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The map label for this gene is proC [H]

Identifier: 213692558

GI number: 213692558

Start: 1844182

End: 1845003

Strand: Reverse

Name: proC [H]

Synonym: Blon_1690

Alternate gene names: 213692558

Gene position: 1845003-1844182 (Counterclockwise)

Preceding gene: 213692559

Following gene: 213692557

Centisome position: 65.13

GC content: 63.75

Gene sequence:

>822_bases
ATGACTCAGAACCTCACCATCGGTTTTATCGGATATGGCAACATGGCCCAGGCCATCGCCCAAGGCGTCGTCGACGCGGG
CGTGGTCACCGGCGGCCAGATGGTCGCCTGTGCCGCCCACTACGACAAGCTTGAGAAGACCACCGCCGAACTTGGCGTGC
GCCCGTTGCGCAATGCGCTGGAAGTGGTGACGGCCGCCGACGTGGTCATCATCGCCATCAAGCCCTACCAGATCGCCGCC
GTCGTCAAGCCGCTGGCCGACGAACTTGCCAGGCCGGGCAAGATCGTCGTCTCCATCGCCGCCGGCTGGAATCTCAAGAA
GTACCAGGACCTGTTCGCCACCGAAGACGGCGAATCCGTCGACTCCCCGGACATCCATATCCAGTGCACCATTCCGAACA
CTCCGATGGCCGTGGGCAAGGGCGTGCTCGTCACCGAATCCGTCAACACCCTGACCGACGACGAAACCGAAACCTTCGAG
CAGCTATTCGGCCCCATCAGCCTCATCGAGCGCGTGGACACCGCGCATATGAACATCGCCATGGTGGTGGCTGGCTGTGC
GCCCGCCTTCACTGACATGTACATCGAGGCCTTGGGCGACGCCGGCGTGCAGTACGGTCTGCAGCGAGCCACCGCCTACC
GGCTCGCCGCCAAGATGGTCGAAGGTGTCGGCGCGCTCTACATGGCCACTGAAACCCATCCCGGTGCCATGAAGGACGCC
GTCTGCTCGCCCGGTGGTACCACCATCAAGGGCGTCGCCCAGCTTGAAAAGGACGGGTTCCGCGGCTCGGTCATCGACGC
CGTAGACGCCATCGTCGGCTGA

Upstream 100 bases:

>100_bases
GAAGCCCTCAACCGGGGCGATCTTGAAGCATTGTTCTGACTCAAGGAAGCAAGCTCCCTCTGATGAGGGAGCTCTGTATA
CATGCACGAAAGGAAAACGT

Downstream 100 bases:

>100_bases
CTGCCAATCAGAGTTCGCGTATATTCGCATATCACAGTCAAAGCCTTCGAACCGTATGCTCGGAGGCCTTTGCATATGGC
CGGTTCACCACATGCAGGTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTQNLTIGFIGYGNMAQAIAQGVVDAGVVTGGQMVACAAHYDKLEKTTAELGVRPLRNALEVVTAADVVIIAIKPYQIAA
VVKPLADELARPGKIVVSIAAGWNLKKYQDLFATEDGESVDSPDIHIQCTIPNTPMAVGKGVLVTESVNTLTDDETETFE
QLFGPISLIERVDTAHMNIAMVVAGCAPAFTDMYIEALGDAGVQYGLQRATAYRLAAKMVEGVGALYMATETHPGAMKDA
VCSPGGTTIKGVAQLEKDGFRGSVIDAVDAIVG

Sequences:

>Translated_273_residues
MTQNLTIGFIGYGNMAQAIAQGVVDAGVVTGGQMVACAAHYDKLEKTTAELGVRPLRNALEVVTAADVVIIAIKPYQIAA
VVKPLADELARPGKIVVSIAAGWNLKKYQDLFATEDGESVDSPDIHIQCTIPNTPMAVGKGVLVTESVNTLTDDETETFE
QLFGPISLIERVDTAHMNIAMVVAGCAPAFTDMYIEALGDAGVQYGLQRATAYRLAAKMVEGVGALYMATETHPGAMKDA
VCSPGGTTIKGVAQLEKDGFRGSVIDAVDAIVG
>Mature_272_residues
TQNLTIGFIGYGNMAQAIAQGVVDAGVVTGGQMVACAAHYDKLEKTTAELGVRPLRNALEVVTAADVVIIAIKPYQIAAV
VKPLADELARPGKIVVSIAAGWNLKKYQDLFATEDGESVDSPDIHIQCTIPNTPMAVGKGVLVTESVNTLTDDETETFEQ
LFGPISLIERVDTAHMNIAMVVAGCAPAFTDMYIEALGDAGVQYGLQRATAYRLAAKMVEGVGALYMATETHPGAMKDAV
CSPGGTTIKGVAQLEKDGFRGSVIDAVDAIVG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=32.962962962963, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.8181818181818, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=31.3432835820896, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=31.3432835820896, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786585, Length=262, Percent_Identity=36.6412213740458, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=32.4626865671642, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=32.404181184669, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=207, Percent_Identity=25.1207729468599, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648116, Length=270, Percent_Identity=34.4444444444444, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=33.7078651685393, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24647700, Length=152, Percent_Identity=35.5263157894737, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28602; Mature: 28471

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNLTIGFIGYGNMAQAIAQGVVDAGVVTGGQMVACAAHYDKLEKTTAELGVRPLRNAL
CCCCEEEEEEECCHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHCHHHHHHHH
EVVTAADVVIIAIKPYQIAAVVKPLADELARPGKIVVSIAAGWNLKKYQDLFATEDGESV
HHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCC
DSPDIHIQCTIPNTPMAVGKGVLVTESVNTLTDDETETFEQLFGPISLIERVDTAHMNIA
CCCCEEEEEECCCCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHE
MVVAGCAPAFTDMYIEALGDAGVQYGLQRATAYRLAAKMVEGVGALYMATETHPGAMKDA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
VCSPGGTTIKGVAQLEKDGFRGSVIDAVDAIVG
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQNLTIGFIGYGNMAQAIAQGVVDAGVVTGGQMVACAAHYDKLEKTTAELGVRPLRNAL
CCCEEEEEEECCHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHCHHHHHHHH
EVVTAADVVIIAIKPYQIAAVVKPLADELARPGKIVVSIAAGWNLKKYQDLFATEDGESV
HHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCC
DSPDIHIQCTIPNTPMAVGKGVLVTESVNTLTDDETETFEQLFGPISLIERVDTAHMNIA
CCCCEEEEEECCCCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHE
MVVAGCAPAFTDMYIEALGDAGVQYGLQRATAYRLAAKMVEGVGALYMATETHPGAMKDA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
VCSPGGTTIKGVAQLEKDGFRGSVIDAVDAIVG
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188947; 9665876 [H]