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The map label for this gene is msrAB [H]

Identifier: 213691011

GI number: 213691011

Start: 108731

End: 109705

Strand: Direct

Name: msrAB [H]

Synonym: Blon_0089

Alternate gene names: 213691011

Gene position: 108731-109705 (Clockwise)

Preceding gene: 213691010

Following gene: 213691012

Centisome position: 3.84

GC content: 63.28

Gene sequence:

>975_bases
ATGAGCGAACGTAACGAACACAATGACGGAAATACGCAAACCGCATACTTCGCCGGCGGCTGCTTCTGGGGTCTGGAGCG
CTACTTCCAGAACGTCGACGGCGTCACGGACACCACGGTCGGCTACGCGCAATCCACCGTCGAATCGCCGACCTACGAGC
AGGTATGCGCGGGCGGCACCGATGCGGCCGAAACCGTGAAAGTCGAGTTTGACCCGGCACAGGTCAGCCTGCGGACGCTG
ACATTGCTGTTCCTGGAGGTCATCGACCCGTTCTCCGTGGACCAGCAGGGCGAGGACCGCGGCCGGCAGTACCGCACCGG
CATGTTCTACACGGACGAGACGCAGCGCGCCGTGTATGTGGCGGCTCTGGAGCAGCTGGTCGACCGCCAGCCGCAGCGCC
CGGCCGTACTGGTCGAACCGCTGCGCAACTTCTACCCGGCCGAGGCACACCATCAGGACTATCTGGTGAACAACCCCGGC
GGCTACTGCCATGTACCGATCGCCGCAATCGCGAACGTAAAACGCCGTCAGAAGTACGTGGAACGCATCTGGGATCTGAC
GCTTGAGCAGTTCGCGGTCACGCAGAACGCCGCTACCGAGCGCCCGTTCGTCAACGAGTACGACGAGAAATTCGAGCCCG
GCATCTACGTGGATATCGTCAGTGGCGAGCCGCTGTTCTCGTCGCAAGACAAATTCGATTCCGGCTGCGGCTGGCCCGCG
TTCTCCCGCCCGATTGCCGGTGACTTGCTGACCGAGCATGAGGACCACCGCATTCCGGGCCGCGACCGCATCGAAGTGCG
CACGTCGGACACACAGATTCATCTGGGGCACGTGTTCCCCGACGGGCCGGCCGACCGAGGCGGCCTGCGCTACTGCATGA
ATTCCGCCGCGCTGCGTTTCGTGCCGCGCTCGCGTATGGTTGAGGAAGGCTACGGCGACTGGATTGCGGTTGTGGATGGG
GATGATAAGGCATGA

Upstream 100 bases:

>100_bases
CTCCGGCGGGGGTCAAATCAGCCCCTCGAAAGCGGTTTTGCCGGTGCAGAGGTGTCGTTGACTGCATCGCGAGCCGCCTC
GACGTAGTAACGTGGGGCGT

Downstream 100 bases:

>100_bases
GCATGGAGAATATCGCGGGCGCTCGCAAGCCCGCCAAGCGTGAGGATGAGCACACGGTCGCCGGCGAGCATCGCATGATG
CGCCGTGCGGACCGCGAGGT

Product: methionine-R-sulfoxide reductase

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSERNEHNDGNTQTAYFAGGCFWGLERYFQNVDGVTDTTVGYAQSTVESPTYEQVCAGGTDAAETVKVEFDPAQVSLRTL
TLLFLEVIDPFSVDQQGEDRGRQYRTGMFYTDETQRAVYVAALEQLVDRQPQRPAVLVEPLRNFYPAEAHHQDYLVNNPG
GYCHVPIAAIANVKRRQKYVERIWDLTLEQFAVTQNAATERPFVNEYDEKFEPGIYVDIVSGEPLFSSQDKFDSGCGWPA
FSRPIAGDLLTEHEDHRIPGRDRIEVRTSDTQIHLGHVFPDGPADRGGLRYCMNSAALRFVPRSRMVEEGYGDWIAVVDG
DDKA

Sequences:

>Translated_324_residues
MSERNEHNDGNTQTAYFAGGCFWGLERYFQNVDGVTDTTVGYAQSTVESPTYEQVCAGGTDAAETVKVEFDPAQVSLRTL
TLLFLEVIDPFSVDQQGEDRGRQYRTGMFYTDETQRAVYVAALEQLVDRQPQRPAVLVEPLRNFYPAEAHHQDYLVNNPG
GYCHVPIAAIANVKRRQKYVERIWDLTLEQFAVTQNAATERPFVNEYDEKFEPGIYVDIVSGEPLFSSQDKFDSGCGWPA
FSRPIAGDLLTEHEDHRIPGRDRIEVRTSDTQIHLGHVFPDGPADRGGLRYCMNSAALRFVPRSRMVEEGYGDWIAVVDG
DDKA
>Mature_323_residues
SERNEHNDGNTQTAYFAGGCFWGLERYFQNVDGVTDTTVGYAQSTVESPTYEQVCAGGTDAAETVKVEFDPAQVSLRTLT
LLFLEVIDPFSVDQQGEDRGRQYRTGMFYTDETQRAVYVAALEQLVDRQPQRPAVLVEPLRNFYPAEAHHQDYLVNNPGG
YCHVPIAAIANVKRRQKYVERIWDLTLEQFAVTQNAATERPFVNEYDEKFEPGIYVDIVSGEPLFSSQDKFDSGCGWPAF
SRPIAGDLLTEHEDHRIPGRDRIEVRTSDTQIHLGHVFPDGPADRGGLRYCMNSAALRFVPRSRMVEEGYGDWIAVVDGD
DKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=175, Percent_Identity=36.5714285714286, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.8205128205128, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI301336164, Length=140, Percent_Identity=45.7142857142857, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI301336162, Length=140, Percent_Identity=45.7142857142857, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI73089054, Length=140, Percent_Identity=45.7142857142857, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI37620216, Length=139, Percent_Identity=43.8848920863309, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI117606353, Length=127, Percent_Identity=44.0944881889764, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788077, Length=117, Percent_Identity=46.1538461538462, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=37.5, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=119, Percent_Identity=41.1764705882353, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=115, Percent_Identity=41.7391304347826, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=32.3943661971831, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=170, Percent_Identity=35.2941176470588, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=124, Percent_Identity=37.0967741935484, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221378664, Length=116, Percent_Identity=50, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45553335, Length=116, Percent_Identity=50, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356369, Length=116, Percent_Identity=50, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645799, Length=116, Percent_Identity=50, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645804, Length=127, Percent_Identity=46.4566929133858, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI221378662, Length=123, Percent_Identity=47.1544715447154, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24645801, Length=127, Percent_Identity=46.4566929133858, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=34.6938775510204, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=34.0425531914894, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=34.0136054421769, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 36506; Mature: 36375

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERNEHNDGNTQTAYFAGGCFWGLERYFQNVDGVTDTTVGYAQSTVESPTYEQVCAGGT
CCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHCCCC
DAAETVKVEFDPAQVSLRTLTLLFLEVIDPFSVDQQGEDRGRQYRTGMFYTDETQRAVYV
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEECCCEEECCCHHHHHH
AALEQLVDRQPQRPAVLVEPLRNFYPAEAHHQDYLVNNPGGYCHVPIAAIANVKRRQKYV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHH
ERIWDLTLEQFAVTQNAATERPFVNEYDEKFEPGIYVDIVSGEPLFSSQDKFDSGCGWPA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
FSRPIAGDLLTEHEDHRIPGRDRIEVRTSDTQIHLGHVFPDGPADRGGLRYCMNSAALRF
CCCCCCHHHHCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHEE
VPRSRMVEEGYGDWIAVVDGDDKA
CCHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SERNEHNDGNTQTAYFAGGCFWGLERYFQNVDGVTDTTVGYAQSTVESPTYEQVCAGGT
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHCCCC
DAAETVKVEFDPAQVSLRTLTLLFLEVIDPFSVDQQGEDRGRQYRTGMFYTDETQRAVYV
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEECCCEEECCCHHHHHH
AALEQLVDRQPQRPAVLVEPLRNFYPAEAHHQDYLVNNPGGYCHVPIAAIANVKRRQKYV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHH
ERIWDLTLEQFAVTQNAATERPFVNEYDEKFEPGIYVDIVSGEPLFSSQDKFDSGCGWPA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
FSRPIAGDLLTEHEDHRIPGRDRIEVRTSDTQIHLGHVFPDGPADRGGLRYCMNSAALRF
CCCCCCHHHHCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHEE
VPRSRMVEEGYGDWIAVVDGDDKA
CCHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]