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The map label for this gene is uxuB [H]

Identifier: 213691566

GI number: 213691566

Start: 771940

End: 773334

Strand: Reverse

Name: uxuB [H]

Synonym: Blon_0668

Alternate gene names: 213691566

Gene position: 773334-771940 (Counterclockwise)

Preceding gene: 213691567

Following gene: 213691565

Centisome position: 27.3

GC content: 60.86

Gene sequence:

>1395_bases
ATGACTGATACACATGATTTCACGTCATTGCCCAGATTGAACCGCGCAGAGCACGGCCGCGCCGCAGCGCCGGTGCGCAT
CATCCATCTTGGTATCGGCAATTTCACCAGGGCGCATCAAGCCTGGTACACGGAACATGCGCCGGACACCGCGCAGTGGG
GCATCGCCGGTTTCACCGGACGTTCTCGCCGAATGGTCGACAAGCTGGCCCCTCAGGACAACGTCTACACGCTGATCACC
TCGGCACCGGAAGGCGATTCGTTCGAAGTCATCTCTTCGATTTCATCGATGCATGAGGGCGGCGACATGGCGGCACTGCA
CAAGTACTTCGCGGATCCGAACGTGTCCATCGTCACCTCCACGGTTACCGAAGCTGGATACAAAAGGAACGCCCACGGTG
ATCTAGATGTCAACGACACCGACGTGTCGGAGGACCTCGCCAAACTGCGTAACGATGTGAACGTGTCCGAACTTGCCACC
GTGCCTGCACGCATTGTGGCCGGGCTGGAGGCGCGTCGCGCGGCAAACGCCGGAGCGATCACTATCCTTCCCTGCGACAA
CCTCGCAGGCAACGGAGCCGCGTTCCGTCGCGTCGTCGAGCAGGCCATTGAGGCCGTGGACCCCACCTTGCTGGAATGGA
CTCGCGACAACGTGGCATGGGCCACTTCGATGGTCGACCGCATCACGCCGGCCACCACCGACGCCGAACTGCAGACCGTG
GCACAGGACGAGGGATGGTACGACGTGGCGCCGGTGCGCACGGAACCGTTCCTCGAATGGGTCATCCGAGGCGACTTCCC
GAAGGGACGTCCTGCATGGGACAAGGCCGGTGCCGTTATCACGGATGATGTGGAACCCTACGAGCAGCGCAAACTGTGGA
TGCTCAATGGTTCGCATTCCACTCTCGCCTATGTCGGCCCGCTGTTCGGTCATGAGTCGGTGGCCGAGGCCATCGCTGAC
CCGCAGCTGCGGGCATGGGTGAATGAATGGTGGGATCTGGCCGGATCATACCTGTCCGTCTCCAGTGACGACTACCGTGC
CAAGCTGTTGGAGCGATTCTCCAATCCGCGCATTCACCATCACCTTTTCCAAATCGCCACCGATGGTTCGCAAAAGCTGC
CGGTACGAATCGTGCCTGTCGCCAAGCACGCGCTTGCGGACGGTCGCGACATCACGGCTCCGGCACGTGCTGTCGCCGCA
TGGATCGTGTTCCTGCGTCGATTTGGAAACACGGAGGCCAAGGACGTGAATCTCGACGAGGTGAGGAAACTTGCCGTCAA
CGATGACGTCACCCCAGCCGTGTCCTACCTGGACAAGGATCTTGGCGCCAACGCCACTTTCACCAACAAGGTGAGCGAAC
TCGTCAACGAGCTGTCTTCGGCGACAGCCGCGTGA

Upstream 100 bases:

>100_bases
AGGAAGGCGAGCAGATCGCCATTCGTTCCGTGGACGGTCAGCCTTCTGACGTGTTCAAGCTCTGACTCGAACGACCTTTT
ATTGATTTCAAGGAGTAAAT

Downstream 100 bases:

>100_bases
CCACAACCATAAACATAATCAAATAACCGATAGCATAAGCTTCCTCGCCGTAGGTGGGGATTATGACGCGGACGCGCCGC
GTCATAACAGGAAGGAATAA

Product: Mannitol dehydrogenase, C-terminal domain protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTDTHDFTSLPRLNRAEHGRAAAPVRIIHLGIGNFTRAHQAWYTEHAPDTAQWGIAGFTGRSRRMVDKLAPQDNVYTLIT
SAPEGDSFEVISSISSMHEGGDMAALHKYFADPNVSIVTSTVTEAGYKRNAHGDLDVNDTDVSEDLAKLRNDVNVSELAT
VPARIVAGLEARRAANAGAITILPCDNLAGNGAAFRRVVEQAIEAVDPTLLEWTRDNVAWATSMVDRITPATTDAELQTV
AQDEGWYDVAPVRTEPFLEWVIRGDFPKGRPAWDKAGAVITDDVEPYEQRKLWMLNGSHSTLAYVGPLFGHESVAEAIAD
PQLRAWVNEWWDLAGSYLSVSSDDYRAKLLERFSNPRIHHHLFQIATDGSQKLPVRIVPVAKHALADGRDITAPARAVAA
WIVFLRRFGNTEAKDVNLDEVRKLAVNDDVTPAVSYLDKDLGANATFTNKVSELVNELSSATAA

Sequences:

>Translated_464_residues
MTDTHDFTSLPRLNRAEHGRAAAPVRIIHLGIGNFTRAHQAWYTEHAPDTAQWGIAGFTGRSRRMVDKLAPQDNVYTLIT
SAPEGDSFEVISSISSMHEGGDMAALHKYFADPNVSIVTSTVTEAGYKRNAHGDLDVNDTDVSEDLAKLRNDVNVSELAT
VPARIVAGLEARRAANAGAITILPCDNLAGNGAAFRRVVEQAIEAVDPTLLEWTRDNVAWATSMVDRITPATTDAELQTV
AQDEGWYDVAPVRTEPFLEWVIRGDFPKGRPAWDKAGAVITDDVEPYEQRKLWMLNGSHSTLAYVGPLFGHESVAEAIAD
PQLRAWVNEWWDLAGSYLSVSSDDYRAKLLERFSNPRIHHHLFQIATDGSQKLPVRIVPVAKHALADGRDITAPARAVAA
WIVFLRRFGNTEAKDVNLDEVRKLAVNDDVTPAVSYLDKDLGANATFTNKVSELVNELSSATAA
>Mature_463_residues
TDTHDFTSLPRLNRAEHGRAAAPVRIIHLGIGNFTRAHQAWYTEHAPDTAQWGIAGFTGRSRRMVDKLAPQDNVYTLITS
APEGDSFEVISSISSMHEGGDMAALHKYFADPNVSIVTSTVTEAGYKRNAHGDLDVNDTDVSEDLAKLRNDVNVSELATV
PARIVAGLEARRAANAGAITILPCDNLAGNGAAFRRVVEQAIEAVDPTLLEWTRDNVAWATSMVDRITPATTDAELQTVA
QDEGWYDVAPVRTEPFLEWVIRGDFPKGRPAWDKAGAVITDDVEPYEQRKLWMLNGSHSTLAYVGPLFGHESVAEAIADP
QLRAWVNEWWDLAGSYLSVSSDDYRAKLLERFSNPRIHHHLFQIATDGSQKLPVRIVPVAKHALADGRDITAPARAVAAW
IVFLRRFGNTEAKDVNLDEVRKLAVNDDVTPAVSYLDKDLGANATFTNKVSELVNELSSATAA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=456, Percent_Identity=35.5263157894737, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1787823, Length=394, Percent_Identity=37.3096446700508, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788497, Length=413, Percent_Identity=33.6561743341404, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI48994885, Length=436, Percent_Identity=27.7522935779816, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790028, Length=294, Percent_Identity=25.1700680272109, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=395, Percent_Identity=32.4050632911392, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6320765, Length=395, Percent_Identity=32.4050632911392, Blast_Score=189, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 50869; Mature: 50738

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTHDFTSLPRLNRAEHGRAAAPVRIIHLGIGNFTRAHQAWYTEHAPDTAQWGIAGFTG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
RSRRMVDKLAPQDNVYTLITSAPEGDSFEVISSISSMHEGGDMAALHKYFADPNVSIVTS
CHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEH
TVTEAGYKRNAHGDLDVNDTDVSEDLAKLRNDVNVSELATVPARIVAGLEARRAANAGAI
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
TILPCDNLAGNGAAFRRVVEQAIEAVDPTLLEWTRDNVAWATSMVDRITPATTDAELQTV
EEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHH
AQDEGWYDVAPVRTEPFLEWVIRGDFPKGRPAWDKAGAVITDDVEPYEQRKLWMLNGSHS
HCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCHHCCEEEEEECCCC
TLAYVGPLFGHESVAEAIADPQLRAWVNEWWDLAGSYLSVSSDDYRAKLLERFSNPRIHH
CHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCHHH
HLFQIATDGSQKLPVRIVPVAKHALADGRDITAPARAVAAWIVFLRRFGNTEAKDVNLDE
HHHHHCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VRKLAVNDDVTPAVSYLDKDLGANATFTNKVSELVNELSSATAA
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDTHDFTSLPRLNRAEHGRAAAPVRIIHLGIGNFTRAHQAWYTEHAPDTAQWGIAGFTG
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
RSRRMVDKLAPQDNVYTLITSAPEGDSFEVISSISSMHEGGDMAALHKYFADPNVSIVTS
CHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEH
TVTEAGYKRNAHGDLDVNDTDVSEDLAKLRNDVNVSELATVPARIVAGLEARRAANAGAI
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
TILPCDNLAGNGAAFRRVVEQAIEAVDPTLLEWTRDNVAWATSMVDRITPATTDAELQTV
EEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHH
AQDEGWYDVAPVRTEPFLEWVIRGDFPKGRPAWDKAGAVITDDVEPYEQRKLWMLNGSHS
HCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCHHCCEEEEEECCCC
TLAYVGPLFGHESVAEAIADPQLRAWVNEWWDLAGSYLSVSSDDYRAKLLERFSNPRIHH
CHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCHHH
HLFQIATDGSQKLPVRIVPVAKHALADGRDITAPARAVAAWIVFLRRFGNTEAKDVNLDE
HHHHHCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VRKLAVNDDVTPAVSYLDKDLGANATFTNKVSELVNELSSATAA
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]