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The map label for this gene is cycA [H]

Identifier: 213158319

GI number: 213158319

Start: 3140219

End: 3141625

Strand: Reverse

Name: cycA [H]

Synonym: AB57_3046

Alternate gene names: 213158319

Gene position: 3141625-3140219 (Counterclockwise)

Preceding gene: 213158322

Following gene: 213158318

Centisome position: 77.56

GC content: 40.37

Gene sequence:

>1407_bases
ATGTCGAATCAAAATCTGAGCGACCCTCATGAACAAGGTGAGCTCCATCGTAGTCTCTCTAATCGGCATTTACAGCTGAT
CGCGATTGGTGGTGCCATCGGTACCGGATTATTTATGGGTTCAGGTAAAACAATTAGTCTTGCCGGACCTTCTATCTTAT
TTATTTATATGATTATTGGTTTGATGGTGTTTTTTGTCATGCGTGCGCTTGGCGAACTTCTTCTGTCAAATTTAACCTAT
AAATCATTTATTGATTTTTCTACCGATTTAATTGGCCCATGGGCTGGTTACTTCGTGGGTTGGACCTACTGGTTGTGTTG
GATCACGATTGGTATCGCCGATCTGTCTGCAATTATTTATTACTTACAGTTCTTCAATAATGGCTTACCTTTCTCGCCTG
TTGAAGGCGCAATGATTAGTGTTGCCGCGATTGTGTTCATTATGGGATTGAACTTATTAACAGTTCGATTGTTTGGTGAA
TTAGAGTTCTGGTTTGCACTTATTAAAATCCTTGCGATTATTATTTTAATTGCAGTGGGTCTGTGGATGATCTTTACAGG
CTTTACGTCTACTACAGGTGAAGTCGCTTCATTTACTCATCTTTGGGCAAATGGCGGTTTCTTCCCAACAGGTGTGCATG
GCTTCTTGGCTGGTTTCCAGATTGCAATTTTTGCTTTCGTGGGTGTTGAACTTGTGGGAACAACAGCCGCGGAAACTAAA
GACCCTGAGCGTAATTTGCCTAAAGCGATTAACTCAATTCCAATCCGTATCATTATTTTCTATGTATTGGCGCTACTCAT
TGTAATGTCAGTAACACCATGGAACAGAATTGATCCGGCGATCAGTCCATTTGTAAACCTGTTTAGTCAAGCAGGGGTAG
CGGCAGCCGCGATTTTGATGAACTTGGTGGTATTGTCATCAGTCATGTCATCCATGAACAGTGGTGTATTCTCAACAAGT
CGTATGTTGTTTGGCTTATCTCGTGAAGATCAGGGGCCAAAAGCTTTTGGTAAGCTTAACAGACGTGCAGTACCGGCAAA
TGCATTGTATTTCTCTGCTGCGTGTTTATTGTTAGGTGCAGCATTACAGTATTTTGTACCAAATACAGTTGAAGCATTTA
CGCTTGCAACAACACTTTCAACGATTCTCTTCATCTGCGTATGGTTGCTTATTATCTGGAGTTACATCCGTTATTACACC
ACGCGTCCTGAACTGCATGCCAAATCAACATTTAAATTGCCAGGTGGCTTATTTACATGTTGGATCACGATTATTTTCTT
TATTGGTATGATTTACGTATTGTCTTTAGAGCCAGACACCTTTAAAGCGCTTAAAGTCAGCCCAATTTGGTTTGTTATTT
TGATCATTGGTTATTTCTTCTTCTATAAACCACGTCATAAAAAATAA

Upstream 100 bases:

>100_bases
AAATATACATTTAAAAGATACCTGCAAATGGTGCGATATCGTCTTTTTGATTTGATTTTAGCTAACGGACTAAAAAAATT
AACTGGAGTGTATTCATAAA

Downstream 100 bases:

>100_bases
TTAAATTTATTTGGTTATGATCAAACGCTGGCTGAAAAGCTGGCGTTTTTTATGCATATTGTTTTTCTATTCAAGTTTAC
TCTTTAGCCGCTTGCCTGAT

Product: D-serine/D-alanine/glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSNQNLSDPHEQGELHRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYMIIGLMVFFVMRALGELLLSNLTY
KSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGLPFSPVEGAMISVAAIVFIMGLNLLTVRLFGE
LEFWFALIKILAIIILIAVGLWMIFTGFTSTTGEVASFTHLWANGGFFPTGVHGFLAGFQIAIFAFVGVELVGTTAAETK
DPERNLPKAINSIPIRIIIFYVLALLIVMSVTPWNRIDPAISPFVNLFSQAGVAAAAILMNLVVLSSVMSSMNSGVFSTS
RMLFGLSREDQGPKAFGKLNRRAVPANALYFSAACLLLGAALQYFVPNTVEAFTLATTLSTILFICVWLLIIWSYIRYYT
TRPELHAKSTFKLPGGLFTCWITIIFFIGMIYVLSLEPDTFKALKVSPIWFVILIIGYFFFYKPRHKK

Sequences:

>Translated_468_residues
MSNQNLSDPHEQGELHRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYMIIGLMVFFVMRALGELLLSNLTY
KSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGLPFSPVEGAMISVAAIVFIMGLNLLTVRLFGE
LEFWFALIKILAIIILIAVGLWMIFTGFTSTTGEVASFTHLWANGGFFPTGVHGFLAGFQIAIFAFVGVELVGTTAAETK
DPERNLPKAINSIPIRIIIFYVLALLIVMSVTPWNRIDPAISPFVNLFSQAGVAAAAILMNLVVLSSVMSSMNSGVFSTS
RMLFGLSREDQGPKAFGKLNRRAVPANALYFSAACLLLGAALQYFVPNTVEAFTLATTLSTILFICVWLLIIWSYIRYYT
TRPELHAKSTFKLPGGLFTCWITIIFFIGMIYVLSLEPDTFKALKVSPIWFVILIIGYFFFYKPRHKK
>Mature_467_residues
SNQNLSDPHEQGELHRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYMIIGLMVFFVMRALGELLLSNLTYK
SFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGLPFSPVEGAMISVAAIVFIMGLNLLTVRLFGEL
EFWFALIKILAIIILIAVGLWMIFTGFTSTTGEVASFTHLWANGGFFPTGVHGFLAGFQIAIFAFVGVELVGTTAAETKD
PERNLPKAINSIPIRIIIFYVLALLIVMSVTPWNRIDPAISPFVNLFSQAGVAAAAILMNLVVLSSVMSSMNSGVFSTSR
MLFGLSREDQGPKAFGKLNRRAVPANALYFSAACLLLGAALQYFVPNTVEAFTLATTLSTILFICVWLLIIWSYIRYYTT
RPELHAKSTFKLPGGLFTCWITIIFFIGMIYVLSLEPDTFKALKVSPIWFVILIIGYFFFYKPRHKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=356, Percent_Identity=22.752808988764, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI181337167, Length=348, Percent_Identity=23.5632183908046, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=60.6521739130435, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=38.6609071274298, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1786602, Length=460, Percent_Identity=38.9130434782609, Blast_Score=314, Evalue=7e-87,
Organism=Escherichia coli, GI1786302, Length=462, Percent_Identity=37.012987012987, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=37.5824175824176, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI87081915, Length=458, Percent_Identity=36.4628820960699, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1789017, Length=436, Percent_Identity=33.256880733945, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788480, Length=397, Percent_Identity=36.7758186397985, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87081708, Length=477, Percent_Identity=31.2368972746331, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17540018, Length=348, Percent_Identity=25.8620689655172, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=414, Percent_Identity=23.1884057971014, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=429, Percent_Identity=22.6107226107226, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568033, Length=353, Percent_Identity=24.3626062322946, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=493, Percent_Identity=30.2231237322515, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=457, Percent_Identity=31.0722100656455, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=30.8755760368664, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=445, Percent_Identity=28.9887640449438, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=461, Percent_Identity=28.6334056399132, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=439, Percent_Identity=29.1571753986333, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324059, Length=419, Percent_Identity=29.1169451073986, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321629, Length=420, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324553, Length=454, Percent_Identity=29.0748898678414, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319824, Length=450, Percent_Identity=26.8888888888889, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=450, Percent_Identity=26.4444444444444, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=27.6283618581907, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=477, Percent_Identity=30.188679245283, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319542, Length=462, Percent_Identity=25.5411255411255, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321053, Length=473, Percent_Identity=26.215644820296, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319608, Length=456, Percent_Identity=25.219298245614, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320251, Length=485, Percent_Identity=23.9175257731959, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=487, Percent_Identity=22.9979466119097, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221331183, Length=364, Percent_Identity=24.7252747252747, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647653, Length=364, Percent_Identity=24.7252747252747, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664379, Length=364, Percent_Identity=24.7252747252747, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667468, Length=442, Percent_Identity=22.8506787330317, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24668806, Length=344, Percent_Identity=21.5116279069767, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21356285, Length=344, Percent_Identity=21.5116279069767, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24668802, Length=344, Percent_Identity=21.5116279069767, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24666159, Length=356, Percent_Identity=20.5056179775281, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221512776, Length=356, Percent_Identity=20.5056179775281, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51847; Mature: 51716

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQNLSDPHEQGELHRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYMIIG
CCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHH
LMVFFVMRALGELLLSNLTYKSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQFFNNGLPFSPVEGAMISVAAIVFIMGLNLLTVRLFGELEFWFALIKILAIIILIAVG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWMIFTGFTSTTGEVASFTHLWANGGFFPTGVHGFLAGFQIAIFAFVGVELVGTTAAETK
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
DPERNLPKAINSIPIRIIIFYVLALLIVMSVTPWNRIDPAISPFVNLFSQAGVAAAAILM
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NLVVLSSVMSSMNSGVFSTSRMLFGLSREDQGPKAFGKLNRRAVPANALYFSAACLLLGA
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALQYFVPNTVEAFTLATTLSTILFICVWLLIIWSYIRYYTTRPELHAKSTFKLPGGLFTC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
WITIIFFIGMIYVLSLEPDTFKALKVSPIWFVILIIGYFFFYKPRHKK
HHHHHHHHHHHHHHCCCCCCCHHEEECHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNQNLSDPHEQGELHRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYMIIG
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHH
LMVFFVMRALGELLLSNLTYKSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQFFNNGLPFSPVEGAMISVAAIVFIMGLNLLTVRLFGELEFWFALIKILAIIILIAVG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWMIFTGFTSTTGEVASFTHLWANGGFFPTGVHGFLAGFQIAIFAFVGVELVGTTAAETK
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
DPERNLPKAINSIPIRIIIFYVLALLIVMSVTPWNRIDPAISPFVNLFSQAGVAAAAILM
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NLVVLSSVMSSMNSGVFSTSRMLFGLSREDQGPKAFGKLNRRAVPANALYFSAACLLLGA
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALQYFVPNTVEAFTLATTLSTILFICVWLLIIWSYIRYYTTRPELHAKSTFKLPGGLFTC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
WITIIFFIGMIYVLSLEPDTFKALKVSPIWFVILIIGYFFFYKPRHKK
HHHHHHHHHHHHHHCCCCCCCHHEEECHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]