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The map label for this gene is dxr [H]

Identifier: 213691674

GI number: 213691674

Start: 902779

End: 903969

Strand: Direct

Name: dxr [H]

Synonym: Blon_0779

Alternate gene names: 213691674

Gene position: 902779-903969 (Clockwise)

Preceding gene: 213691673

Following gene: 213691675

Centisome position: 31.87

GC content: 62.22

Gene sequence:

>1191_bases
GTGAGCATAGCCTCCAACTCCACCGTCATCATTCTCGGATCCACTGGATCCATCGGCACCCAAGGACTTGACGTCATCGC
GCGTCACCCTGAACGATTTACCGTCACCGGTCTGGCGGCGGGCGGAGCACATATCGAGCTGCTGGCGCAACAGGCCGCAC
AGTTCCATGTGTCCGAAGTCGCGGTGTTTGATGAGACCAAGATTCCAGCACTGCAAGCAGCTCTCGCACAGGCCGGCGCA
CAAGGTGTCCGCGTGACCGGCGGTCCGGATTCGGTCATCGCCATGGCCGGATCCGGTGCGAATGTCGTATTGAACGGCAT
CACCGGCTCCATCGGCCTCGAACCGTCGATCGCGGCGCTCAAGGCCGGTTCCCAGCTGGCATTGGCCAACAAGGAGTCCG
TAGTCGCGGGCGGTCATCTGCTGTTCAGCGCCCAAGTACGCGAGAACCAGATCAACCCGGTCGATTCCGAACATTCCGCC
ATCTGGCAATCCCTGCGCTCCGGAACCCACGCCGAAGTCGCCAAGCTTGTGGTCACCGCCTCCGGCGGACCGTTCCGCGG
TTGGAAACGTGCCGACATGGAGAACATCACTCCCGAGCAGGCGCTGCATCATCCGACGTGGAACATGGGGCCGGTTGTCA
CCATCAACTCCTCCACGCTGATGAACAAGGGGCTCGAAGTCATCGAGGCGTCCCGCTTGTTCGACGTTCCGCCTGAACGC
ATCGACGTGACCGTGCACCCGCAGTCCATCGTCCATTCCATGGTCGAATTTGTGGACGGCGCCACGATTTGCCAGGCTTC
GCCGCCGGACATGCGTCTGCCCATCGCGCTGGGCCTGTCCGCGCCGGACCGCATGGCCAATGTGGCCGCCGCGTGCGACT
GGACGAAAGCCGCAACTTGGACCTTTGAACCGTTGGACGATGAGGCGTTCCCCGCCGTGCAACTGGCCCGTCACTGCCTG
GCCGCCTCCGAGAAGCATACGGCGGTGCTGAATGCGGCCAATGAACAGGCCGTGCATGCCTTCCTCGAGCATCGTCTGCC
ATACCTCGGCATCGTGGACACGGTCAAAGCCGTGCTGGACCAGATGGACGCCGAGCTTCGTGGTAACCCGCTGTTCACGG
ACGTGGAGGAAATGAACCAACTTGAGCTTGAAGCCCGCCGACGCGCCGACGACCTGATAAACAAGCAATGA

Upstream 100 bases:

>100_bases
ATTCGTTCCCGCTGCTGTTCCCGCTTGTCGGTAACTTCGATTCGGATATCCCCGACCTGTCGTTCCCCACACTGAACAAT
GACGATACGAAGAAGGAACA

Downstream 100 bases:

>100_bases
TGAATACCTTGAATACGGAAAATCCCATCGAAAAGCCGTTCCGCAAAACCGGTGATCCGGTCGATCTGACCAGCGAATCG
CCCTTGCACCCGCGCCGCAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSIASNSTVIILGSTGSIGTQGLDVIARHPERFTVTGLAAGGAHIELLAQQAAQFHVSEVAVFDETKIPALQAALAQAGA
QGVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAALKAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSA
IWQSLRSGTHAEVAKLVVTASGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVPPER
IDVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMANVAAACDWTKAATWTFEPLDDEAFPAVQLARHCL
AASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLDQMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ

Sequences:

>Translated_396_residues
MSIASNSTVIILGSTGSIGTQGLDVIARHPERFTVTGLAAGGAHIELLAQQAAQFHVSEVAVFDETKIPALQAALAQAGA
QGVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAALKAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSA
IWQSLRSGTHAEVAKLVVTASGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVPPER
IDVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMANVAAACDWTKAATWTFEPLDDEAFPAVQLARHCL
AASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLDQMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ
>Mature_395_residues
SIASNSTVIILGSTGSIGTQGLDVIARHPERFTVTGLAAGGAHIELLAQQAAQFHVSEVAVFDETKIPALQAALAQAGAQ
GVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAALKAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSAI
WQSLRSGTHAEVAKLVVTASGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVPPERI
DVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMANVAAACDWTKAATWTFEPLDDEAFPAVQLARHCLA
ASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLDQMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=366, Percent_Identity=37.7049180327869, Blast_Score=232, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41983; Mature: 41852

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIASNSTVIILGSTGSIGTQGLDVIARHPERFTVTGLAAGGAHIELLAQQAAQFHVSEV
CCCCCCCEEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHE
AVFDETKIPALQAALAQAGAQGVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAAL
EEECCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHH
KAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSAIWQSLRSGTHAEVAKLVVTA
CCCCEEEECCCCCEEECCEEEEEEEHHCCCCCCCCCHHHHHHHHHHCCCHHHEEEEEEEE
SGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVPPER
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHHHHCCCCCCC
IDVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMANVAAACDWTKAATW
EEEEECHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEE
TFEPLDDEAFPAVQLARHCLAASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLD
EECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHH
QMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIASNSTVIILGSTGSIGTQGLDVIARHPERFTVTGLAAGGAHIELLAQQAAQFHVSEV
CCCCCCEEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHE
AVFDETKIPALQAALAQAGAQGVRVTGGPDSVIAMAGSGANVVLNGITGSIGLEPSIAAL
EEECCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHH
KAGSQLALANKESVVAGGHLLFSAQVRENQINPVDSEHSAIWQSLRSGTHAEVAKLVVTA
CCCCEEEECCCCCEEECCEEEEEEEHHCCCCCCCCCHHHHHHHHHHCCCHHHEEEEEEEE
SGGPFRGWKRADMENITPEQALHHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVPPER
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHHHHCCCCCCC
IDVTVHPQSIVHSMVEFVDGATICQASPPDMRLPIALGLSAPDRMANVAAACDWTKAATW
EEEEECHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEE
TFEPLDDEAFPAVQLARHCLAASEKHTAVLNAANEQAVHAFLEHRLPYLGIVDTVKAVLD
EECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHH
QMDAELRGNPLFTDVEEMNQLELEARRRADDLINKQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA