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The map label for this gene is iolS [H]

Identifier: 213159007

GI number: 213159007

Start: 3825114

End: 3826115

Strand: Direct

Name: iolS [H]

Synonym: AB57_3714

Alternate gene names: 213159007

Gene position: 3825114-3826115 (Clockwise)

Preceding gene: 213159006

Following gene: 213159011

Centisome position: 94.44

GC content: 44.01

Gene sequence:

>1002_bases
ATGAAATATAGAACTTTAGGACAAACAGGCGAAAAAGTATCAGCACTTGGTTTAGGTTGCATGGGAATGAGCTTTGCCTA
TGGTGCCTCAGACGACACACAAAGCATTGCAACTCTAGAAAAGGCCTTAGACCTCGGCATTAATTTTTGGGACACTGCCG
ACATGTACGGCAACGGCGCAAACGAAGTTTTGCTCTCAAAAGTTTTAGAAAAACACCGTGACAAAGTGTTCTTGGCGACC
AAATTTGGCTTCCGCTATAAAGAAGATAACCTTAACCCGAAAAACTCTTTAGAGTCTTATATCGACGGCTCACCTGAGTG
GATTAAAGTCGCGGTCGAAAACAGTTTAAGACGCTTAAATACAGATGTGATTGATTTGTATTATGCGCACCGCATAGACC
CAAATGTTCCGGTTGAAGATACCATTGGTGCAATGGCGGACTTGGTCAAACAAGGTAAAGTTCGTTATTTAGGACTCAGT
GAAGCGTCGGCTGAAACTATTCGTAAAGCACATGCGATTCACCCGATTGCAGCGGTTCAACATGAATATTCGCTACTTAC
CCGTGAATTTGAGCAAACCCATTTGCAAACCATTCGTGAGTTAGGCATTAGCCTTGTGCCGTATTCACCTTTATCGCGTG
GTTTAATTACCAATACGCTTGATGTAAATAACCTCGACGAAAATGATTTCCGTCGCCAGTTACCACGTTATCAGGGCGAT
AACTGGAAAAATAACCAAAGCTTGGCGCAAGCATTTAGCGAGTTTGCTCAAAGCAAAAATGCGACAGCGGCTCAACTGGC
TTTGGCTTGGATTTTTGCGCAAGGTGACGACATTATTCCAATTCCGGGTACACGTAAAATCGAGCGACTTGTGGAAAATG
CAGGCGCTGTAGATCTTCATTTAACAGCAGCAGATTTGGCAGAAATTGAAGCGATTATCGCGAGATATCCAAACATGGGC
GCACGCTATAACGCTCAGCAACTTGCTGCGGTCAACCACTAA

Upstream 100 bases:

>100_bases
TTGAATTTTATAATTATTGGTTTGAATGTTATACGTCAGTTTGAACCAAAGCATTTTATAGTTTTTCTACTCAAGTGATT
TTGCAAAAAGAGTGTGAAAA

Downstream 100 bases:

>100_bases
AATATAAGCTATTAAAAAGTCCGACTCAGTGTCGGACTTTTTTATTTAGTCTTTGCTATATGTGCCTTGCTGGCGCCCAC
CCTGCCAGATCGCATCTAAG

Product: aldo-keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKYRTLGQTGEKVSALGLGCMGMSFAYGASDDTQSIATLEKALDLGINFWDTADMYGNGANEVLLSKVLEKHRDKVFLAT
KFGFRYKEDNLNPKNSLESYIDGSPEWIKVAVENSLRRLNTDVIDLYYAHRIDPNVPVEDTIGAMADLVKQGKVRYLGLS
EASAETIRKAHAIHPIAAVQHEYSLLTREFEQTHLQTIRELGISLVPYSPLSRGLITNTLDVNNLDENDFRRQLPRYQGD
NWKNNQSLAQAFSEFAQSKNATAAQLALAWIFAQGDDIIPIPGTRKIERLVENAGAVDLHLTAADLAEIEAIIARYPNMG
ARYNAQQLAAVNH

Sequences:

>Translated_333_residues
MKYRTLGQTGEKVSALGLGCMGMSFAYGASDDTQSIATLEKALDLGINFWDTADMYGNGANEVLLSKVLEKHRDKVFLAT
KFGFRYKEDNLNPKNSLESYIDGSPEWIKVAVENSLRRLNTDVIDLYYAHRIDPNVPVEDTIGAMADLVKQGKVRYLGLS
EASAETIRKAHAIHPIAAVQHEYSLLTREFEQTHLQTIRELGISLVPYSPLSRGLITNTLDVNNLDENDFRRQLPRYQGD
NWKNNQSLAQAFSEFAQSKNATAAQLALAWIFAQGDDIIPIPGTRKIERLVENAGAVDLHLTAADLAEIEAIIARYPNMG
ARYNAQQLAAVNH
>Mature_333_residues
MKYRTLGQTGEKVSALGLGCMGMSFAYGASDDTQSIATLEKALDLGINFWDTADMYGNGANEVLLSKVLEKHRDKVFLAT
KFGFRYKEDNLNPKNSLESYIDGSPEWIKVAVENSLRRLNTDVIDLYYAHRIDPNVPVEDTIGAMADLVKQGKVRYLGLS
EASAETIRKAHAIHPIAAVQHEYSLLTREFEQTHLQTIRELGISLVPYSPLSRGLITNTLDVNNLDENDFRRQLPRYQGD
NWKNNQSLAQAFSEFAQSKNATAAQLALAWIFAQGDDIIPIPGTRKIERLVENAGAVDLHLTAADLAEIEAIIARYPNMG
ARYNAQQLAAVNH

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=340, Percent_Identity=29.4117647058824, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI27436962, Length=340, Percent_Identity=29.1176470588235, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI27436969, Length=340, Percent_Identity=28.5294117647059, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4504825, Length=338, Percent_Identity=28.4023668639053, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI27436966, Length=340, Percent_Identity=28.8235294117647, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI27436971, Length=338, Percent_Identity=28.9940828402367, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI223718702, Length=314, Percent_Identity=27.7070063694268, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI41327764, Length=289, Percent_Identity=27.681660899654, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI41152114, Length=316, Percent_Identity=25.9493670886076, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87081735, Length=341, Percent_Identity=31.9648093841642, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788070, Length=314, Percent_Identity=31.5286624203822, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789375, Length=331, Percent_Identity=29.0030211480363, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787674, Length=321, Percent_Identity=28.6604361370716, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789199, Length=357, Percent_Identity=28.2913165266106, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788081, Length=286, Percent_Identity=29.020979020979, Blast_Score=101, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17564128, Length=335, Percent_Identity=23.2835820895522, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323998, Length=328, Percent_Identity=27.4390243902439, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319958, Length=297, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6325169, Length=335, Percent_Identity=28.3582089552239, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322615, Length=252, Percent_Identity=26.984126984127, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325384, Length=343, Percent_Identity=26.530612244898, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319951, Length=342, Percent_Identity=26.0233918128655, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321052, Length=159, Percent_Identity=31.4465408805031, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640980, Length=353, Percent_Identity=24.929178470255, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45549126, Length=353, Percent_Identity=24.929178470255, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646159, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646155, Length=165, Percent_Identity=33.9393939393939, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37041; Mature: 37041

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRTLGQTGEKVSALGLGCMGMSFAYGASDDTQSIATLEKALDLGINFWDTADMYGNGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCH
NEVLLSKVLEKHRDKVFLATKFGFRYKEDNLNPKNSLESYIDGSPEWIKVAVENSLRRLN
HHHHHHHHHHHHCCCEEEEEECCCEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHC
TDVIDLYYAHRIDPNVPVEDTIGAMADLVKQGKVRYLGLSEASAETIRKAHAIHPIAAVQ
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCHHHHHH
HEYSLLTREFEQTHLQTIRELGISLVPYSPLSRGLITNTLDVNNLDENDFRRQLPRYQGD
HHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCEECCCCCCCCCHHHHHHHCCCCCCC
NWKNNQSLAQAFSEFAQSKNATAAQLALAWIFAQGDDIIPIPGTRKIERLVENAGAVDLH
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCEEECCCCHHHHHHHHCCCCEEEE
LTAADLAEIEAIIARYPNMGARYNAQQLAAVNH
EEHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MKYRTLGQTGEKVSALGLGCMGMSFAYGASDDTQSIATLEKALDLGINFWDTADMYGNGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCH
NEVLLSKVLEKHRDKVFLATKFGFRYKEDNLNPKNSLESYIDGSPEWIKVAVENSLRRLN
HHHHHHHHHHHHCCCEEEEEECCCEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHC
TDVIDLYYAHRIDPNVPVEDTIGAMADLVKQGKVRYLGLSEASAETIRKAHAIHPIAAVQ
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCHHHHHH
HEYSLLTREFEQTHLQTIRELGISLVPYSPLSRGLITNTLDVNNLDENDFRRQLPRYQGD
HHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCEECCCCCCCCCHHHHHHHCCCCCCC
NWKNNQSLAQAFSEFAQSKNATAAQLALAWIFAQGDDIIPIPGTRKIERLVENAGAVDLH
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCEEECCCCHHHHHHHHCCCCEEEE
LTAADLAEIEAIIARYPNMGARYNAQQLAAVNH
EEHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]