BacMap

Definition	Bifidobacterium longum subsp. infantis ATCC 15697, complete genome.
Accession	NC_011593
Length	2,832,748

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The map label for this gene is yqhE [C]

Identifier: 213691715

GI number: 213691715

Start: 966547

End: 967374

Strand: Reverse

Name: yqhE [C]

Synonym: Blon_0820

Alternate gene names: 213691715

Gene position: 967374-966547 (Counterclockwise)

Preceding gene: 213691730

Following gene: 213691711

Centisome position: 34.15

GC content: 55.43

Gene sequence:

>828_bases
ATGGCAATTCAATCGACAATTATGCTGAACAACGGCACTGTCATCCCGCAGGTGGGCTTGGGCGTATTCCAGACACCGGA
TGGTGATACTACAGTGAACGCGGTGCAGACGGCTCTGGAGAATGGCTACCGTCATATCGATACCGCAATGATTTACCGCA
ACGAAGCCTCAGTAGGTGAAGGTATTCGCCGTGCTGGTGTGCCGCGCAGCGATTTCTTCTTGACCACCAAGCTGTGGAAT
GACGATATTCGCGCACGCCACGGCAAGGATGCATTCCAAGAAAGCCTCGACCGCTTGGGCGTGGATTATGTGGATCTGTA
TCTGATTCACTGGCCGGCAGACGGCTGGCAGCAGGCCTGGGATGACTTGCAGGAGATTTATGCCTCTGGCCGTGCCAAGG
CCATTGGCGTCAGTAACTTCCAAAAGCATCATATTGATGAGCTGCTGACCCACAGCGATATGGTGCCTGCCGTAGACCAG
ATTGAGTCTTCCCCACAATTCACCAATCAAGAGCTCATTGGCCAGCTGCGTGCCAAGGGCATCGCAACCGAGGCTTGGAG
TCCGCTCGGCGGTACCGGCGGCAACCTGCTGAGCAACCCAGTATTGGCCGAGATCGGTGCCAAGTACGGCAAGTCACCTG
CCCAAGTGGTGATTCGCTGGCACATCCAGCGCGGCATCGTCGTGCTGCCCAAGTCCACCCATGCCGAGCGTATCAAGCAG
AACTTCGAGGTCTTCGACTTCAACCTAACAGTCGATGATATGACCGCCATTTCCGCCATCAACACCGGCAAGCGCAACGG
TGCCGATCCTGACAATTTCAATTTCTAG

Upstream 100 bases:

>100_bases
CGCCATCATTACGCAATTCTTTGCCCGCGAAACGCGGCTCATTGCATCGTCTTGTTTCTAAAATAGGAAATTGAATGAAC
ACTACGAATAGTGAGGCATT

Downstream 100 bases:

>100_bases
ACCTTTATAGGTCCAGATACGCAAAGAGGGAACTCTCCGTCACTTGAGGGTTCCCTCTTCTATATGCTTACGATTCGGCC
GCACCCTAGTTGCGAGAGCC

Product: 2,5-didehydrogluconate reductase

Products: 2-keto-L-gulonate; NADP [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MAIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGEGIRRAGVPRSDFFLTTKLWN
DDIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAWDDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQ
IESSPQFTNQELIGQLRAKGIATEAWSPLGGTGGNLLSNPVLAEIGAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQ
NFEVFDFNLTVDDMTAISAINTGKRNGADPDNFNF

Sequences:

>Translated_275_residues
MAIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGEGIRRAGVPRSDFFLTTKLWN
DDIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAWDDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQ
IESSPQFTNQELIGQLRAKGIATEAWSPLGGTGGNLLSNPVLAEIGAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQ
NFEVFDFNLTVDDMTAISAINTGKRNGADPDNFNF
>Mature_274_residues
AIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGEGIRRAGVPRSDFFLTTKLWND
DIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAWDDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQI
ESSPQFTNQELIGQLRAKGIATEAWSPLGGTGGNLLSNPVLAEIGAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQN
FEVFDFNLTVDDMTAISAINTGKRNGADPDNFNF

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=35.9322033898305, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=35.9322033898305, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=36.271186440678, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI310109922, Length=292, Percent_Identity=34.9315068493151, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI5453543, Length=313, Percent_Identity=32.9073482428115, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI310109920, Length=313, Percent_Identity=32.9073482428115, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI45446745, Length=313, Percent_Identity=32.9073482428115, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI4503285, Length=313, Percent_Identity=32.9073482428115, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=34.2105263157895, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4502049, Length=302, Percent_Identity=38.0794701986755, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI24497583, Length=294, Percent_Identity=32.9931972789116, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI5174695, Length=303, Percent_Identity=34.3234323432343, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=31.986531986532, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI291291012, Length=268, Percent_Identity=35.0746268656716, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=35, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI300116273, Length=282, Percent_Identity=32.9787234042553, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI310109924, Length=169, Percent_Identity=33.7278106508876, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=39.8230088495575, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=39.8230088495575, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI87082198, Length=276, Percent_Identity=43.8405797101449, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1786400, Length=257, Percent_Identity=35.7976653696498, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788081, Length=279, Percent_Identity=26.8817204301075, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787674, Length=269, Percent_Identity=26.7657992565056, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71998625, Length=278, Percent_Identity=34.8920863309352, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=33.6996336996337, Blast_Score=173, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=32.6530612244898, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17537075, Length=294, Percent_Identity=32.312925170068, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=32.5503355704698, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=30.03663003663, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17550248, Length=294, Percent_Identity=32.312925170068, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17537079, Length=306, Percent_Identity=32.6797385620915, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=31.5972222222222, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=31.1594202898551, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17538386, Length=271, Percent_Identity=29.8892988929889, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=26.8115942028986, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324694, Length=289, Percent_Identity=43.598615916955, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320576, Length=288, Percent_Identity=40.9722222222222, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322556, Length=258, Percent_Identity=37.5968992248062, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=33.974358974359, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319625, Length=291, Percent_Identity=32.3024054982818, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=33.2155477031802, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24657054, Length=288, Percent_Identity=37.1527777777778, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=32.2147651006711, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21356425, Length=288, Percent_Identity=35.0694444444444, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=34, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=32.8813559322034, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45553081, Length=299, Percent_Identity=32.4414715719064, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=31.875, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20129731, Length=290, Percent_Identity=33.1034482758621, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24662785, Length=277, Percent_Identity=37.9061371841155, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24662781, Length=283, Percent_Identity=37.8091872791519, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=31.7829457364341, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30401; Mature: 30270

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGE
CCCCEEEEECCCEECCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHEEEECCCHHHH
GIRRAGVPRSDFFLTTKLWNDDIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAW
HHHHCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHH
DDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQIESSPQFTNQELIGQLRAKG
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCC
IATEAWSPLGGTGGNLLSNPVLAEIGAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQ
CCHHCCCCCCCCCCCHHCCHHHHHHHHHHCCCHHHEEEEEEECCCEEEEECCHHHHHHHC
NFEVFDFNLTVDDMTAISAINTGKRNGADPDNFNF
CCEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIQSTIMLNNGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGE
CCCEEEEECCCEECCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHEEEECCCHHHH
GIRRAGVPRSDFFLTTKLWNDDIRARHGKDAFQESLDRLGVDYVDLYLIHWPADGWQQAW
HHHHCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHH
DDLQEIYASGRAKAIGVSNFQKHHIDELLTHSDMVPAVDQIESSPQFTNQELIGQLRAKG
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCC
IATEAWSPLGGTGGNLLSNPVLAEIGAKYGKSPAQVVIRWHIQRGIVVLPKSTHAERIKQ
CCHHCCCCCCCCCCCHHCCHHHHHHHHHHCCCHHHEEEEEEECCCEEEEECCHHHHHHHC
NFEVFDFNLTVDDMTAISAINTGKRNGADPDNFNF
CCEEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2,5-diketo-D-gluconate; NADPH [C]

Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA