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The map label for this gene is purM [H]

Identifier: 213158291

GI number: 213158291

Start: 3107459

End: 3108529

Strand: Direct

Name: purM [H]

Synonym: AB57_3014

Alternate gene names: 213158291

Gene position: 3107459-3108529 (Clockwise)

Preceding gene: 213158286

Following gene: 213158292

Centisome position: 76.72

GC content: 42.2

Gene sequence:

>1071_bases
ATGAGCAACTCAACTTCTACCCCAAATACCGGTTTAAGCTACAAAGATGCGGGTGTTGACATTGAAGCGGGCGACGCACT
GGTCGATCGTATCAAGTCAGTCGCTAAACGTACAACTCGTCCAGAAGTAATGGGCGGACTTGGTGGCTTTGGTGCACTAT
GCAAAATTCCTAAAGGTTACGAAGAACCTGTTTTGGTTTCTGGAACTGACGGTGTAGGTACTAAATTACGTTTAGCACTT
AACCTTAATCGTCATGACACGATCGGCCAAGATCTTGTCGCTATGTGTGTAAACGATCTTTTGGTTTGTGGTGCAGAACC
ACTATTCTTCCTCGACTATTATGCGACTGGTCACTTAAATGTCGATGTAGCTGCAAACGTAGTTACTGGTATCGGTAAAG
GTTGTGAACTTGCAGGTTGCGCACTTGTAGGTGGTGAAACAGCTGAAATGCCTGGCATGTATGAAGGCGAAGATTACGAT
CTTGCTGGTTTTGCCGTAGGTGTAGTTGAGCAAAGCAAAATTATTGATGGCTCTAAAGTAAAATCTGGTGATGTACTTAT
TGGTGTTGCATCAAGCGGTGCTCACTCAAATGGTTATTCATTACTACGTAAAATCTTAGATGTTAAGAATGTAGACTTAA
CTCAAGTAATTGATGGTCGCCCTCTTGCAGATGTAGCAATGGAGCCAACACGTATTTATGTAAAACCAGTTCTAGAGCTT
TGCAAACAAGTTGATGTACACGCGATGGCACACATCACTGGTGGCGGCTTACCAGGTAACTTACCACGTGTATTACCAAA
TGGTGCTCAAGCTGTAATTAATGAAGCTTCTTGGGAATGGCCAGAATTATTCAAACTTTTACAACGCGAAGGCAATGTAG
AACGTTTTGAAATGTACCGTACCTTTAACTGTGGTGTAGGTATGGTCATTGCTGTTGATGCAAATGATGCAGAAAAAGCA
ATTGAAGTGCTTAATGCTCAAGGTGAAAAAGCTTGGAAAATCGGACATATCCAAGAAAATGCTGAATCAGTGGAAGGTGC
AGACGAAAAAATTCGTGTGATCTTTGAATGA

Upstream 100 bases:

>100_bases
TGGAAAATATTTTTATTAAAGATAGCATTTTCGAGCATAAATAACATAAGAGTTTCGTATATTCAGGTTATAATCTGCCG
CCAATGCGGAGACTTCATTT

Downstream 100 bases:

>100_bases
TGAAAATTGCTGTTCTAGTCTCTGGGAACGGCAGCAACTTACAAGCCTTGATAGATGCAAATCTATCAGGGCAAATTGTA
GGTGTACTGTCTAATAAAGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLAL
NLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYD
LAGFAVGVVEQSKIIDGSKVKSGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQVIDGRPLADVAMEPTRIYVKPVLEL
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVINEASWEWPELFKLLQREGNVERFEMYRTFNCGVGMVIAVDANDAEKA
IEVLNAQGEKAWKIGHIQENAESVEGADEKIRVIFE

Sequences:

>Translated_356_residues
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLAL
NLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYD
LAGFAVGVVEQSKIIDGSKVKSGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQVIDGRPLADVAMEPTRIYVKPVLEL
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVINEASWEWPELFKLLQREGNVERFEMYRTFNCGVGMVIAVDANDAEKA
IEVLNAQGEKAWKIGHIQENAESVEGADEKIRVIFE
>Mature_355_residues
SNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLALN
LNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDL
AGFAVGVVEQSKIIDGSKVKSGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQVIDGRPLADVAMEPTRIYVKPVLELC
KQVDVHAMAHITGGGLPGNLPRVLPNGAQAVINEASWEWPELFKLLQREGNVERFEMYRTFNCGVGMVIAVDANDAEKAI
EVLNAQGEKAWKIGHIQENAESVEGADEKIRVIFE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=49.5548961424332, Blast_Score=321, Evalue=6e-88,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=49.5548961424332, Blast_Score=321, Evalue=6e-88,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=49.5548961424332, Blast_Score=321, Evalue=6e-88,
Organism=Escherichia coli, GI1788845, Length=351, Percent_Identity=68.3760683760684, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17567511, Length=355, Percent_Identity=40.8450704225352, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=44.6629213483146, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24582400, Length=316, Percent_Identity=43.9873417721519, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37876; Mature: 37744

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGY
CCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCC
EEPVLVSGTDGVGTKLRLALNLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLN
CCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEE
VDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDLAGFAVGVVEQSKIIDGSKV
EEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCC
KSGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQVIDGRPLADVAMEPTRIYVKPVLEL
CCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCHHHHHCCCCEEHHHHHHHH
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVINEASWEWPELFKLLQREGNVERFEMYR
HHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEE
TFNCGVGMVIAVDANDAEKAIEVLNAQGEKAWKIGHIQENAESVEGADEKIRVIFE
EECCCCEEEEEEECCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure 
SNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGY
CCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCC
EEPVLVSGTDGVGTKLRLALNLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLN
CCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEE
VDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDLAGFAVGVVEQSKIIDGSKV
EEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCC
KSGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQVIDGRPLADVAMEPTRIYVKPVLEL
CCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCHHHHHCCCCEEHHHHHHHH
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVINEASWEWPELFKLLQREGNVERFEMYR
HHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEE
TFNCGVGMVIAVDANDAEKAIEVLNAQGEKAWKIGHIQENAESVEGADEKIRVIFE
EECCCCEEEEEEECCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA