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The map label for this gene is proY [H]

Identifier: 213159147

GI number: 213159147

Start: 3981130

End: 3982542

Strand: Reverse

Name: proY [H]

Synonym: AB57_3858

Alternate gene names: 213159147

Gene position: 3982542-3981130 (Counterclockwise)

Preceding gene: 213159148

Following gene: 213159146

Centisome position: 98.32

GC content: 43.03

Gene sequence:

>1413_bases
ATGTCACAAAACTCCACACTACAGCGGGGCTTAAACACCCGCCACATTCGTTTCTTGGCATTGGGCTCAGCAATTGGAAC
TGGGCTTTTCTATGGTTCGGCAACTGCTATTAAAATGGCAGGGCCTTCAGTATTACTTGCGTACATCGTTGCAGGGATTG
CAATTTATATTGTGATGCGCGCACTGGGTGAAATGGCAGTCCATAATCCTGTCTCTGGCTCATTTAGCCACTATGCTTCT
CAATACATTGGTCCTTTGGCCGGCTTTACGACAGGCTGGACTTATGTTTTTGAGATGGTGATTGTTGCAATTGCCGATGT
CACTGCGTTTGGTATTTATATGGGGTTCTGGTATCCCGATGTCCCACGGTGGATCTGGATTTTGTCTCTCATCATGTTCT
TGGGCGCAATTAACCTCATTCATGTGAAAGTCTTTGGTGAACTCGAATTTTGGCTCTCAATTGTCAAGGTGAGTGCCATT
GTTGCCATGATTTTAGGTGGCTTAGGTTTGATGTTCTATGGCTTCCATGCTGACCATAGCAGTGTAGTTCCGGGGATTCA
AAACTTATGGATTTATGAAGGCTTTATGCCACATGGCATTGCAGGCTTGGTTGCATGTTTATCTGTAGTGGTATTTGCTT
TCGGTGGTATCGAAATTATTGGTATTACAGCAGGTGAATCACAAGACCCGAAAACCACTTTACCGAAAGCAATTAATGCT
GTTCCGGTACGTATTTTACTTTTCTATGTACTAACCATCTTTGTACTCATGTCGATTTTCCCATGGAACCAGATTGGTAG
CCAAGGCAGTCCGTTTGTACAAATTTTTGAAAACTTAGGCATTAAATCTGCTGCAAATATTTTAAATATTGTGGTGGTAA
CTGCTGCAATTTCGGCAATTAACAGTGATGTGTTTGGTGCAGGTCGTATGTTGTACGGTATGGCAAATCGTGGTCAAGCA
CCTCGAATTTTCCAAAAATTATCGCGTAATAGTGTGCCTTGGATGACTGTCGTGGTTATGGCTGGCGTGCTGTTAATTGG
TGTGGTGCTGAACTACCTGATTCCTGAAAATGTGTTTGTCATCATTGCATCAATTGCAACGTTTGCAACTGTTTGGGTAT
GGCTCATGATCTTGCTTTCGCAAGTGGCTATGCGCCGTAAATTATCTACAGCTGAAATTAAGGCACTTGATTTCCCTGTA
TTTGGCTGGCCATATGCCCCTGCTTTTGCAATCGGTTTTATGGTGTTCATTTTAGTGATGATGGGCTACTTCCCAGATTC
GCGTCCTGCAATTTATGTAGGAATCACTTGGCTTGCTCTCTTAACTATTGCTTATCGTATTTGGGTAAAACCAGAGCAAA
GCTTGGGAAAGGAAAGTGAGCCTGTCCAGCAAAACATAGAAATGGAAAGCTAA

Upstream 100 bases:

>100_bases
ATTCCAAAACTACTCCCTAGTTTATCTGAAGTGTGATTGATAAAACGGTCACATGGAGTGGCCGAATCCAACTAAATTTC
CTCAAGGATTGGAGATTATA

Downstream 100 bases:

>100_bases
CAAATCAGCTGCCCAATAGTTTTACTGTTGGGCAGTTTCGAGGATAGGCTAATGAAAAAACTTTGGCAAAACTGCCATAT
TGCCACCATGCAAAATGGGC

Product: proline-specific permease ProY

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSQNSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMRALGEMAVHNPVSGSFSHYAS
QYIGPLAGFTTGWTYVFEMVIVAIADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAI
VAMILGGLGLMFYGFHADHSSVVPGIQNLWIYEGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIKSAANILNIVVVTAAISAINSDVFGAGRMLYGMANRGQA
PRIFQKLSRNSVPWMTVVVMAGVLLIGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPV
FGWPYAPAFAIGFMVFILVMMGYFPDSRPAIYVGITWLALLTIAYRIWVKPEQSLGKESEPVQQNIEMES

Sequences:

>Translated_470_residues
MSQNSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMRALGEMAVHNPVSGSFSHYAS
QYIGPLAGFTTGWTYVFEMVIVAIADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAI
VAMILGGLGLMFYGFHADHSSVVPGIQNLWIYEGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIKSAANILNIVVVTAAISAINSDVFGAGRMLYGMANRGQA
PRIFQKLSRNSVPWMTVVVMAGVLLIGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPV
FGWPYAPAFAIGFMVFILVMMGYFPDSRPAIYVGITWLALLTIAYRIWVKPEQSLGKESEPVQQNIEMES
>Mature_469_residues
SQNSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMRALGEMAVHNPVSGSFSHYASQ
YIGPLAGFTTGWTYVFEMVIVAIADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAIV
AMILGGLGLMFYGFHADHSSVVPGIQNLWIYEGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINAV
PVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIKSAANILNIVVVTAAISAINSDVFGAGRMLYGMANRGQAP
RIFQKLSRNSVPWMTVVVMAGVLLIGVVLNYLIPENVFVIIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPVF
GWPYAPAFAIGFMVFILVMMGYFPDSRPAIYVGITWLALLTIAYRIWVKPEQSLGKESEPVQQNIEMES

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=358, Percent_Identity=25.6983240223464, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71999149, Length=342, Percent_Identity=23.3918128654971, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=24.8603351955307, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786602, Length=462, Percent_Identity=59.5238095238095, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=42.9844097995546, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=42.9515418502203, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=43.2372505543237, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=38.9261744966443, Blast_Score=331, Evalue=7e-92,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=36.9458128078818, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=35.8208955223881, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=36.8298368298368, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788480, Length=474, Percent_Identity=34.5991561181435, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87081869, Length=217, Percent_Identity=23.5023041474654, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082023, Length=312, Percent_Identity=21.474358974359, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=338, Percent_Identity=23.3727810650888, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=341, Percent_Identity=24.3401759530792, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=443, Percent_Identity=26.1851015801354, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=32.7272727272727, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=31.5192743764172, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=457, Percent_Identity=30.4157549234136, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=453, Percent_Identity=30.4635761589404, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=29.4117647058824, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=28.7410926365796, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=437, Percent_Identity=25.4004576659039, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=30.8457711442786, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=434, Percent_Identity=26.036866359447, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=414, Percent_Identity=27.536231884058, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=408, Percent_Identity=26.4705882352941, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=24.009900990099, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=25.5, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=409, Percent_Identity=25.1833740831296, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=437, Percent_Identity=24.9427917620137, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=388, Percent_Identity=28.3505154639175, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=398, Percent_Identity=24.8743718592965, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=502, Percent_Identity=25.0996015936255, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24667468, Length=421, Percent_Identity=24.2280285035629, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077963, Length=366, Percent_Identity=26.2295081967213, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24668806, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356285, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24668802, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51450; Mature: 51319

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMR
CCCCCHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
ALGEMAVHNPVSGSFSHYASQYIGPLAGFTTGWTYVFEMVIVAIADVTAFGIYMGFWYPD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAIVAMILGGLGLMFYGFHADHS
HHHHHHHHHHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SVVPGIQNLWIYEGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
CCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIKSAANILNIVVVTAAISAI
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
NSDVFGAGRMLYGMANRGQAPRIFQKLSRNSVPWMTVVVMAGVLLIGVVLNYLIPENVFV
CCCHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPVFGWPYAPAFAIGFMVFILVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MGYFPDSRPAIYVGITWLALLTIAYRIWVKPEQSLGKESEPVQQNIEMES
HHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
SQNSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMR
CCCCHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
ALGEMAVHNPVSGSFSHYASQYIGPLAGFTTGWTYVFEMVIVAIADVTAFGIYMGFWYPD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAIVAMILGGLGLMFYGFHADHS
HHHHHHHHHHHHHHCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SVVPGIQNLWIYEGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
CCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIKSAANILNIVVVTAAISAI
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
NSDVFGAGRMLYGMANRGQAPRIFQKLSRNSVPWMTVVVMAGVLLIGVVLNYLIPENVFV
CCCHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPVFGWPYAPAFAIGFMVFILVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MGYFPDSRPAIYVGITWLALLTIAYRIWVKPEQSLGKESEPVQQNIEMES
HHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]