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The map label for this gene is smvA [H]

Identifier: 213158429

GI number: 213158429

Start: 2464426

End: 2465904

Strand: Reverse

Name: smvA [H]

Synonym: AB57_2378

Alternate gene names: 213158429

Gene position: 2465904-2464426 (Counterclockwise)

Preceding gene: 213158431

Following gene: 213158428

Centisome position: 60.88

GC content: 40.03

Gene sequence:

>1479_bases
ATGCAAAAAAAATGGTTAATCCTGACAATTATCGTCCTCATTTATTTACCAGTTACGATTGATGCAACGGTGATGCATGT
TGCAACACCATCTTTAAGTGCAGCATTGAATTTAACTGCCAATCAGCTTTTATGGATTATTGATATTTATTCGCTGATTA
TGGCGGGTTTGATTTTGCCGATGGGTGCACTCGGTGATCGTATTGGCTTTAAAAAATTATTATTTATTGGAACCGCAGTT
TTTGGTGTGGGTTCGTTAGCTGCGGCTTTTTCTCCAACTGCCTATGCCTTAATTGCTTCTCGTGCTATTTTAGGCCTAGG
GGCAGCTATGCTTATTCCTGCCACTTTATCCGGTATCCGTAATGCTTTTACCGAAGAAAAGCAGAGAAATTTTGCACTTG
GTATTTGGTCTACAGTAGGTGGAGGTGGAGCAGCTTTTGGTCCATTAGTCGGTGGTTTTGTATTAGAACACTTCCATTGG
GGAGCTGTATTCCTCATTAATATCCCGATTATTTTAGCCGTTCTAGTTATGATCGTGATGATCATTCCTAAACAACAAGA
GAAAACTGATCAGCCAATTAACTTAGGGCAAGCTTTAGTTTTGGTTGTAGCAATTTTAAGCCTCATCTATTCAATTAAAT
CGGCTATGTATAACTTTTCGGTGCTCACGGTTGTGATGTTTGTGGTGGGTATAAGCACATTAATTCACTTCATTCGAAGC
CAAAAAAGAGCTACGACACCAATGATTGATCTGGAGTTATTTAAACATCCAGTAATTTCTACAAGTATTGTTATGGCTGT
TGTTTCCATGATTGCTTTGGTTGGCTTTGAATTATTACTGTCTCAAGAGTTGCAGTTTGTACACGGGTTTTCTCCATTAC
AGGCGGCGATGTTTATTATTCCATTTATGATTGCAATTAGTTTAGGTGGTCCATTAGCAGGTATTTGTTTAAATAAATGG
GGTTTACGTAGAGTATCGAGCCTAGGTATTTTAGTGAGCGCGCTCAGTTTATGGGGGCTTGCTCAGCTTAATTTTTCAAC
CGACCACTTTTTAGCATGGACATGTATGGTCTTTTTGGGCTTTAGCATTGAGATTGCCTTACTTGCCTCAACTGCTGCCA
TTATGTCATCTGTGCCCCCTCAAAAGGCGAGTGCAGCAGGTGCTATTGAGGGAATGGCCTATGAGCTTGGCGCTGGCTTA
GGTGTTGCTATTTTTGGTTTAATGTTGTCTTGGTTTTATAGCCGCTCAATTATTTTGCCAGCCGAGCTTCCGTCAAACTT
AATTGAAAAAGCGAGTATCTCGATTGGAGAAACCATGCAATTAGCCTCTAATCTTGAAAATCCTTTAGGAGGGCAATTAA
TTGTAGTGGCGCAGCAAGCTTTTAGCTATGCCCATAGTTGGGTACTTACCCTCTCAGCGATCTGTTTCTTCCTTTTAACT
GTATTTGTCTGGTTTAGTTTTCCGAAGAAAGTAAATTAA

Upstream 100 bases:

>100_bases
CACAAACTACAATAAAATTTAAAGTTGGACAAGTGTCCAGTTGTGTATATAATAACCGCAATTTGAACACATGTCCAAGT
TTTGGATATCGAAGAGCGTT

Downstream 100 bases:

>100_bases
TATTTTTCACAGTATTTAAAGTTTCGGTAGAGAACCTTTTCTTCGAAACTTTAAAATTCACTGATAGTCCAGACAAATGA
TGTAGTTCGCAGTTTATCTG

Product: methyl viologen resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILPMGALGDRIGFKKLLFIGTAV
FGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIRNAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHW
GAVFLINIPIILAVLVMIVMIIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRS
QKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFIIPFMIAISLGGPLAGICLNKW
GLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLGFSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGL
GVAIFGLMLSWFYSRSIILPAELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLT
VFVWFSFPKKVN

Sequences:

>Translated_492_residues
MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILPMGALGDRIGFKKLLFIGTAV
FGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIRNAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHW
GAVFLINIPIILAVLVMIVMIIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRS
QKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFIIPFMIAISLGGPLAGICLNKW
GLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLGFSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGL
GVAIFGLMLSWFYSRSIILPAELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLT
VFVWFSFPKKVN
>Mature_492_residues
MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILPMGALGDRIGFKKLLFIGTAV
FGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIRNAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHW
GAVFLINIPIILAVLVMIVMIIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRS
QKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFIIPFMIAISLGGPLAGICLNKW
GLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLGFSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGL
GVAIFGLMLSWFYSRSIILPAELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLT
VFVWFSFPKKVN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=479, Percent_Identity=26.7223382045929, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081983, Length=418, Percent_Identity=27.2727272727273, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789042, Length=489, Percent_Identity=26.3803680981595, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790195, Length=398, Percent_Identity=27.1356783919598, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788392, Length=411, Percent_Identity=26.7639902676399, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52806; Mature: 52806

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILP
CCCCHHHHHHHHHHHHHHHHCHHHHEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MGALGDRIGFKKLLFIGTAVFGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHWGAVFLINIPIILAVLVMIVM
HHHHHHHHCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRS
HCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFII
HHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
PFMIAISLGGPLAGICLNKWGLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHC
FSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGLGVAIFGLMLSWFYSRSIILP
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEC
AELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLT
HHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VFVWFSFPKKVN
HHHHHCCCCCCC
>Mature Secondary Structure
MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILP
CCCCHHHHHHHHHHHHHHHHCHHHHEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MGALGDRIGFKKLLFIGTAVFGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHWGAVFLINIPIILAVLVMIVM
HHHHHHHHCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRS
HCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFII
HHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
PFMIAISLGGPLAGICLNKWGLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHC
FSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGLGVAIFGLMLSWFYSRSIILP
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEC
AELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLT
HHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VFVWFSFPKKVN
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7926834; 11677609 [H]