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The map label for this gene is murC

Identifier: 213159076

GI number: 213159076

Start: 3904927

End: 3906375

Strand: Reverse

Name: murC

Synonym: AB57_3786

Alternate gene names: 213159076

Gene position: 3906375-3904927 (Counterclockwise)

Preceding gene: 213159077

Following gene: 213159075

Centisome position: 96.44

GC content: 41.89

Gene sequence:

>1449_bases
ATGTCTCCAACAACAGCTGCGAACCAAGCAAAAAAACTGATTAAAGTGCCTGAAATGCGCCGTATCAAACACATTCATTT
TGTGGGAATTGGCGGTGCAGGTATGTGTGGTATTGCTGAGGTGTTAGCTAACCAAGGATATAAAATTTCCGGTTCAGATA
TTAAGGCATCAAAAACCACACAACAATTAGAAGAAAATGGCATTAAGGTCTATATCGGACACGAAGCAGAAAATATTAAA
AATGCAAATGTGCTTGTCGTGTCAACAGCAATTGACCCGGAAAATCCGGAAGTTAAAGCTGCCATTGAACAACGTATTCC
GATTGTACGTCGTGCAGAAATGCTCGGTGAACTTATGCGTTACCGTCATGGTATTGCTGTGGCAGGTACACATGGTAAAA
CTACAACCACAAGTCTTTTGACGACAATGTTGGCGGAAGAAAACCTCGACCCAACTTATGTGATCGGTGGTTTACTTAAC
AGTACAGGCGTAAATGCAGCACTGGGTGAAAGCCGCTTTATTGTTGCTGAAGCTGACGAATCGGATGCATCTTTCCTTTA
TTTACAGCCAATGGCAGCGATTGTAACCAACATTGATGCTGACCATATGGATACTTATGAAGGCAGTTTCGATAAATTAA
AAGATACCTTCGTACAGTTCCTTCATAACTTACCATTCTACGGCTTGGCTGTGGTTTGTGGCGATGATGCGAACATCCGC
GAGATTTTGCCACGTGTAGGCCGTCCGGTTATTACTTATGGTTTTAATGAAGATAATGACATCCGTGCTATCGATGTAGA
GCAAGATGGTATGCGTTCGCACTTTACTGTTTTACGTAAAGGACGTGAGCCGTTACGTCTAACTATTAATCAACCGGGTT
TACATAACGTTTTAAATGCTTTGGCTGCAATTGGTGTTGCAACTGATGAAGGCGTTTCGGATGAAGCAATTAGCCGTGCA
TTAAAAGGTTTTAGTGGTGTTGGACGTCGCTTCCAAGTACAAGGTGAATTTGAACTTGGTGAAGGGAATGTAAAATTAGT
CGATGACTATGGGCATCATCCTAAAGAAGTGGAAGCTACGATTAAAGCTGCTCGTCAGAGCCATCCTGATCGTCGTTTAG
TTATGCTTTTCCAACCACACCGTTACTCTCGTACACGTGATTGTTTTGATGACTTTATTGAAGTTTTATCTCAAGTCGAC
CAATTATTATTACTAGAAGTTTATCCGGCTGGGGAAAAACCAATTGTTGGCGCAGATAGCCGTACTTTGGCGCGTAGTAT
TCGCTTGCGTGGTCAGGTTGAACCGATTTTGATTGATCCGGTTGAAGGTAATTTGCAAAACATCATGCAAAATGTGTTAC
AACCAAATGACTTGTTATTAACGCAAGGTGCAGGTAACGTGGGAGCAATTTCAGTAGAACTTGCACAGCACCATTTGTAT
GTGAAATAA

Upstream 100 bases:

>100_bases
AATTACTTACAGAAATGGCAGTGAAAGCGCGTCAACATGCCCAACCAAATGCAACTCAGCATGTGGTTGATCTTATCCAA
AAAATGTAATCGGATTTACT

Downstream 100 bases:

>100_bases
AACAAAAAGTATTGAATTATCGGGTTAAGGATTTAAACGTGTCAAATGCTACAAAATTCGGCAAAGTTGCCGTGTTACTT
GGTGGGAAATCGGCTGAGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIK
NANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLN
STGVNAALGESRFIVAEADESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIR
EILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRA
LKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVD
QLLLLEVYPAGEKPIVGADSRTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLY
VK

Sequences:

>Translated_482_residues
MSPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIK
NANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLN
STGVNAALGESRFIVAEADESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIR
EILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRA
LKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVD
QLLLLEVYPAGEKPIVGADSRTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLY
VK
>Mature_481_residues
SPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTTQQLEENGIKVYIGHEAENIKN
ANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNS
TGVNAALGESRFIVAEADESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIRE
ILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRAL
KGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQ
LLLLEVYPAGEKPIVGADSRTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLYV
K

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=62.6609442060086, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=29.247311827957, Blast_Score=165, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ACIB3 (B7GV74)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002324087.1
- ProteinModelPortal:   B7GV74
- SMR:   B7GV74
- GeneID:   7058979
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_000146
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52883; Mature: 52752

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTT
CCCCCHHHHHHHHHCCCCHHHEEEEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCHHHH
QQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMR
HHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADE
HHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCC
SDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIR
CCCCEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHH
EILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNA
HHHHHCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEAT
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHH
IKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADS
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCH
RTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLY
HHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCEE
VK
CC
>Mature Secondary Structure 
SPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDIKASKTT
CCCCHHHHHHHHHCCCCHHHEEEEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCHHHH
QQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMR
HHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADE
HHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCC
SDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIR
CCCCEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHH
EILPRVGRPVITYGFNEDNDIRAIDVEQDGMRSHFTVLRKGREPLRLTINQPGLHNVLNA
HHHHHCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEAT
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHH
IKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADS
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCH
RTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLY
HHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCEE
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA