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The map label for this gene is cyp18 [H]

Identifier: 213158491

GI number: 213158491

Start: 2530287

End: 2530796

Strand: Direct

Name: cyp18 [H]

Synonym: AB57_2441

Alternate gene names: 213158491

Gene position: 2530287-2530796 (Clockwise)

Preceding gene: 213158489

Following gene: 213158492

Centisome position: 62.47

GC content: 41.18

Gene sequence:

>510_bases
ATGAGTTTTCCTCAAGTCGAATTAAACACCAACAAAGGTCGTATTGTTCTTGAGCTTAACACTGAAAAAGCACCGAAAAC
GGCTGCTAATTTTCTAGAATACGTACGTGACGGTTTCTATGATGGCGTGATTTTCCACCGCGTTATCGACGGTTTCATGA
TCCAAGGTGGTGGCTTTGACGAAAACTTCAAAGAAAAAGCAACTCGTGATGCGATTGAAAATGAAGCTGACAACGGTTTA
AGCAACGATGTAGGTACCATTGCAATGGCACGTACTCAAGCTCCGCACTCTGCTTCTGCACAATTCTTCATCAACGTAAA
AAACAACTCTTTCCTGAACCATACTTCAAAAACTGCACAAGGTTGGGGTTATGCTGTATTCGGTAAAGTTGTTGAAGGTA
TGGACGTTGTAGAAGCAATCAAAGGCGTACGTACAGGTAACCGTGGTTATCACGCTGACGTTCCTTTAGAAAACGTTGTT
ATCGAATCTGCTAAAATTATTTCTGAATAA

Upstream 100 bases:

>100_bases
ATTTTAACGTTTTTTACTTGCCTTGTAGTTTACAGTTTGCTTATGCTTCTCTCAACCAAAAACCCATGGTCAATTTGCCC
ATGTTTAGGAGATTAATGTA

Downstream 100 bases:

>100_bases
TTTTAGGATAAAGCAGTGACTTATCTGTTTATTTCAGATTTACACTTGTCACCTGAACACCCTCGACTCGTTCGAGGGTT
TTTAGATTTGTTGGTACATT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSFPQVELNTNKGRIVLELNTEKAPKTAANFLEYVRDGFYDGVIFHRVIDGFMIQGGGFDENFKEKATRDAIENEADNGL
SNDVGTIAMARTQAPHSASAQFFINVKNNSFLNHTSKTAQGWGYAVFGKVVEGMDVVEAIKGVRTGNRGYHADVPLENVV
IESAKIISE

Sequences:

>Translated_169_residues
MSFPQVELNTNKGRIVLELNTEKAPKTAANFLEYVRDGFYDGVIFHRVIDGFMIQGGGFDENFKEKATRDAIENEADNGL
SNDVGTIAMARTQAPHSASAQFFINVKNNSFLNHTSKTAQGWGYAVFGKVVEGMDVVEAIKGVRTGNRGYHADVPLENVV
IESAKIISE
>Mature_168_residues
SFPQVELNTNKGRIVLELNTEKAPKTAANFLEYVRDGFYDGVIFHRVIDGFMIQGGGFDENFKEKATRDAIENEADNGLS
NDVGTIAMARTQAPHSASAQFFINVKNNSFLNHTSKTAQGWGYAVFGKVVEGMDVVEAIKGVRTGNRGYHADVPLENVVI
ESAKIISE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=33.1325301204819, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547215, Length=168, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI22547212, Length=168, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=168, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI19557636, Length=169, Percent_Identity=31.3609467455621, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=33.1210191082803, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI10863927, Length=156, Percent_Identity=35.8974358974359, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI310110104, Length=142, Percent_Identity=37.3239436619718, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310129267, Length=156, Percent_Identity=35.2564102564103, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310120620, Length=156, Percent_Identity=35.2564102564103, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=61.4906832298137, Blast_Score=212, Evalue=1e-56,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=54.2682926829268, Blast_Score=174, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.2465753424658, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=34.0136054421769, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=31.547619047619, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=149, Percent_Identity=35.5704697986577, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=35.4430379746835, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=176, Percent_Identity=30.1136363636364, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=32.3170731707317, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=174, Percent_Identity=30.4597701149425, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=176, Percent_Identity=32.3863636363636, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=176, Percent_Identity=32.9545454545455, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=163, Percent_Identity=35.5828220858896, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19922376, Length=176, Percent_Identity=27.8409090909091, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=33.1325301204819, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664125, Length=166, Percent_Identity=34.3373493975904, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357783, Length=166, Percent_Identity=34.3373493975904, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45549139, Length=149, Percent_Identity=36.241610738255, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922912, Length=167, Percent_Identity=31.1377245508982, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136360, Length=170, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18545; Mature: 18414

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPQVELNTNKGRIVLELNTEKAPKTAANFLEYVRDGFYDGVIFHRVIDGFMIQGGGFD
CCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCC
ENFKEKATRDAIENEADNGLSNDVGTIAMARTQAPHSASAQFFINVKNNSFLNHTSKTAQ
CHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCC
GWGYAVFGKVVEGMDVVEAIKGVRTGNRGYHADVPLENVVIESAKIISE
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFPQVELNTNKGRIVLELNTEKAPKTAANFLEYVRDGFYDGVIFHRVIDGFMIQGGGFD
CCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCC
ENFKEKATRDAIENEADNGLSNDVGTIAMARTQAPHSASAQFFINVKNNSFLNHTSKTAQ
CHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCC
GWGYAVFGKVVEGMDVVEAIKGVRTGNRGYHADVPLENVVIESAKIISE
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]