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The map label for this gene is scrR [H]

Identifier: 213691048

GI number: 213691048

Start: 148831

End: 149916

Strand: Direct

Name: scrR [H]

Synonym: Blon_0127

Alternate gene names: 213691048

Gene position: 148831-149916 (Clockwise)

Preceding gene: 213691047

Following gene: 213691049

Centisome position: 5.25

GC content: 57.55

Gene sequence:

>1086_bases
ATGGTCGGCATGCGCGATGTGGCGAAGAAGGCCGGGGTGTCTCTGAGCACCGTCTCGCTGGTGGTGAACGGCAACGGGTA
CGTGTCTGATGACATGCGCGAACGTGTGCGCAAAGCCATGCAACTGCTCAATTATGTGCCGAACGAGCTTGCCCGCAATC
TGTATCATGATCGCACGAATCTGGTCGGCGTCATCGTGCCCACCATCCGCCACCCGTTCTTTGCGACGTTTACCGCACAT
CTGCAGCATGCGCTCGCCGCGCAAGGATTACGCACTATGTTGTGCTCTACCGCAGATGAGGCGGACGGCGAAATCCAGTA
TGTCGACATGTTGCGTCGGCACATGATGGACGGCATCGTCATGTGTGCGCACACTTCGCATCCCGGCGATTATTGGACGT
CGATTCATCGCCCGATCGTCGCGTTCGACCGTGTGCTTGGAGACGGTATTTCGTCGATTGGATCCGACCACGAGCAGGGT
GGGCGATTGATTGCGCAGATGCTGATCCGCAATGGTACCAAACATGTGGTGATGATTGGCGGTCCGCGAGATCAATTCTT
CGATTTGGCTGCGCGCGGAGAAGTCGAGGAAGGACCGTTCGATTTGGGAAAGACCACGTTCCCGACGGTGCGCTATTACC
TCACGTTGGAACAGGAATTGACCTCCGCAGGCGTGAAATACGAGTACGTTGAAGCTGGCGAAGTGATGGATTTTGCCGGC
TATCATCGTGCGGTCAGCAATGCGCTCGACAAGGTGACGACCGACGGCGTCGATGCCGTGGTCAGTTCCGATATTGGCGC
GTCGTTCTGCGTGCGCGAAGCGTTGAGCCGCGGAATTCCCATTCCTGACGAGCTGCAGATCGTTGCCTACGATGGTACGT
ATTTGACTGATTTGGCCGGCATGAAGCTGACCGCGGTCGCGCAGGATTTCTCGGCGATCGCACAGTCGGCGGCCGACCAT
ATCGTGCAGGCTATTGCCAATGAGGAAGTGGCTGCGGCTAACGCTTCACGCAGGAACATCCCCAAGCCGTTCGAGCCGAA
TGTGCTTATTCCCATGACGCTGGTGCCAGGCGATACCACGCGTTGA

Upstream 100 bases:

>100_bases
ACTGTCGAACAGGTTCGAGAGAATGTAAATGAATGTAATATTTCGTGGTAAGCACGTGAGAATACGGCGATAGAACAGTG
ATGACGGGGAAGGTGCGATC

Downstream 100 bases:

>100_bases
TGCTGCGCGTTGGAACGCTGAGTGGGGATCGGACAGGCTGGGTTGTGTAGAACACCGCATCAAACCGGTTCGACACGCGC
ATTTTGCGGTATTACTGGAC

Product: regulatory protein, LacI

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTNLVGVIVPTIRHPFFATFTAH
LQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIVMCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQG
GRLIAQMLIRNGTKHVVMIGGPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIPIPDELQIVAYDGTYLTDLAGMKLTAVAQDFSAIAQSAADH
IVQAIANEEVAAANASRRNIPKPFEPNVLIPMTLVPGDTTR

Sequences:

>Translated_361_residues
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTNLVGVIVPTIRHPFFATFTAH
LQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIVMCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQG
GRLIAQMLIRNGTKHVVMIGGPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIPIPDELQIVAYDGTYLTDLAGMKLTAVAQDFSAIAQSAADH
IVQAIANEEVAAANASRRNIPKPFEPNVLIPMTLVPGDTTR
>Mature_361_residues
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTNLVGVIVPTIRHPFFATFTAH
LQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIVMCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQG
GRLIAQMLIRNGTKHVVMIGGPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIPIPDELQIVAYDGTYLTDLAGMKLTAVAQDFSAIAQSAADH
IVQAIANEEVAAANASRRNIPKPFEPNVLIPMTLVPGDTTR

Specific function: Negative regulator of scrB expression [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=189, Percent_Identity=31.2169312169312, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787906, Length=184, Percent_Identity=32.0652173913043, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790369, Length=338, Percent_Identity=23.6686390532544, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789068, Length=297, Percent_Identity=26.2626262626263, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786268, Length=186, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788474, Length=181, Percent_Identity=27.6243093922652, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790715, Length=190, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787580, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789202, Length=175, Percent_Identity=29.7142857142857, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994940, Length=335, Percent_Identity=22.6865671641791, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 39383; Mature: 39383

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTN
CCCHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
LVGVIVPTIRHPFFATFTAHLQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIV
EEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEE
MCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQGGRLIAQMLIRNGTKHVVMIG
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEE
GPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHCCCEEEEECCCCHHHHHH
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIPIPDELQIVAYDGTYLTDLAG
HHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCC
MKLTAVAQDFSAIAQSAADHIVQAIANEEVAAANASRRNIPKPFEPNVLIPMTLVPGDTT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHCCCCCCCCCCEEEEEEECCCCCC
R
C
>Mature Secondary Structure
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTN
CCCHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
LVGVIVPTIRHPFFATFTAHLQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIV
EEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEE
MCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQGGRLIAQMLIRNGTKHVVMIG
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEE
GPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHCCCEEEEECCCCHHHHHH
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIPIPDELQIVAYDGTYLTDLAG
HHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCC
MKLTAVAQDFSAIAQSAADHIVQAIANEEVAAANASRRNIPKPFEPNVLIPMTLVPGDTT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHCCCCCCCCCCEEEEEEECCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9673256; 12397186 [H]