Click here to switch to the map view.

The map label for this gene is cbh [H]

Identifier: 213692328

GI number: 213692328

Start: 1614024

End: 1614977

Strand: Reverse

Name: cbh [H]

Synonym: Blon_1453

Alternate gene names: 213692328

Gene position: 1614977-1614024 (Counterclockwise)

Preceding gene: 213692329

Following gene: 213692327

Centisome position: 57.01

GC content: 59.64

Gene sequence:

>954_bases
ATGTGCACTGGTGTCCGTTTCTCCGATGATGAGGGCAACACCTATTTCGGCCGTAATCTCGACTGGAGTTTCTCATATGG
GGAGACCATCCTGGTCACTCCGTGCGGCTACCACTATGACACGGTGTTCGGTGCGAGCGGCAAGGCGAAGCCGAACGCGG
TGATCGGCGTGGGCGTGGTCATGGCCGATAGGCCGATGTATTTCGACTGCGCCAACGAACATGGTCTGGCCATCGCCGGC
TTGAATTTCCCTGGTTACGCCTCGTTCGTCCACGAACCGGTCGAAGGCACGGAGAACGTCGCCACGTTCGAATTCCCGCT
GTGGGTGGCGCGTAATTTCGACTCCGTCGACGAGGTCGAGGAGGCGCTCAGGAACGTGACGCTCGTCTCCCAGATCGTGC
CGGGACAGCAGGAGTCGCTGCTGCACTGGTTCATCGGCGACGGCAAACGCAGCATCGTCGTCGAGCAGATGGCCGATGGC
ATGCATGTGCATCATGATGACGTCGATGTGCTGACCAATCAGCCGACGTTCGACTTCCATATGGAGAATCTGCGCAACTA
CATGTGCGTCAGCAACGAGATGGCCGAACCGACTTCATGGGGCAAGGCCTCCTTGACCGCCTGGGGTGCGGGTGTGGGCA
TGCATGGCATCCCGGGCGACGTGAGCTCCCCGTCCCGCTTCGTTCGTGTGGCCTACACCAACGCGCATTACCCGCAGCAG
AACGATGAAGCCGCCAATGTGTCGCGCCTGTTCCACACCCTCGGCTCCGTGCAGATGGTGGACGGCATGGCGAAGATGGG
CAACGGCCAGTTCGAACGCACGCTGTTCACCAGCGGATACTCGTCCAAGACCAACACCTATTACATGAACACCTATGATG
ATCCCGCCATCCGTTCCTACGCCATGGCCGATTACGATATGGATTCCTCGGAGCTCATCAGCGTCGCCCGATGA

Upstream 100 bases:

>100_bases
GCGCCGCACGTTAACCTGCTGGCGAAACCCAGAGTTCACCCAGCGGCCGATGGGTATCATGAACGTGCAAGCCAACCAAA
GCGATGGAAGGAAGTCCGTT

Downstream 100 bases:

>100_bases
CTCCTTCCCGGCTCATGCCCCATTCGGAAGGGCATGAGCGTATATAGTGGAATCTTATGGAATCGTCGATGTTCAAACCC
AGCTCCATGGACCTCATCAG

Product: Choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPCGYHYDTVFGASGKAKPNAVIGVGVVMADRPMYFDCANEHGLAIAG
LNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVEEALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADG
MHVHHDDVDVLTNQPTFDFHMENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
NDEAANVSRLFHTLGSVQMVDGMAKMGNGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSYAMADYDMDSSELISVAR

Sequences:

>Translated_317_residues
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPCGYHYDTVFGASGKAKPNAVIGVGVVMADRPMYFDCANEHGLAIAG
LNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVEEALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADG
MHVHHDDVDVLTNQPTFDFHMENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
NDEAANVSRLFHTLGSVQMVDGMAKMGNGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSYAMADYDMDSSELISVAR
>Mature_317_residues
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPCGYHYDTVFGASGKAKPNAVIGVGVVMADRPMYFDCANEHGLAIAG
LNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVEEALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADG
MHVHHDDVDVLTNQPTFDFHMENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
NDEAANVSRLFHTLGSVQMVDGMAKMGNGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSYAMADYDMDSSELISVAR

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 35101; Mature: 35101

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPCGYHYDTVFGASGKAKPNAVIGVGVV
CCCCCEEECCCCCEEECCCCCEEECCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEEE
MADRPMYFDCANEHGLAIAGLNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVE
EECCCEEEECCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEEEEECEEEECCCCCHHHHH
EALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADGMHVHHDDVDVLTNQPTFDFH
HHHHHHHHHHHHCCCCHHCEEEEEECCCCCEEEHHHHHCCCEEECCCCEEEECCCCCHHH
MENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
HHHHHHEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
NDEAANVSRLFHTLGSVQMVDGMAKMGNGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSY
CCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHE
AMADYDMDSSELISVAR
EEECCCCCHHHHHEECC
>Mature Secondary Structure
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPCGYHYDTVFGASGKAKPNAVIGVGVV
CCCCCEEECCCCCEEECCCCCEEECCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEEE
MADRPMYFDCANEHGLAIAGLNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVE
EECCCEEEECCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEEEEECEEEECCCCCHHHHH
EALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADGMHVHHDDVDVLTNQPTFDFH
HHHHHHHHHHHHCCCCHHCEEEEEECCCCCEEEHHHHHCCCEEECCCCEEEECCCCCHHH
MENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
HHHHHHEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
NDEAANVSRLFHTLGSVQMVDGMAKMGNGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSY
CCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHE
AMADYDMDSSELISVAR
EEECCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]