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The map label for this gene is fahA

Identifier: 213159156

GI number: 213159156

Start: 3992987

End: 3994294

Strand: Direct

Name: fahA

Synonym: AB57_3867

Alternate gene names: NA

Gene position: 3992987-3994294 (Clockwise)

Preceding gene: 213159152

Following gene: 213159157

Centisome position: 98.58

GC content: 41.44

Gene sequence:

>1308_bases
ATGGAACAAAAACTAAACTCTTTTATTGAAGTTTCACCTCAATCTGATTTCACTATTCATAATTTGCCTTATGGTATTTT
TAGTAGAACAGCCGAAGGCGAGCGTCAGGTCGGTGTAGCTATCGGTGATTGGGTCATTGATCTCGCTGCTCTTGAAAAGC
ATGGTCTTTTAAAACTTTCAGATCAAGACACCTACTTTAACCAGCCTACACTGAATAAATTTATTGAATCGGGCAAAGCC
AATTGGTCTAAAGTTCGTAAAACGCTACAGTCTCTTCTTTCAGTTGATAATTTAACGCTTCAAGAAAATGAAGCATTGCG
CCAAGAAGTTTTAGTCAAGCAAGACAGCGTGACTTTACATTTACCTATTCAAGTTCCTGGCTATACCGATTTCTATTCTT
CTAAAGAACATGCAACTAATGTAGGCTGTATGTTCCGTGACCCTAAAAATGCCTTGCTTCCAAACTGGAGCGAGTTGCCT
GTCGGTTATAACGGCCGTGCTAGCTCTGTTGTAGTAAGTGGAACTCACGTCGTACGCCCTTCTGGTCAGATTAAACTTCC
AAATGAAGAACGTCCGGTTTTCTCAGCAACTCGCAAGCTCGATTTTGAACTTGAGACTGCATTTATTGTGGGGAAACCAA
CTCAATTAGGTCAACCAATCGCCATTGAAGATGCATGGGATCATATTTTTGGCATGGTTCTGCTAAATGACTGGTCAGCA
CGTGATATCCAACAATGGGAATATGTTCCACTTGGCCCTTTCAACGCTAAAACATTTGCAAGTTCGATTTCTCCTTGGGT
CGTCACACTTGAAGCTCTTGAGCCATTTAAAGTTGAAGGTCCGAAACAAGAACCGAAGCCACTTGCTTATTTACAAGAAA
ATATCGCCAATACTTACGATATTAATTTAAGTGTTGAAATCCAAAGCCCGAAATCAGCACAACCTGATGTGATCTGCCGT
ACTAATTTTAAATATATGTATTGGTCTATGGCTCAGCAGCTGACTCACCACACCATTGGAGGCTGTAACGTTCAGGTTGG
TGATTTAATGGGTTCAGGTACTATCTCAGGTTCTACACCTGACTCTTATGGTAGCTTGCTTGAGTTGACTTGGAACACCA
CCAAGCCTCTAACACTTGCGAATGGTGAAACTCGTGGTTTCTTGCAAGACGGCGACACACTCATCATGAAAGGCCACTGT
GAGAAAAATGGTATCCGTATTGGTTTTGGTGAAGTCCGAAATACGGTACTTCCTGCATTAACTTTTGATTTTGCAGAAAC
TTCGGAGCCTAATTATGAAGCTGTATAG

Upstream 100 bases:

>100_bases
AAAAGATGATCTAAATAACGGTTAAAACTTATTGAGTAGCTCAGTCCCTAGACCGAACTTTTATTTGTATAAGACGCGAG
ATGAAGACAAGGAAGCGAAA

Downstream 100 bases:

>100_bases
TTACTTTCGTAGCTCTGCAGCTTACAGAGTACGGATTGGTCTCAACCTTAAAAGTCTCGCTTATGAAACTGTACCCGTTC
ATTTGGTTAAAAATGAGCAG

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MEQKLNSFIEVSPQSDFTIHNLPYGIFSRTAEGERQVGVAIGDWVIDLAALEKHGLLKLSDQDTYFNQPTLNKFIESGKA
NWSKVRKTLQSLLSVDNLTLQENEALRQEVLVKQDSVTLHLPIQVPGYTDFYSSKEHATNVGCMFRDPKNALLPNWSELP
VGYNGRASSVVVSGTHVVRPSGQIKLPNEERPVFSATRKLDFELETAFIVGKPTQLGQPIAIEDAWDHIFGMVLLNDWSA
RDIQQWEYVPLGPFNAKTFASSISPWVVTLEALEPFKVEGPKQEPKPLAYLQENIANTYDINLSVEIQSPKSAQPDVICR
TNFKYMYWSMAQQLTHHTIGGCNVQVGDLMGSGTISGSTPDSYGSLLELTWNTTKPLTLANGETRGFLQDGDTLIMKGHC
EKNGIRIGFGEVRNTVLPALTFDFAETSEPNYEAV

Sequences:

>Translated_435_residues
MEQKLNSFIEVSPQSDFTIHNLPYGIFSRTAEGERQVGVAIGDWVIDLAALEKHGLLKLSDQDTYFNQPTLNKFIESGKA
NWSKVRKTLQSLLSVDNLTLQENEALRQEVLVKQDSVTLHLPIQVPGYTDFYSSKEHATNVGCMFRDPKNALLPNWSELP
VGYNGRASSVVVSGTHVVRPSGQIKLPNEERPVFSATRKLDFELETAFIVGKPTQLGQPIAIEDAWDHIFGMVLLNDWSA
RDIQQWEYVPLGPFNAKTFASSISPWVVTLEALEPFKVEGPKQEPKPLAYLQENIANTYDINLSVEIQSPKSAQPDVICR
TNFKYMYWSMAQQLTHHTIGGCNVQVGDLMGSGTISGSTPDSYGSLLELTWNTTKPLTLANGETRGFLQDGDTLIMKGHC
EKNGIRIGFGEVRNTVLPALTFDFAETSEPNYEAV
>Mature_435_residues
MEQKLNSFIEVSPQSDFTIHNLPYGIFSRTAEGERQVGVAIGDWVIDLAALEKHGLLKLSDQDTYFNQPTLNKFIESGKA
NWSKVRKTLQSLLSVDNLTLQENEALRQEVLVKQDSVTLHLPIQVPGYTDFYSSKEHATNVGCMFRDPKNALLPNWSELP
VGYNGRASSVVVSGTHVVRPSGQIKLPNEERPVFSATRKLDFELETAFIVGKPTQLGQPIAIEDAWDHIFGMVLLNDWSA
RDIQQWEYVPLGPFNAKTFASSISPWVVTLEALEPFKVEGPKQEPKPLAYLQENIANTYDINLSVEIQSPKSAQPDVICR
TNFKYMYWSMAQQLTHHTIGGCNVQVGDLMGSGTISGSTPDSYGSLLELTWNTTKPLTLANGETRGFLQDGDTLIMKGHC
EKNGIRIGFGEVRNTVLPALTFDFAETSEPNYEAV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=416, Percent_Identity=55.7692307692308, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=53.5885167464115, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24657182, Length=414, Percent_Identity=52.8985507246377, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 48428; Mature: 48428

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKLNSFIEVSPQSDFTIHNLPYGIFSRTAEGERQVGVAIGDWVIDLAALEKHGLLKLS
CCCHHCCCEEECCCCCEEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEC
DQDTYFNQPTLNKFIESGKANWSKVRKTLQSLLSVDNLTLQENEALRQEVLVKQDSVTLH
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCHHHHHHHHHEECCCEEEE
LPIQVPGYTDFYSSKEHATNVGCMFRDPKNALLPNWSELPVGYNGRASSVVVSGTHVVRP
EEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCEEEEECEEEECC
SGQIKLPNEERPVFSATRKLDFELETAFIVGKPTQLGQPIAIEDAWDHIFGMVLLNDWSA
CCCEECCCCCCCHHHHHHEECEEEEEEEEEECCHHCCCCEEEEHHHHHHEEEEEECCCCC
RDIQQWEYVPLGPFNAKTFASSISPWVVTLEALEPFKVEGPKQEPKPLAYLQENIANTYD
CCCCCCCEEECCCCCHHHHHHCCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHCCCEEE
INLSVEIQSPKSAQPDVICRTNFKYMYWSMAQQLTHHTIGGCNVQVGDLMGSGTISGSTP
EEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCCCCC
DSYGSLLELTWNTTKPLTLANGETRGFLQDGDTLIMKGHCEKNGIRIGFGEVRNTVLPAL
CCCCCEEEEEECCCCCEEEECCCCCCEEECCCEEEEECCCCCCCEEEEHHHHHHHHHHHE
TFDFAETSEPNYEAV
EECCCCCCCCCCCCC
>Mature Secondary Structure
MEQKLNSFIEVSPQSDFTIHNLPYGIFSRTAEGERQVGVAIGDWVIDLAALEKHGLLKLS
CCCHHCCCEEECCCCCEEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEC
DQDTYFNQPTLNKFIESGKANWSKVRKTLQSLLSVDNLTLQENEALRQEVLVKQDSVTLH
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCHHHHHHHHHEECCCEEEE
LPIQVPGYTDFYSSKEHATNVGCMFRDPKNALLPNWSELPVGYNGRASSVVVSGTHVVRP
EEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCEEEEECEEEECC
SGQIKLPNEERPVFSATRKLDFELETAFIVGKPTQLGQPIAIEDAWDHIFGMVLLNDWSA
CCCEECCCCCCCHHHHHHEECEEEEEEEEEECCHHCCCCEEEEHHHHHHEEEEEECCCCC
RDIQQWEYVPLGPFNAKTFASSISPWVVTLEALEPFKVEGPKQEPKPLAYLQENIANTYD
CCCCCCCEEECCCCCHHHHHHCCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHCCCEEE
INLSVEIQSPKSAQPDVICRTNFKYMYWSMAQQLTHHTIGGCNVQVGDLMGSGTISGSTP
EEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCCCCC
DSYGSLLELTWNTTKPLTLANGETRGFLQDGDTLIMKGHCEKNGIRIGFGEVRNTVLPAL
CCCCCEEEEEECCCCCEEEECCCCCCEEECCCEEEEECCCCCCCEEEEHHHHHHHHHHHE
TFDFAETSEPNYEAV
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA