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The map label for this gene is hemL [H]

Identifier: 213158178

GI number: 213158178

Start: 2986105

End: 2987403

Strand: Reverse

Name: hemL [H]

Synonym: AB57_2895

Alternate gene names: 213158178

Gene position: 2987403-2986105 (Counterclockwise)

Preceding gene: 213158179

Following gene: 213158177

Centisome position: 73.75

GC content: 42.03

Gene sequence:

>1299_bases
ATGAGTTTATCTCCAAAGCAAGAACAGTTATTTAAACAAGCCAGCAAACACATTCCAGGTGGTGTGAACTCTCCGGTACG
TGCCTTTAATGGCGTTGGAGGCACACCGGTTTTCATTGAGAAAGCCAAAGGTGCGTATTTGTGGGATGTAGATGGTAAGC
GCTATGTAGATTATGTTGGCTCTTGGGGACCAATGATTTTGGGCCATGCTCATCCGGATATTATTAAGGCTGTGCAAACA
GCAGCAGAAGATGGCTTAAGTTTTGGTGCACCAACCGTACACGAAACAACGTTGGCAGATATTATTTGTGAAATCATGCC
ATCTATTGAATTGGTACGTATGACCAACTCTGGTACAGAAGCGACCATGACTGCTATTCGTTTAGCACGTGGTTATACTG
GCCGTGACAAGATCGTGAAGTTTGAGGGTTGTTACCACGGGCACTCTGACTCATTGTTAGTAAAAGCAGGTTCTGGTTTA
TTAACTAAAGGTGAGGGCGAACCAACATCAAAAGGTGTACCAGCTGACTTTGCTAAACATACTTTAACACTGCCATATAA
CGATATTGCAGCATTAAAAGAATGCTTTGCTAAATTTGGTCATGAAATTGCGGGCGTCATTATTGAACCTGTCGCAGGTA
ATATGAATATGGTGAAACCAATTGATGGTTTCTTACAAGCGATTCGTGATGTGTGTGATGAATACAAATCTGTATTTATT
ATTGACGAAGTAATGACAGGTTTCCGCGTTGCATTGGGCGGTGCTCAGTCAGTTTATAACGTTAAACCTGACTTAACGAC
TTTGGGTAAAATTATTGGTGCTGGTTTACCTGTAGGTGCATTTGGCGGTAAGCGTGAAATCATGGAATGCATCGCACCTT
TAGGGGGTGTATACCAAGCGGGGACTTTATCTGGTAACCCACTTGCTATGCGTGCTGGTATTGAAATGTTTAAACATTTA
CGTCAACCGGACTTTTACAGCAAGTTATCTGCTCAACTTGAAAAGTTACTTGCAGGTTTACAAGCAGCAGCAGATGAAGC
GGGTATTCCATTTAAAACTCAGCAAGCTGGCGCAATGTTTGGGCTTTACTTTACTGACCAAGAAGACATCACAAGCTTTG
ACTCTATGTTGGCATGTGATATTGAAGCTTTCAAAAAGTTCTTCCATGGCATGTTAAAACGTGGCGTAAACTTGGCACCG
TCAGCATTTGAAGCAGGCTTTATTTCATCTGCTCATTCTGATGAAGATATCGAGTTTACCATTCAGGCTGCAAAAGAAAC
CTTTGCCGAAATGAAGTAA

Upstream 100 bases:

>100_bases
TCGATCAACTGCTGAAATTCCTGCCCGTGTACAGGCGTGGGCAAAATTATTTTCTTAAGCTTTCAAAATTATTTTTTAGA
TATTTAAGACGAGCATTTCC

Downstream 100 bases:

>100_bases
GCAAAAAGGCCCGTTTTAAACGGGCTTTTTAATTTGAGCTATTTTATATTTGTAGAGAACAATGTTTTATCCCTTACCTC
GAAAAATCCAGTTAGCCGCA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVGSWGPMILGHAHPDIIKAVQT
AAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGL
LTKGEGEPTSKGVPADFAKHTLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFI
IDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGIEMFKHL
RQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMFGLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAP
SAFEAGFISSAHSDEDIEFTIQAAKETFAEMK

Sequences:

>Translated_432_residues
MSLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVGSWGPMILGHAHPDIIKAVQT
AAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGL
LTKGEGEPTSKGVPADFAKHTLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFI
IDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGIEMFKHL
RQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMFGLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAP
SAFEAGFISSAHSDEDIEFTIQAAKETFAEMK
>Mature_431_residues
SLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVGSWGPMILGHAHPDIIKAVQTA
AEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLL
TKGEGEPTSKGVPADFAKHTLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFII
DEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGIEMFKHLR
QPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMFGLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAPS
AFEAGFISSAHSDEDIEFTIQAAKETFAEMK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=31.3531353135314, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI37574042, Length=307, Percent_Identity=27.0358306188925, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI24119277, Length=307, Percent_Identity=26.0586319218241, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI284507298, Length=220, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226442705, Length=307, Percent_Identity=26.0586319218241, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI226442709, Length=276, Percent_Identity=27.1739130434783, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=62.4413145539906, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1789016, Length=395, Percent_Identity=29.1139240506329, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789759, Length=309, Percent_Identity=30.0970873786408, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI145693181, Length=412, Percent_Identity=27.4271844660194, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788044, Length=334, Percent_Identity=28.4431137724551, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787560, Length=283, Percent_Identity=30.3886925795053, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786991, Length=394, Percent_Identity=27.9187817258883, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=317, Percent_Identity=27.1293375394322, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=161, Percent_Identity=29.8136645962733, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=325, Percent_Identity=28.9230769230769, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=330, Percent_Identity=24.8484848484848, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357415, Length=299, Percent_Identity=27.7591973244147, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46406; Mature: 46275

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVG
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEECCCCHHHHHHC
SWGPMILGHAHPDIIKAVQTAAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCH
ATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTKGEGEPTSKGVPADFAKH
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCHHHHC
TLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFI
EEECCCHHHHHHHHHHHHHCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEH
IDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQA
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEC
GTLSGNPLAMRAGIEMFKHLRQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMF
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
GLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAPSAFEAGFISSAHSDEDIEFT
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCEEE
IQAAKETFAEMK
HHHHHHHHHHCC
>Mature Secondary Structure 
SLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVG
CCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEECCCCHHHHHHC
SWGPMILGHAHPDIIKAVQTAAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCH
ATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTKGEGEPTSKGVPADFAKH
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCHHHHC
TLTLPYNDIAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFI
EEECCCHHHHHHHHHHHHHCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEH
IDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQA
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEC
GTLSGNPLAMRAGIEMFKHLRQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMF
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
GLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAPSAFEAGFISSAHSDEDIEFT
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCEEE
IQAAKETFAEMK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA