Click here to switch to the map view.

The map label for this gene is lpxH [H]

Identifier: 213158492

GI number: 213158492

Start: 2530812

End: 2531531

Strand: Direct

Name: lpxH [H]

Synonym: AB57_2442

Alternate gene names: 213158492

Gene position: 2530812-2531531 (Clockwise)

Preceding gene: 213158491

Following gene: 213158493

Centisome position: 62.48

GC content: 37.64

Gene sequence:

>720_bases
GTGACTTATCTGTTTATTTCAGATTTACACTTGTCACCTGAACACCCTCGACTCGTTCGAGGGTTTTTAGATTTGTTGGT
ACATTATCAAAATAAACAAACACAGCTTTATATTTTAGGTGATTGGTTTAATGCTTGGATTGGTGATGACTATTCAGCGC
CTTGGCTCGACGAAATTGTCGAGGCTTTGAAAGTATTTAACCAAAAAGGGAATCGCGTTTATTTCCAAGTGGGTAACCGA
GACTTTGCTTTAAATCAGGTTTTCCTTGATAAGTTTAATGGTGTATTACTTCCTGATATTTATTATCTCAACATTGCAGG
TCACCAATACCGTTTGGAACATGGCGATGCGTTATGTACTGATGATATTTCCTATCAAAGATTTAAAAAAATTATCCGAA
ATCCCTTCCTAGTTGCTTTTTTACGCCGCACCCCCTTGAGTTTCCGTACAAAACTGGTCAATGGTTTTCGCAAAAGAAGC
CATTCAGACAAACAGCAAAAAAGTTATGAAATTATGGATGTAAATGAACAAGCTGTTCTCTCTGCCCTCACAGATGTAGA
TATACTTATTCATGGACACACTCACCGTCCAGCAATTCATCAATTGCAACATAAACAGCGGGTTGTTCTTGGTGATTGGC
GTGAAGATCATGCACAAATTTTAGAAATTGATCCCTCTTCACATCTGCCGCAAATCAAACTAACTGATTGGTATTATTAA

Upstream 100 bases:

>100_bases
CGTACGTACAGGTAACCGTGGTTATCACGCTGACGTTCCTTTAGAAAACGTTGTTATCGAATCTGCTAAAATTATTTCTG
AATAATTTTAGGATAAAGCA

Downstream 100 bases:

>100_bases
TTAATATTCAGTTATTTTTCAAATACTTATATTTTTTTATTTAAATCAAAATCCCAAATCATACATAGACAGGTAATAAA
TACAAATTTCCAGTTTATAT

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTYLFISDLHLSPEHPRLVRGFLDLLVHYQNKQTQLYILGDWFNAWIGDDYSAPWLDEIVEALKVFNQKGNRVYFQVGNR
DFALNQVFLDKFNGVLLPDIYYLNIAGHQYRLEHGDALCTDDISYQRFKKIIRNPFLVAFLRRTPLSFRTKLVNGFRKRS
HSDKQQKSYEIMDVNEQAVLSALTDVDILIHGHTHRPAIHQLQHKQRVVLGDWREDHAQILEIDPSSHLPQIKLTDWYY

Sequences:

>Translated_239_residues
MTYLFISDLHLSPEHPRLVRGFLDLLVHYQNKQTQLYILGDWFNAWIGDDYSAPWLDEIVEALKVFNQKGNRVYFQVGNR
DFALNQVFLDKFNGVLLPDIYYLNIAGHQYRLEHGDALCTDDISYQRFKKIIRNPFLVAFLRRTPLSFRTKLVNGFRKRS
HSDKQQKSYEIMDVNEQAVLSALTDVDILIHGHTHRPAIHQLQHKQRVVLGDWREDHAQILEIDPSSHLPQIKLTDWYY
>Mature_238_residues
TYLFISDLHLSPEHPRLVRGFLDLLVHYQNKQTQLYILGDWFNAWIGDDYSAPWLDEIVEALKVFNQKGNRVYFQVGNRD
FALNQVFLDKFNGVLLPDIYYLNIAGHQYRLEHGDALCTDDISYQRFKKIIRNPFLVAFLRRTPLSFRTKLVNGFRKRSH
SDKQQKSYEIMDVNEQAVLSALTDVDILIHGHTHRPAIHQLQHKQRVVLGDWREDHAQILEIDPSSHLPQIKLTDWYY

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=226, Percent_Identity=42.0353982300885, Blast_Score=173, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 28233; Mature: 28101

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLFISDLHLSPEHPRLVRGFLDLLVHYQNKQTQLYILGDWFNAWIGDDYSAPWLDEIV
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCCCHHHHHH
EALKVFNQKGNRVYFQVGNRDFALNQVFLDKFNGVLLPDIYYLNIAGHQYRLEHGDALCT
HHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEECCCEEEEEECCCEEEECCCCEEEC
DDISYQRFKKIIRNPFLVAFLRRTPLSFRTKLVNGFRKRSHSDKQQKSYEIMDVNEQAVL
CCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCEEEEECCHHHHH
SALTDVDILIHGHTHRPAIHQLQHKQRVVLGDWREDHAQILEIDPSSHLPQIKLTDWYY
HHHCCEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCCEEEEECCCCCCCEEEECCCCC
>Mature Secondary Structure 
TYLFISDLHLSPEHPRLVRGFLDLLVHYQNKQTQLYILGDWFNAWIGDDYSAPWLDEIV
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCCCHHHHHH
EALKVFNQKGNRVYFQVGNRDFALNQVFLDKFNGVLLPDIYYLNIAGHQYRLEHGDALCT
HHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEECCCEEEEEECCCEEEECCCCEEEC
DDISYQRFKKIIRNPFLVAFLRRTPLSFRTKLVNGFRKRSHSDKQQKSYEIMDVNEQAVL
CCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCEEEEECCHHHHH
SALTDVDILIHGHTHRPAIHQLQHKQRVVLGDWREDHAQILEIDPSSHLPQIKLTDWYY
HHHCCEEEEEECCCCCHHHHHHHHHCCEEECCCCCCCCEEEEECCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA