Click here to switch to the map view.

The map label for this gene is ampC [C]

Identifier: 213158431

GI number: 213158431

Start: 2466656

End: 2467915

Strand: Reverse

Name: ampC [C]

Synonym: AB57_2380

Alternate gene names: 213158431

Gene position: 2467915-2466656 (Counterclockwise)

Preceding gene: 213158432

Following gene: 213158429

Centisome position: 60.93

GC content: 41.98

Gene sequence:

>1260_bases
GTGATTAAAGAAATTTTACTGGCCGATACCCATAACTATCACGGTATTTTAGATGAACGTTTTATTGATTTAGCTCACCA
GTTCAGCCGTCTTCAAGATGCTAGAACAGGACAAGGTGGAGCTGCTTTAGCGGTTTATTTTAGAGGCCAAAAAGTTGTAG
ATATCTACACCGGTCTAAAATCACAAACTGAAGCTTGGCAACCTGACACATTGGCAGTTTGCTACTCTACAGGTAAGGGT
GTACTTGCAACTTTAGCGCATATTTTGGTAAGTGAAGGGTTTTTAGAATACGACAAACCGATTGCGACCTATTGGCCTGA
GTTTGCTCAAAATGGAAAAGAGCAAATGACTTTGCGTCATGTGCTAAGCCATCAAAGCGGCATGTTTGATGTTCGAAATA
TCATCGAAAGTGCGAGAGAAATGCTCGACTGGTCACATATGTTAGATGTGGTCGCGGCGACTAAGCCAAGATTCCTTGCA
GGAGAGGGCAATGCTTATCAAGCTTTAACATTCGGTTGGCTTGTCGGTGGCGTACTTGAAAAAGCAACTGGTCAATCTCT
AGATCAGCTCATGCAAAAATATCTTGTTGAGCCATTACAGTTAGATGGTGCTTATTTTGGAACGCCTGCAAATGAGTTGG
ATCGTGTAGCACGTTTAATTATTCAACCAAAACCAGAAAAACCAGCATCTACTCAAGTTGAAAAACCTAAAAAGCCACAG
ACGCGTAAGAGTTCACTCTCTGAAAAAATGATTACATGGACGGGTCAAGACCCGCAAGATTTTCAGGATGCCATGATTCC
AAAAGGAATGAAAAATTTTAGTTTCTTTAGCGATGAGGGATTGCAAGCAGTCATTCCGGCAGCGAACGGAACATTTACTG
CAAATAGCCTGGCTAAAATTTATGCGATGCTAGCAAATCAAGGTGAATGGGATGGACAGCAATTGATTCGCCCAGAAATA
TTTAAAGAACTTAGTACTATTCAAAGTTATGCACGTGATCGTGTCATGCCAATACCGATGAATTGGCGCTTAGGATATCA
CCGCATTATTACTATGGGTAAACGTGCAAAAAATGGCTTTGGGCATATTGGTTACAATGGTTCAGGAGCGTGGTGTGATC
CTGAGCGTGACCTCAGCTTTGCTTATACTCATAACTTCCAGATTGGTTCAATCACAGGCGATTATCGTTTGTGGGGGCTG
ACCCAAGAAGCTTTACGTTGCACAGACCAAATTTTAAAAGGCCGTAAAGGCTGGTTCTAA

Upstream 100 bases:

>100_bases
ATGTTGCAGGAACTGTAAAAGCATTATAAAAATAGCAGCAGCCTGAACAGAGGTTTGGGCTGCTTTTGAGCAAAATAACA
AAAAATGCAAGGAACTTCAT

Downstream 100 bases:

>100_bases
TTTTAGTATTTTAAAGCTGGTATTTTTAAGCAATGCCAGCTCAACATTTATAATAATTCTAGGCGAATAATTGCTTCGGT
ATGACGCTTAAAATCTTCTT

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Beta-Lactamase Class C; Esterase/Lipase LipP; Esterase A; Esterase/Lipase/Beta-Lactamase; Lactone Hydrolase; Lipase LipE; Beta-Lactamase Protein; Esterase LipL; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-Lactamase Family Protein; Beta-Lactamase-Like Protein; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MIKEILLADTHNYHGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLKSQTEAWQPDTLAVCYSTGKG
VLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRHVLSHQSGMFDVRNIIESAREMLDWSHMLDVVAATKPRFLA
GEGNAYQALTFGWLVGGVLEKATGQSLDQLMQKYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQ
TRKSSLSEKMITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKIYAMLANQGEWDGQQLIRPEI
FKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGL
TQEALRCTDQILKGRKGWF

Sequences:

>Translated_419_residues
MIKEILLADTHNYHGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLKSQTEAWQPDTLAVCYSTGKG
VLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRHVLSHQSGMFDVRNIIESAREMLDWSHMLDVVAATKPRFLA
GEGNAYQALTFGWLVGGVLEKATGQSLDQLMQKYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQ
TRKSSLSEKMITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKIYAMLANQGEWDGQQLIRPEI
FKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGL
TQEALRCTDQILKGRKGWF
>Mature_419_residues
MIKEILLADTHNYHGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLKSQTEAWQPDTLAVCYSTGKG
VLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRHVLSHQSGMFDVRNIIESAREMLDWSHMLDVVAATKPRFLA
GEGNAYQALTFGWLVGGVLEKATGQSLDQLMQKYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQ
TRKSSLSEKMITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKIYAMLANQGEWDGQQLIRPEI
FKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGL
TQEALRCTDQILKGRKGWF

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI71983659, Length=394, Percent_Identity=27.1573604060914, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17538001, Length=392, Percent_Identity=28.0612244897959, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983666, Length=311, Percent_Identity=26.3665594855305, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17538474, Length=419, Percent_Identity=26.2529832935561, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17535191, Length=409, Percent_Identity=26.8948655256724, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17535177, Length=384, Percent_Identity=24.7395833333333, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71990590, Length=362, Percent_Identity=21.2707182320442, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 47127; Mature: 47127

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEILLADTHNYHGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLK
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEHHHCCC
SQTEAWQPDTLAVCYSTGKGVLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRH
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHCCCHHHCCHHHHHCCHHHHHHHH
VLSHQSGMFDVRNIIESAREMLDWSHMLDVVAATKPRFLAGEGNAYQALTFGWLVGGVLE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
KATGQSLDQLMQKYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQ
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TRKSSLSEKMITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKI
HHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
YAMLANQGEWDGQQLIRPEIFKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCC
GHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLTQEALRCTDQILKGRKGWF
CCCCCCCCCCCCCCCCCCEEEEEECEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKEILLADTHNYHGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLK
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEHHHCCC
SQTEAWQPDTLAVCYSTGKGVLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRH
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHCCCHHHCCHHHHHCCHHHHHHHH
VLSHQSGMFDVRNIIESAREMLDWSHMLDVVAATKPRFLAGEGNAYQALTFGWLVGGVLE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
KATGQSLDQLMQKYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQ
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TRKSSLSEKMITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKI
HHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
YAMLANQGEWDGQQLIRPEIFKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCC
GHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLTQEALRCTDQILKGRKGWF
CCCCCCCCCCCCCCCCCCEEEEEECEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA