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The map label for this gene is livH [H]

Identifier: 213691481

GI number: 213691481

Start: 653691

End: 654614

Strand: Direct

Name: livH [H]

Synonym: Blon_0578

Alternate gene names: 213691481

Gene position: 653691-654614 (Clockwise)

Preceding gene: 213691480

Following gene: 213691482

Centisome position: 23.08

GC content: 58.12

Gene sequence:

>924_bases
ATGGATCAAATCATCATGTTTGTCAGCCAGTTGTTCAATGGCCTGAAAATAGGCAGCGTGTACGCGCTGGTGGCATTGGG
CTACACCATGGTCTACGGCATTATTCGACTGATTAACTTCGCCCACGGCGATTTCATCATGGTCGGTGCCTATGTGCTGA
TGCTCACCATTCCCGCAATCGTCGCTATGGGACTGCCCGCCTGGGTGGCGGTCATTCCCGCCGTTCTGGTTTGTGTGGCC
GTCGGTGTCATCGTCGAAAAGGCCGCGTACAAGCCGGTGCGTGAAAAGGGCAATTCCATGACGGCCCTGATTACCGCCAT
CGCCATGTCGCTGTTGCTGGAGAACGGTTCCCAAGCCGTCTTCGGCGCCGACTTCCAGACCGTGCCGACTATCTTCCACC
TGCCATCCATCGCGTTCGGCAAGCTGAAACTGCCGGGTGACACCCTGCTGACCATCGTCATCGGCCTGGTCATCATGGCC
GGTCTGCAACTGTTCGTCAAATTCACTCGCCAAGGCAAGGCCATGCGCGCCGTTTCCGAAGACAAGGAAGCCGCCGTGCT
CATGGGCATTAATGTGAACTCCACCATTGCCCTGACCTTCGCCATCGGCTCCGGCTTGGCCGCAGTCGCCTCGCTGATGT
ACTGCGCCGCCTACCCACAAGTCTCCCCGATGATGGGCGCCATGCTGGGTCTTAAGGCATTCGTCGCCGCCGTGCTCGGC
GGCATTGGTTCCATTCCCGGTGCCATGATCGGTGGTCTGGCCATCGGACTGATCGAAAGCCTCACCAAGGCCTATATCGG
TACCATTACGGGCGGCATCATCACCTCGGCATTCTCCGATGCCATCGTGTTCGCCATCCTGATCATTGTGTTGCTCGTCA
AACCGTCCGGCATCATGGGCAAGAACGAAGGGGAGAAGGTCTGA

Upstream 100 bases:

>100_bases
GCGTCGTACGGTGCCACATTATTCGCAATAGATATACCAATAATTCTGCGCATTCATCGCAGACAACAATCGAAATACTT
ACAAGAAAGGGGGAGCAGTG

Downstream 100 bases:

>100_bases
TCCGATGAAGAAGACAATGCTTTCCACCAAACAGTCCTATCTGGTGTGCTTCATCGGCGTCCTTGCCGCATTCGGCGTTG
TGATGGCGCTGTGCGAATCC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDQIIMFVSQLFNGLKIGSVYALVALGYTMVYGIIRLINFAHGDFIMVGAYVLMLTIPAIVAMGLPAWVAVIPAVLVCVA
VGVIVEKAAYKPVREKGNSMTALITAIAMSLLLENGSQAVFGADFQTVPTIFHLPSIAFGKLKLPGDTLLTIVIGLVIMA
GLQLFVKFTRQGKAMRAVSEDKEAAVLMGINVNSTIALTFAIGSGLAAVASLMYCAAYPQVSPMMGAMLGLKAFVAAVLG
GIGSIPGAMIGGLAIGLIESLTKAYIGTITGGIITSAFSDAIVFAILIIVLLVKPSGIMGKNEGEKV

Sequences:

>Translated_307_residues
MDQIIMFVSQLFNGLKIGSVYALVALGYTMVYGIIRLINFAHGDFIMVGAYVLMLTIPAIVAMGLPAWVAVIPAVLVCVA
VGVIVEKAAYKPVREKGNSMTALITAIAMSLLLENGSQAVFGADFQTVPTIFHLPSIAFGKLKLPGDTLLTIVIGLVIMA
GLQLFVKFTRQGKAMRAVSEDKEAAVLMGINVNSTIALTFAIGSGLAAVASLMYCAAYPQVSPMMGAMLGLKAFVAAVLG
GIGSIPGAMIGGLAIGLIESLTKAYIGTITGGIITSAFSDAIVFAILIIVLLVKPSGIMGKNEGEKV
>Mature_307_residues
MDQIIMFVSQLFNGLKIGSVYALVALGYTMVYGIIRLINFAHGDFIMVGAYVLMLTIPAIVAMGLPAWVAVIPAVLVCVA
VGVIVEKAAYKPVREKGNSMTALITAIAMSLLLENGSQAVFGADFQTVPTIFHLPSIAFGKLKLPGDTLLTIVIGLVIMA
GLQLFVKFTRQGKAMRAVSEDKEAAVLMGINVNSTIALTFAIGSGLAAVASLMYCAAYPQVSPMMGAMLGLKAFVAAVLG
GIGSIPGAMIGGLAIGLIESLTKAYIGTITGGIITSAFSDAIVFAILIIVLLVKPSGIMGKNEGEKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=315, Percent_Identity=43.4920634920635, Blast_Score=229, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31861; Mature: 31861

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQIIMFVSQLFNGLKIGSVYALVALGYTMVYGIIRLINFAHGDFIMVGAYVLMLTIPAI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAMGLPAWVAVIPAVLVCVAVGVIVEKAAYKPVREKGNSMTALITAIAMSLLLENGSQAV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
FGADFQTVPTIFHLPSIAFGKLKLPGDTLLTIVIGLVIMAGLQLFVKFTRQGKAMRAVSE
ECCCCHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
DKEAAVLMGINVNSTIALTFAIGSGLAAVASLMYCAAYPQVSPMMGAMLGLKAFVAAVLG
CCCCEEEEECCCCCEEEEEEEHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GIGSIPGAMIGGLAIGLIESLTKAYIGTITGGIITSAFSDAIVFAILIIVLLVKPSGIMG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KNEGEKV
CCCCCCC
>Mature Secondary Structure
MDQIIMFVSQLFNGLKIGSVYALVALGYTMVYGIIRLINFAHGDFIMVGAYVLMLTIPAI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAMGLPAWVAVIPAVLVCVAVGVIVEKAAYKPVREKGNSMTALITAIAMSLLLENGSQAV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
FGADFQTVPTIFHLPSIAFGKLKLPGDTLLTIVIGLVIMAGLQLFVKFTRQGKAMRAVSE
ECCCCHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
DKEAAVLMGINVNSTIALTFAIGSGLAAVASLMYCAAYPQVSPMMGAMLGLKAFVAAVLG
CCCCEEEEECCCCCEEEEEEEHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GIGSIPGAMIGGLAIGLIESLTKAYIGTITGGIITSAFSDAIVFAILIIVLLVKPSGIMG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KNEGEKV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]