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The map label for this gene is kdc [H]

Identifier: 213158163

GI number: 213158163

Start: 2967826

End: 2969547

Strand: Reverse

Name: kdc [H]

Synonym: AB57_2877

Alternate gene names: 213158163

Gene position: 2969547-2967826 (Counterclockwise)

Preceding gene: 213158165

Following gene: 213158162

Centisome position: 73.31

GC content: 39.43

Gene sequence:

>1722_bases
ATGTTCATAGAAATTGGTGAATTTTTAAATCTTCGTCTAAAACAAATGGGTATCCAACATCTTTTTGGTGTACCTGGTGA
TTTTAACCTCTCATATCTAGAACAAGTTGAAGCAGACCCACAACTCGAATTTATTGGAAATTGTAATGAATTAAATGCTG
CCTATGCAGCAGACGGTTATGCACGAATTAACGGTTTTTCTGCCTTGGCAACCACTTATGGTGTAGGTGACTTAAGTGCC
ATTAATGGTATTGCAGGTGCCTATGCAGAAAATGTACCTCTTATTCATATCTCAGGTATTCCACCTTTACATGCAGTTCA
AAAGGGTACTCTCATACACCATACGTTAGTTGATGGTAACTACGACAACATTATGAACTGTATGAAAGAGTTCACAGTTG
CCCAAACTCGTTTAACTCCTGCAAATGCAGCTTCTGAAATTGACCGTGTATTGCGTCAGTGTTTCCTTGAACGCCGTCCT
GTACATATCCAACTACCTGGTGATATTACTCACGTTAAGATTGAAGTGTCTGAGCGTCCACTCGACTTAAGCTATCCAGC
TGTTGAACCTGAATTATTGCAAAGTGTGGTAAGCAAACTTTGTGACATTATTGAAAATGCTCAAAGTCCAGCGCTTTTAA
TTGATAATGAAGCCTCAGTTTTTGGTGTAACTTCACTTTTAAATGATTTGTCTCAGAAATGCTCAATTCCATTTGCAGGT
ATGAATACTGCAAAAAATATTATGGATGAAGGCTCACCTCGTTACATCGGAACTTATGTGGGTGGAGCAAGCCAACCGCA
TGTAAAAAATATCATTGAACAATCTGACTGTTTAATTGGTGTTGGCGCGCGCTTTACCGATGTAGGCTCAGCTGTATTTA
CGCATCAAATTGAGACCAAGAACTATATCGAAATTAAATCTTACGGCTTAAATATTTTTGGTCAGGATTTTCCGGGTATT
GAAATTGGACAATTACTTGTCGAGCTAAATAAAAAAGTTGCGCCACGTAAATCGTCAATACCTTTTCTTGAAAAACAACC
TCAGAAAGTAATTGAAGCGCCAGCTCAACAGAAGCTTAGCCAAGATGTGCTTTGGAACTACATTTCAGGGTTCTTAAAAG
AAGATGATGTGATTATTGGTGAAGTAGGAACATCAAACTCTGCTTTGTCAGGTATCAAACTTCCTGCTACAGCTAAATAT
ATTGCGCAGCCGCTTTGGGGTTCTATTGGTTATACCTTGCCAGCTTTGCTTGGTAGTTTGTTAGCTGCCCCTGAGCGTCG
TCAAATTTTGTTTATTGGTGACGGTTCGTTCCAGCTTACGGTACAAGAACTCTCTACGATTATCCGCCATGGTTTAAAAC
CAATTATTTTCTTGTTGAACAATGGCGGCTACACCATTGAACGTTTAATTATGGGTGAAAACGCTGCCTATAACGACGTG
CAAAACTGGAAATACACTGAAATTCCAGCGGTATTTAACGGTAAAAAAGGCCATACCACTTACGTGGTTGAGACTGCTGG
CCAACTGAAGAGCGTTTTAGATAATGTTCAGCAAAATGATCAGTTAACTTTCATTGAATTGAAACTACCAGCAATGGATG
CGCCAGTGAGTTTGAAAAAATTTGCTTCTGTGATTGCACGTTTTGACTACGGTGATCGCGGCTACGAAATTTTAAAGGAG
CGTTCCCAACCCGTTAAATGTAAGGATGCAATCTCTTTTTAA

Upstream 100 bases:

>100_bases
ATTTTTATTAAAATGCGTTTTCATTATGCACGAAATCTAAAAGATAGATGAAATATTATTTTTCTATGGAATAAAAATTG
GTCTCAAAGGATATAGAGCA

Downstream 100 bases:

>100_bases
ATAGAAGATAGGACACGTCTTCTCAAAAATTAAATGGACTCATACTAAAGCAACTTATGTCCGAAGGTCGGTTTCTGGCC
TTCGGATATGGTGCTGAATA

Product: indole-3-pyruvate decarboxylase

Products: 2-(indol-3-yl)acetaldehyde; CO2

Alternate protein names: KDC [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MFIEIGEFLNLRLKQMGIQHLFGVPGDFNLSYLEQVEADPQLEFIGNCNELNAAYAADGYARINGFSALATTYGVGDLSA
INGIAGAYAENVPLIHISGIPPLHAVQKGTLIHHTLVDGNYDNIMNCMKEFTVAQTRLTPANAASEIDRVLRQCFLERRP
VHIQLPGDITHVKIEVSERPLDLSYPAVEPELLQSVVSKLCDIIENAQSPALLIDNEASVFGVTSLLNDLSQKCSIPFAG
MNTAKNIMDEGSPRYIGTYVGGASQPHVKNIIEQSDCLIGVGARFTDVGSAVFTHQIETKNYIEIKSYGLNIFGQDFPGI
EIGQLLVELNKKVAPRKSSIPFLEKQPQKVIEAPAQQKLSQDVLWNYISGFLKEDDVIIGEVGTSNSALSGIKLPATAKY
IAQPLWGSIGYTLPALLGSLLAAPERRQILFIGDGSFQLTVQELSTIIRHGLKPIIFLLNNGGYTIERLIMGENAAYNDV
QNWKYTEIPAVFNGKKGHTTYVVETAGQLKSVLDNVQQNDQLTFIELKLPAMDAPVSLKKFASVIARFDYGDRGYEILKE
RSQPVKCKDAISF

Sequences:

>Translated_573_residues
MFIEIGEFLNLRLKQMGIQHLFGVPGDFNLSYLEQVEADPQLEFIGNCNELNAAYAADGYARINGFSALATTYGVGDLSA
INGIAGAYAENVPLIHISGIPPLHAVQKGTLIHHTLVDGNYDNIMNCMKEFTVAQTRLTPANAASEIDRVLRQCFLERRP
VHIQLPGDITHVKIEVSERPLDLSYPAVEPELLQSVVSKLCDIIENAQSPALLIDNEASVFGVTSLLNDLSQKCSIPFAG
MNTAKNIMDEGSPRYIGTYVGGASQPHVKNIIEQSDCLIGVGARFTDVGSAVFTHQIETKNYIEIKSYGLNIFGQDFPGI
EIGQLLVELNKKVAPRKSSIPFLEKQPQKVIEAPAQQKLSQDVLWNYISGFLKEDDVIIGEVGTSNSALSGIKLPATAKY
IAQPLWGSIGYTLPALLGSLLAAPERRQILFIGDGSFQLTVQELSTIIRHGLKPIIFLLNNGGYTIERLIMGENAAYNDV
QNWKYTEIPAVFNGKKGHTTYVVETAGQLKSVLDNVQQNDQLTFIELKLPAMDAPVSLKKFASVIARFDYGDRGYEILKE
RSQPVKCKDAISF
>Mature_573_residues
MFIEIGEFLNLRLKQMGIQHLFGVPGDFNLSYLEQVEADPQLEFIGNCNELNAAYAADGYARINGFSALATTYGVGDLSA
INGIAGAYAENVPLIHISGIPPLHAVQKGTLIHHTLVDGNYDNIMNCMKEFTVAQTRLTPANAASEIDRVLRQCFLERRP
VHIQLPGDITHVKIEVSERPLDLSYPAVEPELLQSVVSKLCDIIENAQSPALLIDNEASVFGVTSLLNDLSQKCSIPFAG
MNTAKNIMDEGSPRYIGTYVGGASQPHVKNIIEQSDCLIGVGARFTDVGSAVFTHQIETKNYIEIKSYGLNIFGQDFPGI
EIGQLLVELNKKVAPRKSSIPFLEKQPQKVIEAPAQQKLSQDVLWNYISGFLKEDDVIIGEVGTSNSALSGIKLPATAKY
IAQPLWGSIGYTLPALLGSLLAAPERRQILFIGDGSFQLTVQELSTIIRHGLKPIIFLLNNGGYTIERLIMGENAAYNDV
QNWKYTEIPAVFNGKKGHTTYVVETAGQLKSVLDNVQQNDQLTFIELKLPAMDAPVSLKKFASVIARFDYGDRGYEILKE
RSQPVKCKDAISF

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes [H]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=478, Percent_Identity=24.0585774058577, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531299, Length=559, Percent_Identity=23.4347048300537, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17531301, Length=559, Percent_Identity=23.4347048300537, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321524, Length=556, Percent_Identity=41.5467625899281, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323163, Length=556, Percent_Identity=39.2086330935252, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323073, Length=558, Percent_Identity=38.7096774193548, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320123, Length=555, Percent_Identity=34.5945945945946, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6320588, Length=604, Percent_Identity=31.7880794701987, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323755, Length=508, Percent_Identity=22.8346456692913, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: 4.1.1.74

Molecular weight: Translated: 62889; Mature: 62889

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIEIGEFLNLRLKQMGIQHLFGVPGDFNLSYLEQVEADPQLEFIGNCNELNAAYAADGY
CEEECCHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHCCCC
ARINGFSALATTYGVGDLSAINGIAGAYAENVPLIHISGIPPLHAVQKGTLIHHTLVDGN
CEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEEEECCC
YDNIMNCMKEFTVAQTRLTPANAASEIDRVLRQCFLERRPVHIQLPGDITHVKIEVSERP
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCC
LDLSYPAVEPELLQSVVSKLCDIIENAQSPALLIDNEASVFGVTSLLNDLSQKCSIPFAG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
MNTAKNIMDEGSPRYIGTYVGGASQPHVKNIIEQSDCLIGVGARFTDVGSAVFTHQIETK
CCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCEEECCCCHHHHCCHHHEEEECCC
NYIEIKSYGLNIFGQDFPGIEIGQLLVELNKKVAPRKSSIPFLEKQPQKVIEAPAQQKLS
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHCCHHHHHHH
QDVLWNYISGFLKEDDVIIGEVGTSNSALSGIKLPATAKYIAQPLWGSIGYTLPALLGSL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAAPERRQILFIGDGSFQLTVQELSTIIRHGLKPIIFLLNNGGYTIERLIMGENAAYNDV
HCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
QNWKYTEIPAVFNGKKGHTTYVVETAGQLKSVLDNVQQNDQLTFIELKLPAMDAPVSLKK
CCCEEEECCCEECCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHH
FASVIARFDYGDRGYEILKERSQPVKCKDAISF
HHHHHHHCCCCCCHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MFIEIGEFLNLRLKQMGIQHLFGVPGDFNLSYLEQVEADPQLEFIGNCNELNAAYAADGY
CEEECCHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHCCCC
ARINGFSALATTYGVGDLSAINGIAGAYAENVPLIHISGIPPLHAVQKGTLIHHTLVDGN
CEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEEEECCC
YDNIMNCMKEFTVAQTRLTPANAASEIDRVLRQCFLERRPVHIQLPGDITHVKIEVSERP
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCC
LDLSYPAVEPELLQSVVSKLCDIIENAQSPALLIDNEASVFGVTSLLNDLSQKCSIPFAG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
MNTAKNIMDEGSPRYIGTYVGGASQPHVKNIIEQSDCLIGVGARFTDVGSAVFTHQIETK
CCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCEEECCCCHHHHCCHHHEEEECCC
NYIEIKSYGLNIFGQDFPGIEIGQLLVELNKKVAPRKSSIPFLEKQPQKVIEAPAQQKLS
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHCCHHHHHHH
QDVLWNYISGFLKEDDVIIGEVGTSNSALSGIKLPATAKYIAQPLWGSIGYTLPALLGSL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAAPERRQILFIGDGSFQLTVQELSTIIRHGLKPIIFLLNNGGYTIERLIMGENAAYNDV
HCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
QNWKYTEIPAVFNGKKGHTTYVVETAGQLKSVLDNVQQNDQLTFIELKLPAMDAPVSLKK
CCCEEEECCCEECCCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHH
FASVIARFDYGDRGYEILKERSQPVKCKDAISF
HHHHHHHCCCCCCHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-(indol-3-yl)pyruvate

Specific reaction: 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]