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The map label for this gene is moaA [H]

Identifier: 213158400

GI number: 213158400

Start: 2426959

End: 2427990

Strand: Reverse

Name: moaA [H]

Synonym: AB57_2348

Alternate gene names: 213158400

Gene position: 2427990-2426959 (Counterclockwise)

Preceding gene: 213158401

Following gene: 213158399

Centisome position: 59.94

GC content: 38.76

Gene sequence:

>1032_bases
ATGAAACAATATCACTCTGAAACTGCGCCAATGCTTTTGCAAGATCAATATGGGCGCATCAAGCGAAAGTTACGTATTTC
AGTAACTGATCGCTGTAATTTTAAGTGTGTGTATTGCATGCCTGAACATCCTGAATGGCTAAATAAACAAGATTTGCTTA
GTTTTGAAGCGCTCTTTCAGTTTTGCAGTTTTATGGTGCAACAAGGTATTGAAAGCATCCGTATTACGGGTGGTGAACCA
TTAATGCGTCAAGGTATTGTTCATTTCGTTCGCGATTTACAAGCTTTAAAAGCATTAGGTTTAAAGCGTATTTCAATGAC
CACTAATGGACATTATCTTGCAAAATACGCTCAGCAATTAAAAGATGCTGGTCTAGATGATTTAAATATTAGTCTAGATA
GCCTAGATCCGATTCAATTTAAAGAGCTCACTAAGAAAAAGTTAGAACCAGTTCTTGAGGGTATTCAAGCTGCAAAAGAT
GCAGGGTTACCTTTTAAAATTAACTGCGTGTTAATGAAAGATAAAAATGACGATCAAATCTTACCTATGGTGAAATGGTC
AATCGCCAATCATTTTCCGCTACGTTTTATTGAATTCATGCCGCTTGATGGTGATGCCCTTTGGTCAAATAGAGATGTGG
TGAGTGAAGCTGAAATTTTACAGGCGTTGCAACCGTATTATTCGGTACAAGTCATCGAGCAACAACATGAGCCAGCGCGT
CAATATCTACTTAATGATAGCTACACTCTAGGCATCATTTCGACCATTACTCATTCATTTTGCCACCAATGTGACCGCAT
ACGACTAACGGCACAAGGTGAGCTATATAACTGTCTATTTGCGCAGCAGGGTTTAAATATTAAGCCGCAGCTTCAAGCAT
TATTACGCGCACATAACTCAACCGATCATGTTCTGCATAGTCAGCAATTAAAAGATCAAGTTATGCCGTATATCTGGCAC
AAAGCAAAAGGCTTTCATGCCTTACAACATCAACAAACCCGTAAAATCAGTATGCATATGCTTGGGGGATAA

Upstream 100 bases:

>100_bases
CAATAAAGATCAAAGCACTACTAAGGCGCAATTTTAAAAGTTTAATTGCTCATAATCAGTGCTTGCAATATTTGAACTGT
TCTCGATATGAGTGCAAATA

Downstream 100 bases:

>100_bases
ATGCAGCAATCTATCCAAATTAAAATCGAATCATTCGGTGCAATTGAAAAATTGCTTCCCCAAAATCTTTCGATCGTTTG
TCCTGCCAATATTCTAGTGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKQYHSETAPMLLQDQYGRIKRKLRISVTDRCNFKCVYCMPEHPEWLNKQDLLSFEALFQFCSFMVQQGIESIRITGGEP
LMRQGIVHFVRDLQALKALGLKRISMTTNGHYLAKYAQQLKDAGLDDLNISLDSLDPIQFKELTKKKLEPVLEGIQAAKD
AGLPFKINCVLMKDKNDDQILPMVKWSIANHFPLRFIEFMPLDGDALWSNRDVVSEAEILQALQPYYSVQVIEQQHEPAR
QYLLNDSYTLGIISTITHSFCHQCDRIRLTAQGELYNCLFAQQGLNIKPQLQALLRAHNSTDHVLHSQQLKDQVMPYIWH
KAKGFHALQHQQTRKISMHMLGG

Sequences:

>Translated_343_residues
MKQYHSETAPMLLQDQYGRIKRKLRISVTDRCNFKCVYCMPEHPEWLNKQDLLSFEALFQFCSFMVQQGIESIRITGGEP
LMRQGIVHFVRDLQALKALGLKRISMTTNGHYLAKYAQQLKDAGLDDLNISLDSLDPIQFKELTKKKLEPVLEGIQAAKD
AGLPFKINCVLMKDKNDDQILPMVKWSIANHFPLRFIEFMPLDGDALWSNRDVVSEAEILQALQPYYSVQVIEQQHEPAR
QYLLNDSYTLGIISTITHSFCHQCDRIRLTAQGELYNCLFAQQGLNIKPQLQALLRAHNSTDHVLHSQQLKDQVMPYIWH
KAKGFHALQHQQTRKISMHMLGG
>Mature_343_residues
MKQYHSETAPMLLQDQYGRIKRKLRISVTDRCNFKCVYCMPEHPEWLNKQDLLSFEALFQFCSFMVQQGIESIRITGGEP
LMRQGIVHFVRDLQALKALGLKRISMTTNGHYLAKYAQQLKDAGLDDLNISLDSLDPIQFKELTKKKLEPVLEGIQAAKD
AGLPFKINCVLMKDKNDDQILPMVKWSIANHFPLRFIEFMPLDGDALWSNRDVVSEAEILQALQPYYSVQVIEQQHEPAR
QYLLNDSYTLGIISTITHSFCHQCDRIRLTAQGELYNCLFAQQGLNIKPQLQALLRAHNSTDHVLHSQQLKDQVMPYIWH
KAKGFHALQHQQTRKISMHMLGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=295, Percent_Identity=36.9491525423729, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI22027536, Length=295, Percent_Identity=36.9491525423729, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1786999, Length=286, Percent_Identity=31.8181818181818, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32566331, Length=295, Percent_Identity=31.864406779661, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=348, Percent_Identity=30.7471264367816, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17561210, Length=284, Percent_Identity=32.0422535211268, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI28574488, Length=351, Percent_Identity=34.1880341880342, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28574490, Length=328, Percent_Identity=34.7560975609756, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39533; Mature: 39533

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQYHSETAPMLLQDQYGRIKRKLRISVTDRCNFKCVYCMPEHPEWLNKQDLLSFEALFQ
CCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
FCSFMVQQGIESIRITGGEPLMRQGIVHFVRDLQALKALGLKRISMTTNGHYLAKYAQQL
HHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHH
KDAGLDDLNISLDSLDPIQFKELTKKKLEPVLEGIQAAKDAGLPFKINCVLMKDKNDDQI
HHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCE
LPMVKWSIANHFPLRFIEFMPLDGDALWSNRDVVSEAEILQALQPYYSVQVIEQQHEPAR
EHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYLLNDSYTLGIISTITHSFCHQCDRIRLTAQGELYNCLFAQQGLNIKPQLQALLRAHNS
HHHCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCC
TDHVLHSQQLKDQVMPYIWHKAKGFHALQHQQTRKISMHMLGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKQYHSETAPMLLQDQYGRIKRKLRISVTDRCNFKCVYCMPEHPEWLNKQDLLSFEALFQ
CCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
FCSFMVQQGIESIRITGGEPLMRQGIVHFVRDLQALKALGLKRISMTTNGHYLAKYAQQL
HHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHH
KDAGLDDLNISLDSLDPIQFKELTKKKLEPVLEGIQAAKDAGLPFKINCVLMKDKNDDQI
HHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCE
LPMVKWSIANHFPLRFIEFMPLDGDALWSNRDVVSEAEILQALQPYYSVQVIEQQHEPAR
EHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYLLNDSYTLGIISTITHSFCHQCDRIRLTAQGELYNCLFAQQGLNIKPQLQALLRAHNS
HHHCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCC
TDHVLHSQQLKDQVMPYIWHKAKGFHALQHQQTRKISMHMLGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]