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The map label for this gene is guaB [C]

Identifier: 213691936

GI number: 213691936

Start: 1234913

End: 1236037

Strand: Direct

Name: guaB [C]

Synonym: Blon_1052

Alternate gene names: 213691936

Gene position: 1234913-1236037 (Clockwise)

Preceding gene: 213691933

Following gene: 213691937

Centisome position: 43.59

GC content: 68.44

Gene sequence:

>1125_bases
ATGTCTCAGGAAATTGAAATCGGTTTGGGCAAAAAGGGCCGTCTCGGCTACGCACTCGACGATGTGGCGATCGTCCCCTC
CCGTCGCACCCGCGACCCCGAGGACGTCTCCACCTCTTGGCAGATCGACGCCTATGAGTTCGATGTGCCGGTGATCGGCG
CCCCCATGGATTCGGTGACCAGCCCGGCCACCGCCATCGCCATGGGCAAGATGGGCGCGCTCGGCGTGCTCGATTTGGAA
GGTCTGTGGACCCGTTACGAGGACCCGACCCCGCTGTTGGACGAAATCGCCGGGCTGCCGGCCGATCAGGCCACCGAACG
TATCCAGCAGATCTATGCCGAGCCGGTCAAGCCGGAGCTCATCACGCAACGTCTGCACGAGATTCGCGCCGCCGGCGTCA
CCGTGGCCGGCGCGCTCTCCCCGCAGCGCACCCAGCAGTTCTACTCCACCGTGGTGGACGCGGGCGTGGACCTGTTCGTG
ATCCGCGGCACTGTGGTCTCCGCCGAGCACGTCTCTTCCGGCCAGGAACCGCTGAACCTCAAGAAGTTCATCTACGACCT
TGACGTGCCCGTCATCGTCGGCGGCGCATCCAACTACACCGCCGCCCTGCACCTGATGCGCACCGGCGCGGCCGGCGTGC
TCGTCGGCTTCGGCGGCGGCGCGGTCTCCGCCACTCGCCAGACCATCGGCGTGCAGGCCCCGATGGCCACCGCCATCGCC
GACGTGGCCGAGGCCCGCCGCGACTACATGGACGAATCCGGCGGCCGCTACGTGCAGGTCATCGCCGACGGCGGCATGGG
CGACTCCGGCAGCTTCGTCAAGGCCCTGGCCCTCGGCGCCGACGCGGTCATGCTCGGCGCGCCGCTGGCCCGCGCCACCG
AGGCCCCCGGCAAGGGCACCCACTGGGGTTCCGAAGCCCGCCACCAGACGCTGCCGCGCGGCTCCCGCACCACGGTCGGC
ACGGTCGGCCCGCTCGAACAGGTGCTGTTCGGACCGAGCCACCAGGCGGACGGCAAGACCAACTTCATCGGCGCCCTCAA
GCGCGCGATGGCCTCCACCGGCTACGTCGACGTGAAGAACTTCCAGCGTTGCGGCATGGTGGTCAACCCGTATTCCGCAC
GATAA

Upstream 100 bases:

>100_bases
TGATTTAGTCATAGCGCATGTTTGTAACGACTTGAAGCAATCGTCCGGTCCGTGGGAAACGGCCTTGTTGGCGTCCCACC
CGGGCAATAGGCTTACAACC

Downstream 100 bases:

>100_bases
TCCCGATTACCCCCTGAAGATGGGGGTTTGCCCTCCATGCAGGAGGCTTAACTTGCCCGAAGGCGCGCTCAAGTCGTTTG
ACTTGGCGCGCCTTTCGTGA

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSQEIEIGLGKKGRLGYALDDVAIVPSRRTRDPEDVSTSWQIDAYEFDVPVIGAPMDSVTSPATAIAMGKMGALGVLDLE
GLWTRYEDPTPLLDEIAGLPADQATERIQQIYAEPVKPELITQRLHEIRAAGVTVAGALSPQRTQQFYSTVVDAGVDLFV
IRGTVVSAEHVSSGQEPLNLKKFIYDLDVPVIVGGASNYTAALHLMRTGAAGVLVGFGGGAVSATRQTIGVQAPMATAIA
DVAEARRDYMDESGGRYVQVIADGGMGDSGSFVKALALGADAVMLGAPLARATEAPGKGTHWGSEARHQTLPRGSRTTVG
TVGPLEQVLFGPSHQADGKTNFIGALKRAMASTGYVDVKNFQRCGMVVNPYSAR

Sequences:

>Translated_374_residues
MSQEIEIGLGKKGRLGYALDDVAIVPSRRTRDPEDVSTSWQIDAYEFDVPVIGAPMDSVTSPATAIAMGKMGALGVLDLE
GLWTRYEDPTPLLDEIAGLPADQATERIQQIYAEPVKPELITQRLHEIRAAGVTVAGALSPQRTQQFYSTVVDAGVDLFV
IRGTVVSAEHVSSGQEPLNLKKFIYDLDVPVIVGGASNYTAALHLMRTGAAGVLVGFGGGAVSATRQTIGVQAPMATAIA
DVAEARRDYMDESGGRYVQVIADGGMGDSGSFVKALALGADAVMLGAPLARATEAPGKGTHWGSEARHQTLPRGSRTTVG
TVGPLEQVLFGPSHQADGKTNFIGALKRAMASTGYVDVKNFQRCGMVVNPYSAR
>Mature_373_residues
SQEIEIGLGKKGRLGYALDDVAIVPSRRTRDPEDVSTSWQIDAYEFDVPVIGAPMDSVTSPATAIAMGKMGALGVLDLEG
LWTRYEDPTPLLDEIAGLPADQATERIQQIYAEPVKPELITQRLHEIRAAGVTVAGALSPQRTQQFYSTVVDAGVDLFVI
RGTVVSAEHVSSGQEPLNLKKFIYDLDVPVIVGGASNYTAALHLMRTGAAGVLVGFGGGAVSATRQTIGVQAPMATAIAD
VAEARRDYMDESGGRYVQVIADGGMGDSGSFVKALALGADAVMLGAPLARATEAPGKGTHWGSEARHQTLPRGSRTTVGT
VGPLEQVLFGPSHQADGKTNFIGALKRAMASTGYVDVKNFQRCGMVVNPYSAR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=147, Percent_Identity=37.4149659863946, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI217035152, Length=108, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI217035148, Length=110, Percent_Identity=40, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI34328928, Length=108, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI34328930, Length=108, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217035146, Length=110, Percent_Identity=40, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156616279, Length=108, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI217035150, Length=110, Percent_Identity=40, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994385, Length=178, Percent_Identity=33.1460674157303, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994389, Length=178, Percent_Identity=33.1460674157303, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=150, Percent_Identity=32.6666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323585, Length=150, Percent_Identity=32.6666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322012, Length=152, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641071, Length=111, Percent_Identity=38.7387387387387, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641073, Length=111, Percent_Identity=38.7387387387387, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571163, Length=111, Percent_Identity=38.7387387387387, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39427; Mature: 39296

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEIEIGLGKKGRLGYALDDVAIVPSRRTRDPEDVSTSWQIDAYEFDVPVIGAPMDSVT
CCCCEEECCCCCCCCCEEECCEEECCCCCCCCCCCCCCCEEEEEEEECCCEECCCHHHHC
SPATAIAMGKMGALGVLDLEGLWTRYEDPTPLLDEIAGLPADQATERIQQIYAEPVKPEL
CCHHHHHHCCCCCCEEEECCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
ITQRLHEIRAAGVTVAGALSPQRTQQFYSTVVDAGVDLFVIRGTVVSAEHVSSGQEPLNL
HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECEEEEHHHHCCCCCCCCH
KKFIYDLDVPVIVGGASNYTAALHLMRTGAAGVLVGFGGGAVSATRQTIGVQAPMATAIA
HHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHH
DVAEARRDYMDESGGRYVQVIADGGMGDSGSFVKALALGADAVMLGAPLARATEAPGKGT
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHCCCHHHHCCCCCCCC
HWGSEARHQTLPRGSRTTVGTVGPLEQVLFGPSHQADGKTNFIGALKRAMASTGYVDVKN
CCCCHHHHHCCCCCCCCEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEECCC
FQRCGMVVNPYSAR
HHHCCCEECCCCCC
>Mature Secondary Structure 
SQEIEIGLGKKGRLGYALDDVAIVPSRRTRDPEDVSTSWQIDAYEFDVPVIGAPMDSVT
CCCEEECCCCCCCCCEEECCEEECCCCCCCCCCCCCCCEEEEEEEECCCEECCCHHHHC
SPATAIAMGKMGALGVLDLEGLWTRYEDPTPLLDEIAGLPADQATERIQQIYAEPVKPEL
CCHHHHHHCCCCCCEEEECCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
ITQRLHEIRAAGVTVAGALSPQRTQQFYSTVVDAGVDLFVIRGTVVSAEHVSSGQEPLNL
HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECEEEEHHHHCCCCCCCCH
KKFIYDLDVPVIVGGASNYTAALHLMRTGAAGVLVGFGGGAVSATRQTIGVQAPMATAIA
HHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHH
DVAEARRDYMDESGGRYVQVIADGGMGDSGSFVKALALGADAVMLGAPLARATEAPGKGT
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHHCCCHHHHCCCCCCCC
HWGSEARHQTLPRGSRTTVGTVGPLEQVLFGPSHQADGKTNFIGALKRAMASTGYVDVKN
CCCCHHHHHCCCCCCCCEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEECCC
FQRCGMVVNPYSAR
HHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA