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The map label for this gene is tmk

Identifier: 213691095

GI number: 213691095

Start: 208333

End: 209034

Strand: Direct

Name: tmk

Synonym: Blon_0174

Alternate gene names: 213691095

Gene position: 208333-209034 (Clockwise)

Preceding gene: 213691094

Following gene: 213691096

Centisome position: 7.35

GC content: 61.4

Gene sequence:

>702_bases
ATGAGCGGTCTGTTTGTTTCGTTTGAAGGTGTCGATGGCGTGGGCAAGACCACGCAAGTCGAGCGACTGCGTGCGTATCT
TGAGGCTCAGGGGCGTACCGTGGTCGTTACCCGTGAGCCGGGAGGCACTGTGTTAGGCAAGGCCATTCGCCAACTGCTGT
TGCACGGTGTGGATGGGGGCGCCGTCGACATCGCACCGCGCGCCGAGGCGTTGCTATTCGCTGCAGACCGAGCCCAGCAC
GTTGCCGAAACCATCCGCCCGGCATTGGAGCGCGGTGAAGTGGTGATCACCGACCGCTATCTAGACTCTTCCTTGGCCTA
TCAGGCCGGTGGCCGCGAACTCACGCCAGAAGAGATTCGATCCTTAAGCATGTGGGCCACCAACAACCTGCTGCCCGACC
GCACATATCTGCTGGACATGGATCCGGCGCTTTCCCACAATCGTCTTGAGCATGCCGAAGATCGCATGGAGTCGGCCGGC
AGCGACTTCCAGTCCCGCACCCGTCAGGCGTTCCTCGACTTGGCCGCGGCCGAGCCGAATCGTTTCCACGTGATCGATGC
CAGCCAGTCCATCGAACAGGTGTGGTCCGCCATCGAAGCGGACATTCAGACACTGCTGCGGGACAATGTTGCAGATGTGG
ATACGGTGATGGCGCGATCCGGGGCGTCTACAGGAGCCGTGACGATGGGCGGTGTCCGATGA

Upstream 100 bases:

>100_bases
AGACCTTCAGAAAAGACCAAATCAGCCCCTTGAAACGGAGGTAGAGCTGGTTTAACTGCCTGTTGGGCGCAACTCTGCGC
CTAACGCTAAGGTCAATAGC

Downstream 100 bases:

>100_bases
GCGTATGGGATTCACTAGTCGGCCAGCAGCCGGTAATCGACATGTTCAGTCGCATCGCGCAGGGCGACCCGGGGCAGATC
ACCCAGTCGTGGCTGATTTG

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTVLGKAIRQLLLHGVDGGAVDIAPRAEALLFAADRAQH
VAETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIRSLSMWATNNLLPDRTYLLDMDPALSHNRLEHAEDRMESAG
SDFQSRTRQAFLDLAAAEPNRFHVIDASQSIEQVWSAIEADIQTLLRDNVADVDTVMARSGASTGAVTMGGVR

Sequences:

>Translated_233_residues
MSGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTVLGKAIRQLLLHGVDGGAVDIAPRAEALLFAADRAQH
VAETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIRSLSMWATNNLLPDRTYLLDMDPALSHNRLEHAEDRMESAG
SDFQSRTRQAFLDLAAAEPNRFHVIDASQSIEQVWSAIEADIQTLLRDNVADVDTVMARSGASTGAVTMGGVR
>Mature_232_residues
SGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTVLGKAIRQLLLHGVDGGAVDIAPRAEALLFAADRAQHV
AETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIRSLSMWATNNLLPDRTYLLDMDPALSHNRLEHAEDRMESAGS
DFQSRTRQAFLDLAAAEPNRFHVIDASQSIEQVWSAIEADIQTLLRDNVADVDTVMARSGASTGAVTMGGVR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=39.0243902439024, Blast_Score=117, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28573735, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BIFLI (B7GT80)

Other databases:

- EMBL:   CP001095
- RefSeq:   YP_002321681.1
- GeneID:   7055616
- GenomeReviews:   CP001095_GR
- KEGG:   bln:Blon_0174
- HOGENOM:   HBG626009
- ProtClustDB:   CLSK572651
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25304; Mature: 25173

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTVLGKAIRQLLLHGVDGG
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
AVDIAPRAEALLFAADRAQHVAETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCHHHHHCCCCCCCHHHHH
SLSMWATNNLLPDRTYLLDMDPALSHNRLEHAEDRMESAGSDFQSRTRQAFLDLAAAEPN
HHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
RFHVIDASQSIEQVWSAIEADIQTLLRDNVADVDTVMARSGASTGAVTMGGVR
EEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCCC
>Mature Secondary Structure 
SGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTVLGKAIRQLLLHGVDGG
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
AVDIAPRAEALLFAADRAQHVAETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCHHHHHCCCCCCCHHHHH
SLSMWATNNLLPDRTYLLDMDPALSHNRLEHAEDRMESAGSDFQSRTRQAFLDLAAAEPN
HHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
RFHVIDASQSIEQVWSAIEADIQTLLRDNVADVDTVMARSGASTGAVTMGGVR
EEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA