGKATEIEIQAKEMLRMREWLEETLAKHTGQDVEKIRRDIEVDTFLTAPEAKEYGIVDEVLEHRQ
>Mature_232_residues
ASEEAKFAARADRLAGRQGVAGFMPDAARAAQPAPTNRYIMPQFVEKTPYGMKTQDAYSRLFEDRIIFLGVQVDDASADD
VMAQLLVLESQDPNRDVMMYINSPGGSMTAMTAIYDTMQYIKPDVQTVCLGQAASAAAILLASGTEGKRLMLPNARVLIH
QPAIDQGFGKATEIEIQAKEMLRMREWLEETLAKHTGQDVEKIRRDIEVDTFLTAPEAKEYGIVDEVLEHRQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=46.5968586387435, Blast_Score=177, Evalue=9e-45,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=53.0927835051546, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17538017, Length=194, Percent_Identity=41.2371134020619, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=45.360824742268, Blast_Score=176, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25858; Mature: 25727

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEEAKFAARADRLAGRQGVAGFMPDAARAAQPAPTNRYIMPQFVEKTPYGMKTQDAYS
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHH
RLFEDRIIFLGVQVDDASADDVMAQLLVLESQDPNRDVMMYINSPGGSMTAMTAIYDTMQ
HHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
YIKPDVQTVCLGQAASAAAILLASGTEGKRLMLPNARVLIHQPAIDQGFGKATEIEIQAK
HHCCCHHHHHHCCCCCCEEEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHH
EMLRMREWLEETLAKHTGQDVEKIRRDIEVDTFLTAPEAKEYGIVDEVLEHRQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
ASEEAKFAARADRLAGRQGVAGFMPDAARAAQPAPTNRYIMPQFVEKTPYGMKTQDAYS
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCHHHHH
RLFEDRIIFLGVQVDDASADDVMAQLLVLESQDPNRDVMMYINSPGGSMTAMTAIYDTMQ
HHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
YIKPDVQTVCLGQAASAAAILLASGTEGKRLMLPNARVLIHQPAIDQGFGKATEIEIQAK
HHCCCHHHHHHCCCCCCEEEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHH
EMLRMREWLEETLAKHTGQDVEKIRRDIEVDTFLTAPEAKEYGIVDEVLEHRQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]