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The map label for this gene is mutT [C]

Identifier: 213158685

GI number: 213158685

Start: 2730668

End: 2731567

Strand: Reverse

Name: mutT [C]

Synonym: AB57_2641

Alternate gene names: 213158685

Gene position: 2731567-2730668 (Counterclockwise)

Preceding gene: 213158687

Following gene: 213158683

Centisome position: 67.44

GC content: 39.33

Gene sequence:

>900_bases
ATGCCCAAACCGATTGTCGATGTCGCAATAGCTATCTTAATTCATCGTGGAAAAATATTAGTGGGATGGCGTGGTGAACA
GCAGCATCAAGGTGGAAAGCATGAGTTTCCTGGTGGAAAGGTAGAGCAGGGTGAAACGCCTGAAGAAGCCTGCCGCCGTG
AAATTTATGAAGAAGTCGGTATTGGTTTAAAAGATTGGCATCAATTTGATTATATTCACCATGAATATGATGACATTATC
GTCAACCTTCATTTGTTCCATAGCTATGTACCTGATGAGTTATTAAATCTTATTCATCAGCCTTGGACATGGTACACACG
TGAACAGCTACTTCACCTAAACTTCCCGAAAGCTAATAAAGACATTATTAAAAGATTATATTGGCCTCATTTTATTAAAA
TTAGCCATACACTTACATCTGTAGAGAATAGTGATGCTTTATTGTATTGGCGTATAGAAGATGAATTTGGCCCGCGAGAA
GTAGAACAATTAACGGCCTTAGATGAAGGGCAACGATCAAATTTAATTATAAATGTAGATATTTGGCAGCAATTGAACCC
CGAGTTAAAAAAAAAGATCAAGACTGTTCATTTAAAACAATCTCAGCTCATGAGTTTACATAAAGGTGACTTAGAGGTAG
GAGTACGTTTTATTGCTGCTTGTCACGATGCAGTTTCTTTACAACATGCTCAGCAAATTGGCTGTGATGCCGTTTTTGTT
AGTCCTGTAAAAGTGACGGCTACTCATCCGGACGTTAGTGCATTAGGGTGGGATCGTTTTGCTGATTTAATCGAGAAGTG
CCAAATTCCCGTATTTGCTTTGGGAGGCATGAGTCCTGATGATTTAGCCACAGCACAACAACATGGTGCATATGGCTTGG
CGGGTATTCGTAATTTTTAA

Upstream 100 bases:

>100_bases
ATGATAATCATTATCGAATAGATCTGTCAACGAGATTTTAAAGATTTTATAAATTGATAAAATTTGCTTACACTTGTGAA
AAATTTTAGTGAGTAGAAAA

Downstream 100 bases:

>100_bases
TAAGAAATAAAGCATTAAAAGCTAGAAAGCTTTCAATGCTTGTTGTGCTTCTTGAACAGTTTTTGGATTATTGCGTTGTT
GCCCAGCTTTTAAAATGACC

Product: MutT/NUDIX family protein

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: Thiamine Monophosphate Synthase; NUDIX Hydrolase; Nucleoside Triphosphate Pyrophosphohydrolase; Mutator Protein MutT; A/G-Specific Adenine Glycosylase; Hydrolase NUDIX Family; 7 8-Dihydro-8-Oxoguanine-Triphosphatase; Mutator MutT; Thiamine-Phosphate Pyrophosphorylase ThiE; NTP Pyrophosphohydrolase; MutT/Nudix Family Protein; Thiamine-Phosphate Pyrophosphorylase Protein; MutT/NUDIX Family Protein; (Di)Nucleoside Polyphosphate Hydrolase; Nudix Hydrolase Protein; Pyrophosphohydrolase; DGTP-Pyrophosphohydrolase; NUDIX Domain-Containing; Mutator Protein; MutT Protein; 78-Dihydro-8-Oxoguanine-Triphosphatase Prefers DGTP; Thiamin-Phosphate Pyrophosphorylase; 8-Oxo-DGTPase; Thiamine-Phosphate Pyrophosphorylase; Thiamine Monophosphate Synthase/TENI Subfamily

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MPKPIVDVAIAILIHRGKILVGWRGEQQHQGGKHEFPGGKVEQGETPEEACRREIYEEVGIGLKDWHQFDYIHHEYDDII
VNLHLFHSYVPDELLNLIHQPWTWYTREQLLHLNFPKANKDIIKRLYWPHFIKISHTLTSVENSDALLYWRIEDEFGPRE
VEQLTALDEGQRSNLIINVDIWQQLNPELKKKIKTVHLKQSQLMSLHKGDLEVGVRFIAACHDAVSLQHAQQIGCDAVFV
SPVKVTATHPDVSALGWDRFADLIEKCQIPVFALGGMSPDDLATAQQHGAYGLAGIRNF

Sequences:

>Translated_299_residues
MPKPIVDVAIAILIHRGKILVGWRGEQQHQGGKHEFPGGKVEQGETPEEACRREIYEEVGIGLKDWHQFDYIHHEYDDII
VNLHLFHSYVPDELLNLIHQPWTWYTREQLLHLNFPKANKDIIKRLYWPHFIKISHTLTSVENSDALLYWRIEDEFGPRE
VEQLTALDEGQRSNLIINVDIWQQLNPELKKKIKTVHLKQSQLMSLHKGDLEVGVRFIAACHDAVSLQHAQQIGCDAVFV
SPVKVTATHPDVSALGWDRFADLIEKCQIPVFALGGMSPDDLATAQQHGAYGLAGIRNF
>Mature_298_residues
PKPIVDVAIAILIHRGKILVGWRGEQQHQGGKHEFPGGKVEQGETPEEACRREIYEEVGIGLKDWHQFDYIHHEYDDIIV
NLHLFHSYVPDELLNLIHQPWTWYTREQLLHLNFPKANKDIIKRLYWPHFIKISHTLTSVENSDALLYWRIEDEFGPREV
EQLTALDEGQRSNLIINVDIWQQLNPELKKKIKTVHLKQSQLMSLHKGDLEVGVRFIAACHDAVSLQHAQQIGCDAVFVS
PVKVTATHPDVSALGWDRFADLIEKCQIPVFALGGMSPDDLATAQQHGAYGLAGIRNF

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 34203; Mature: 34072

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPIVDVAIAILIHRGKILVGWRGEQQHQGGKHEFPGGKVEQGETPEEACRREIYEEVG
CCCHHHHHHHHHHHHCCEEEEEECCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
IGLKDWHQFDYIHHEYDDIIVNLHLFHSYVPDELLNLIHQPWTWYTREQLLHLNFPKANK
CCHHHHHHHHHHHHCCCHHEEEHHHHHHCCHHHHHHHHCCCCCHHCHHHEEEECCCCCCH
DIIKRLYWPHFIKISHTLTSVENSDALLYWRIEDEFGPREVEQLTALDEGQRSNLIINVD
HHHHHHHCCCEEEEEHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEE
IWQQLNPELKKKIKTVHLKQSQLMSLHKGDLEVGVRFIAACHDAVSLQHAQQIGCDAVFV
CHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SPVKVTATHPDVSALGWDRFADLIEKCQIPVFALGGMSPDDLATAQQHGAYGLAGIRNF
CCEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PKPIVDVAIAILIHRGKILVGWRGEQQHQGGKHEFPGGKVEQGETPEEACRREIYEEVG
CCHHHHHHHHHHHHCCEEEEEECCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
IGLKDWHQFDYIHHEYDDIIVNLHLFHSYVPDELLNLIHQPWTWYTREQLLHLNFPKANK
CCHHHHHHHHHHHHCCCHHEEEHHHHHHCCHHHHHHHHCCCCCHHCHHHEEEECCCCCCH
DIIKRLYWPHFIKISHTLTSVENSDALLYWRIEDEFGPREVEQLTALDEGQRSNLIINVD
HHHHHHHCCCEEEEEHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEE
IWQQLNPELKKKIKTVHLKQSQLMSLHKGDLEVGVRFIAACHDAVSLQHAQQIGCDAVFV
CHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SPVKVTATHPDVSALGWDRFADLIEKCQIPVFALGGMSPDDLATAQQHGAYGLAGIRNF
CCEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA