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The map label for this gene is metC [H]

Identifier: 213691644

GI number: 213691644

Start: 868917

End: 870149

Strand: Direct

Name: metC [H]

Synonym: Blon_0748

Alternate gene names: 213691644

Gene position: 868917-870149 (Clockwise)

Preceding gene: 213691643

Following gene: 213691645

Centisome position: 30.67

GC content: 60.67

Gene sequence:

>1233_bases
ATGACCAGATTCAATACTCAGCTCGTTCACGGACTGCCGGTTGACGACAATGACACCGGAGCAGTGAATCCGCCGATCTA
CAATTCGACGACATATGCCTTTGAGAGGGTCGATGCGATGCCCCGCTACGATTACGCGCGCAGCGGCAACCCCACGCGTG
ATTTCCTGGAGCGGCAGATCGCCCAGCTTGAACAGGGAAAGCGTGGTTTTGCGTTCGCCTCCGGTCTGGCTGCGATCCAT
GCGGTGCTCAGTACCTTCAAGCCCGGCGACCGTATCGTCGTGGGAGACAATATCTACGGTGGAACGTACTCGCAGCTCAA
TGAGTTCTTCACCCGTTGGGGGCTTGTGGTCGAATCGGTCAATACCAGGGATGACGCCGCTTTGGAGTCCGCAGTGCGGG
GCGATCGCGCGAACGGCGTCGCGCCCGCCCGGGCCGTCTATTTCGAGACCCTGACCAATCCGCTGCTCAAGGTCAATGAC
GTGCGCGCCATCTCCGCGACGGCGCATCGTCACGGCGCATTGTCCATCGTGGACAACACGTTCGCGACCCCGTACCTGCA
GCAGCCGCTTTCCCTCGGCGCGGATGTGGTGATTCATTCCGCCACCAAGTACTTGGCCGGCCACTCCGACGTCAATGCCG
GTCTTGTGGTCGTATCCAGTGAGGATCTGGCCAATCGCGTGTACTTCGCGCAGAATCGTCTCGGTGGGGTCCTGGCGCCC
GCCGAATGTGATTCGGTGCGTCGCGGCATACAGACGTTGGCCTTGCGTATGGATCGTCAGCAGGAAAACGCGAACGCCCT
CGCCCGGTATCTGCTCGCTCACCCATTGGTCAAATCCGTTCACTATCCAGGATTGCCCGGTGCCGGCGATCAGCGGCTCG
CAGCCAAGGGGTTGAAGGGCGCCGGCGGCGTGCTGAGCTTCGAAGTGGTGCCTGGCGTGGACCCTGCGGATGTGCTCAAC
AACCTGCACATCTTCCGATTGGCTGTGTCCCTTGGTGCCGTGGAATCGCTTGCGGAACTGCCTTGCCGCATGACGCATTT
CGAACTGCCCCGGGAGGAGCGTCTGAAGGTCGGCATCACCGATGAGCTGGTGCGTCTCGCCGTCGGCATCGAGGATGCGA
ACGATCTGATCGAAGACCTCGGACAGGCTTTCGATATCGCCTATGCCCGATACAGGGAACGCCACATCGACTCCGATGTA
CTTGGCGCATTGACTCCGAAGGTGTTCGCTTGA

Upstream 100 bases:

>100_bases
TAGCAACGCCGGCCTTCGGGCCGGCGTTCTGCATTACAGTCATATATGTGGCGCGGGGGAGTCCCGTGCACGGATGACGC
GACACGTAAGGGGGTGCGCA

Downstream 100 bases:

>100_bases
CGTGATATGGCCGTATGTGCCGTTACGATGGATGCGATGGGAAGCCGCGGACGAAGCGCGGCGCGCAGAAAGGACATGGC
ATGGCCATTGATGTGTACGG

Product: Cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTRFNTQLVHGLPVDDNDTGAVNPPIYNSTTYAFERVDAMPRYDYARSGNPTRDFLERQIAQLEQGKRGFAFASGLAAIH
AVLSTFKPGDRIVVGDNIYGGTYSQLNEFFTRWGLVVESVNTRDDAALESAVRGDRANGVAPARAVYFETLTNPLLKVND
VRAISATAHRHGALSIVDNTFATPYLQQPLSLGADVVIHSATKYLAGHSDVNAGLVVVSSEDLANRVYFAQNRLGGVLAP
AECDSVRRGIQTLALRMDRQQENANALARYLLAHPLVKSVHYPGLPGAGDQRLAAKGLKGAGGVLSFEVVPGVDPADVLN
NLHIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGITDELVRLAVGIEDANDLIEDLGQAFDIAYARYRERHIDSDV
LGALTPKVFA

Sequences:

>Translated_410_residues
MTRFNTQLVHGLPVDDNDTGAVNPPIYNSTTYAFERVDAMPRYDYARSGNPTRDFLERQIAQLEQGKRGFAFASGLAAIH
AVLSTFKPGDRIVVGDNIYGGTYSQLNEFFTRWGLVVESVNTRDDAALESAVRGDRANGVAPARAVYFETLTNPLLKVND
VRAISATAHRHGALSIVDNTFATPYLQQPLSLGADVVIHSATKYLAGHSDVNAGLVVVSSEDLANRVYFAQNRLGGVLAP
AECDSVRRGIQTLALRMDRQQENANALARYLLAHPLVKSVHYPGLPGAGDQRLAAKGLKGAGGVLSFEVVPGVDPADVLN
NLHIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGITDELVRLAVGIEDANDLIEDLGQAFDIAYARYRERHIDSDV
LGALTPKVFA
>Mature_409_residues
TRFNTQLVHGLPVDDNDTGAVNPPIYNSTTYAFERVDAMPRYDYARSGNPTRDFLERQIAQLEQGKRGFAFASGLAAIHA
VLSTFKPGDRIVVGDNIYGGTYSQLNEFFTRWGLVVESVNTRDDAALESAVRGDRANGVAPARAVYFETLTNPLLKVNDV
RAISATAHRHGALSIVDNTFATPYLQQPLSLGADVVIHSATKYLAGHSDVNAGLVVVSSEDLANRVYFAQNRLGGVLAPA
ECDSVRRGIQTLALRMDRQQENANALARYLLAHPLVKSVHYPGLPGAGDQRLAAKGLKGAGGVLSFEVVPGVDPADVLNN
LHIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGITDELVRLAVGIEDANDLIEDLGQAFDIAYARYRERHIDSDVL
GALTPKVFA

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=389, Percent_Identity=41.6452442159383, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI299473759, Length=393, Percent_Identity=37.6590330788804, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI25453487, Length=388, Percent_Identity=37.1134020618557, Blast_Score=224, Evalue=8e-59,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=40.6914893617021, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1789383, Length=401, Percent_Identity=27.431421446384, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17560056, Length=390, Percent_Identity=43.8461538461538, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17538055, Length=393, Percent_Identity=42.2391857506361, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71980708, Length=387, Percent_Identity=36.1757105943152, Blast_Score=234, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6319307, Length=400, Percent_Identity=36.75, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6323333, Length=420, Percent_Identity=34.7619047619048, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321254, Length=424, Percent_Identity=32.5471698113208, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321904, Length=401, Percent_Identity=29.1770573566085, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321170, Length=327, Percent_Identity=27.217125382263, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922554, Length=388, Percent_Identity=42.7835051546392, Blast_Score=296, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44533; Mature: 44402

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFNTQLVHGLPVDDNDTGAVNPPIYNSTTYAFERVDAMPRYDYARSGNPTRDFLERQI
CCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AQLEQGKRGFAFASGLAAIHAVLSTFKPGDRIVVGDNIYGGTYSQLNEFFTRWGLVVESV
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
NTRDDAALESAVRGDRANGVAPARAVYFETLTNPLLKVNDVRAISATAHRHGALSIVDNT
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCEEEECCC
FATPYLQQPLSLGADVVIHSATKYLAGHSDVNAGLVVVSSEDLANRVYFAQNRLGGVLAP
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEECC
AECDSVRRGIQTLALRMDRQQENANALARYLLAHPLVKSVHYPGLPGAGDQRLAAKGLKG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
AGGVLSFEVVPGVDPADVLNNLHIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGIT
CCCEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCEEECCH
DELVRLAVGIEDANDLIEDLGQAFDIAYARYRERHIDSDVLGALTPKVFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCC
>Mature Secondary Structure 
TRFNTQLVHGLPVDDNDTGAVNPPIYNSTTYAFERVDAMPRYDYARSGNPTRDFLERQI
CCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AQLEQGKRGFAFASGLAAIHAVLSTFKPGDRIVVGDNIYGGTYSQLNEFFTRWGLVVESV
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
NTRDDAALESAVRGDRANGVAPARAVYFETLTNPLLKVNDVRAISATAHRHGALSIVDNT
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCEEEECCC
FATPYLQQPLSLGADVVIHSATKYLAGHSDVNAGLVVVSSEDLANRVYFAQNRLGGVLAP
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEECC
AECDSVRRGIQTLALRMDRQQENANALARYLLAHPLVKSVHYPGLPGAGDQRLAAKGLKG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
AGGVLSFEVVPGVDPADVLNNLHIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGIT
CCCEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCEEECCH
DELVRLAVGIEDANDLIEDLGQAFDIAYARYRERHIDSDVLGALTPKVFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]