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The map label for this gene is wzb [C]

Identifier: 213158423

GI number: 213158423

Start: 2455726

End: 2456229

Strand: Reverse

Name: wzb [C]

Synonym: AB57_2372

Alternate gene names: 213158423

Gene position: 2456229-2455726 (Counterclockwise)

Preceding gene: 213158424

Following gene: 213158422

Centisome position: 60.64

GC content: 38.69

Gene sequence:

>504_bases
ATGGAAGCACAGTATAAGGTGTTATGTGTCTGTTTAGGAAATATTTGCCGTTCTCCCACGGCTGAAGTGGTTTTTAGACA
TTATTGTGATCAGCATCAACTCAATATCATTGTCGATTCAGCTGGAACAAGTAACTATCATCCAAATAAAGCACCTGATC
AGCGTAGCCAATTGCATGCAAAAAAAAGAGGTTATGACTTATCTTCTTTGCGGGCAAGACAACTTTCAACTCAAGACTTT
TTAGATTTTGATTTGATTTTGGCAATGGATCATCAAAACTTTGATGATATCCACGATTTGCTACAAAGAGCTATCTTCCA
ATTTGGCAGCCATCAAATTCGGGCAAAAGTGGCATTAATGAGTGAACATGATCCTCAATATCCACAACAAGCTCTGCCTG
ACCCTTACTATGGTGGAGATGAGGGCTTTGAACGTGTACTCGACCAATGTGAATCAAGTGCGTTGGCGTGGATTAATATC
CTAAAAAAACAATTGAATGTTTAA

Upstream 100 bases:

>100_bases
CAAACCTGATAATAATGGATAATTTTGTCGGGTTTTTGCAGATTTTTGCGTGTAAAATACTTATTTATTTTTTAGTTTAA
GTGGTTGGAATAAATTTCTA

Downstream 100 bases:

>100_bases
GAACAGGTTTTTCAATACAATGCAAATTCAAAATCAAGTACAGCTTAAGCCATTCAATACTTTAAGTTTAGATGTTACAG
CTTCTCATTACACTAAGGTC

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MEAQYKVLCVCLGNICRSPTAEVVFRHYCDQHQLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDF
LDFDLILAMDHQNFDDIHDLLQRAIFQFGSHQIRAKVALMSEHDPQYPQQALPDPYYGGDEGFERVLDQCESSALAWINI
LKKQLNV

Sequences:

>Translated_167_residues
MEAQYKVLCVCLGNICRSPTAEVVFRHYCDQHQLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDF
LDFDLILAMDHQNFDDIHDLLQRAIFQFGSHQIRAKVALMSEHDPQYPQQALPDPYYGGDEGFERVLDQCESSALAWINI
LKKQLNV
>Mature_167_residues
MEAQYKVLCVCLGNICRSPTAEVVFRHYCDQHQLNIIVDSAGTSNYHPNKAPDQRSQLHAKKRGYDLSSLRARQLSTQDF
LDFDLILAMDHQNFDDIHDLLQRAIFQFGSHQIRAKVALMSEHDPQYPQQALPDPYYGGDEGFERVLDQCESSALAWINI
LKKQLNV

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=159, Percent_Identity=42.7672955974843, Blast_Score=109, Evalue=9e-25,
Organism=Homo sapiens, GI6005988, Length=159, Percent_Identity=38.3647798742138, Blast_Score=103, Evalue=8e-23,
Organism=Escherichia coli, GI1788375, Length=158, Percent_Identity=30.379746835443, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=148, Percent_Identity=33.7837837837838, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706766, Length=156, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706768, Length=156, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78711846, Length=152, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78706770, Length=160, Percent_Identity=33.75, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78706772, Length=160, Percent_Identity=33.75, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78706764, Length=133, Percent_Identity=33.0827067669173, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 19149; Mature: 19149

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAQYKVLCVCLGNICRSPTAEVVFRHYCDQHQLNIIVDSAGTSNYHPNKAPDQRSQLHA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
KKRGYDLSSLRARQLSTQDFLDFDLILAMDHQNFDDIHDLLQRAIFQFGSHQIRAKVALM
HHCCCCHHHHHHHHCCHHHHHCHHEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
SEHDPQYPQQALPDPYYGGDEGFERVLDQCESSALAWINILKKQLNV
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEAQYKVLCVCLGNICRSPTAEVVFRHYCDQHQLNIIVDSAGTSNYHPNKAPDQRSQLHA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
KKRGYDLSSLRARQLSTQDFLDFDLILAMDHQNFDDIHDLLQRAIFQFGSHQIRAKVALM
HHCCCCHHHHHHHHCCHHHHHCHHEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
SEHDPQYPQQALPDPYYGGDEGFERVLDQCESSALAWINILKKQLNV
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]