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The map label for this gene is aroP [H]

Identifier: 213158162

GI number: 213158162

Start: 2966306

End: 2967685

Strand: Reverse

Name: aroP [H]

Synonym: AB57_2876

Alternate gene names: 213158162

Gene position: 2967685-2966306 (Counterclockwise)

Preceding gene: 213158163

Following gene: 213158161

Centisome position: 73.27

GC content: 39.86

Gene sequence:

>1380_bases
ATGGATGTAAACAATAAGCACGAGTTAAAACAAGGCTTATCCAATCGGCATATTCAACTCATCGCACTCGGAGGGGCGAT
CGGAACAGGGTTATTCTTAGGTCTATCACAAACAATTAAACTGGCAGGTCCTTCAATTTTATTGGGATATGCAATTGCAG
GAATTATTGCCTTTTTGATTATGCGTCATTTAGGTGAAATGGTTGTTGAAGAACCGGTAAGTGGTTCTTTTAGTTATTTT
GCGAACAAATACTGGGGCAAAATGGCTGGTTTTATGTCTGGCTGGAACTACTGGGTTTTGTATGTACTGGTAAGTATGGC
CGAACTGAGTGCGATTGGTACTTTTATTCAGTTTTGGTGGCCAGAAATTCCGACATGGCTGACCGCTCTATTTTTCTTTA
TTTTAATTAACGGCATTAACTTGGTAAATGTCCGCTTTTTTGGGGAATCGGAGTTCTTATTTTCCTGCATTAAAATTGTT
GCGATTTTAAGTATGATTGGCTTCGGTGCTTATCTTTTACTTTCAGGCTCAGCAGGTCCGCAAGCGGGTATTGCAAATTT
ATGGCAACACGGTGGTTTCTTCCCGCATGGTATTCATGGCTTTATTATGGCCTTGGCTGTCATTATGTTTGCATTCGGTG
GTCTAGAGCTTATCGGTATTGCAGCAGCTGAAACGAAAAAACCTGAAACAACAATTCCAAAGGCAGTAAACCAGATTGTT
TATCGCATCCTGATTTTTTACATTGGTGCAATCGGTATTCTTTTATGTCTTTATCCATGGAATATGGTGGCAGAAGGCGG
TAGTCCGTTTGTCTTAATTTTCCAGTCCCTCAATAGTAATGGCGTTGCGAATGTTCTGAACTTTGTGGTCTTGATTGCTG
CTATTTCGGTTTATAACAGTTGTATTTACTGTAATAGTCGTATGTTGCATGGTTTAGCAGAGCAGGGCAATGCGCCAGCA
ATTTTGAAAAAAGTGAACAGCCGCGGTATTCCAGTTCCAGCAGCAGTTGTTTCTGCTTCAATTACAGCAGTCTGTGTAGT
GGTCAACTATTTAATTCCAGGTCAAGCTTTTCAGCTCTTTATGATGTTGGTTGTGGCTGCGCTTGTTATTAACTGGCTTA
TGATCTCAGTCACGCATTTGAAATTTACCAAAGCAATGAAATTGCAAAAGCGTCAAACCAAATTCCAAAGCATTATGAGC
CCATGGAGTAATTATTTAACTATTAGCTTTGTATGTTTCATTCTCATTATTATGGCGATGACACCAGATATGAGGCTCGC
TGTTATTTTGGGGCCTATCTGGCTTGCTGTTTTAGCGATTATGTATTTCTTTAAGTATCGTAAAAAAATGGTCGCAATGC
CGGAAGTACAATCAAACTAA

Upstream 100 bases:

>100_bases
CATACTAAAGCAACTTATGTCCGAAGGTCGGTTTCTGGCCTTCGGATATGGTGCTGAATAAAGGTGTACAGGAAGTGACA
CCAACATTGGAGATAATGTT

Downstream 100 bases:

>100_bases
TAAGCTAAATTTACAGTGATGTTGCGGTTATCTGACATAAGGCAGGTAACCGTTTTTGTTTTGTCATAATATTTTCATGT
TCGGGCGAAATAATTTTTTA

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MDVNNKHELKQGLSNRHIQLIALGGAIGTGLFLGLSQTIKLAGPSILLGYAIAGIIAFLIMRHLGEMVVEEPVSGSFSYF
ANKYWGKMAGFMSGWNYWVLYVLVSMAELSAIGTFIQFWWPEIPTWLTALFFFILINGINLVNVRFFGESEFLFSCIKIV
AILSMIGFGAYLLLSGSAGPQAGIANLWQHGGFFPHGIHGFIMALAVIMFAFGGLELIGIAAAETKKPETTIPKAVNQIV
YRILIFYIGAIGILLCLYPWNMVAEGGSPFVLIFQSLNSNGVANVLNFVVLIAAISVYNSCIYCNSRMLHGLAEQGNAPA
ILKKVNSRGIPVPAAVVSASITAVCVVVNYLIPGQAFQLFMMLVVAALVINWLMISVTHLKFTKAMKLQKRQTKFQSIMS
PWSNYLTISFVCFILIIMAMTPDMRLAVILGPIWLAVLAIMYFFKYRKKMVAMPEVQSN

Sequences:

>Translated_459_residues
MDVNNKHELKQGLSNRHIQLIALGGAIGTGLFLGLSQTIKLAGPSILLGYAIAGIIAFLIMRHLGEMVVEEPVSGSFSYF
ANKYWGKMAGFMSGWNYWVLYVLVSMAELSAIGTFIQFWWPEIPTWLTALFFFILINGINLVNVRFFGESEFLFSCIKIV
AILSMIGFGAYLLLSGSAGPQAGIANLWQHGGFFPHGIHGFIMALAVIMFAFGGLELIGIAAAETKKPETTIPKAVNQIV
YRILIFYIGAIGILLCLYPWNMVAEGGSPFVLIFQSLNSNGVANVLNFVVLIAAISVYNSCIYCNSRMLHGLAEQGNAPA
ILKKVNSRGIPVPAAVVSASITAVCVVVNYLIPGQAFQLFMMLVVAALVINWLMISVTHLKFTKAMKLQKRQTKFQSIMS
PWSNYLTISFVCFILIIMAMTPDMRLAVILGPIWLAVLAIMYFFKYRKKMVAMPEVQSN
>Mature_459_residues
MDVNNKHELKQGLSNRHIQLIALGGAIGTGLFLGLSQTIKLAGPSILLGYAIAGIIAFLIMRHLGEMVVEEPVSGSFSYF
ANKYWGKMAGFMSGWNYWVLYVLVSMAELSAIGTFIQFWWPEIPTWLTALFFFILINGINLVNVRFFGESEFLFSCIKIV
AILSMIGFGAYLLLSGSAGPQAGIANLWQHGGFFPHGIHGFIMALAVIMFAFGGLELIGIAAAETKKPETTIPKAVNQIV
YRILIFYIGAIGILLCLYPWNMVAEGGSPFVLIFQSLNSNGVANVLNFVVLIAAISVYNSCIYCNSRMLHGLAEQGNAPA
ILKKVNSRGIPVPAAVVSASITAVCVVVNYLIPGQAFQLFMMLVVAALVINWLMISVTHLKFTKAMKLQKRQTKFQSIMS
PWSNYLTISFVCFILIIMAMTPDMRLAVILGPIWLAVLAIMYFFKYRKKMVAMPEVQSN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=380, Percent_Identity=21.5789473684211, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI258614003, Length=380, Percent_Identity=21.5789473684211, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258645169, Length=379, Percent_Identity=21.6358839050132, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=61.5730337078652, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=59.4170403587444, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI48994972, Length=452, Percent_Identity=42.0353982300885, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=42.2566371681416, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1790653, Length=449, Percent_Identity=37.1937639198218, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=36.1305361305361, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87081915, Length=454, Percent_Identity=33.7004405286344, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI87081708, Length=464, Percent_Identity=31.6810344827586, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788480, Length=395, Percent_Identity=35.1898734177215, Blast_Score=222, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=32.4263038548753, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324061, Length=436, Percent_Identity=30.9633027522936, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322892, Length=435, Percent_Identity=31.264367816092, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6321053, Length=421, Percent_Identity=30.6413301662708, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=469, Percent_Identity=29.4243070362473, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=441, Percent_Identity=30.3854875283447, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=415, Percent_Identity=30.6024096385542, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=422, Percent_Identity=30.3317535545024, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=28.8177339901478, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=443, Percent_Identity=29.3453724604966, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=435, Percent_Identity=28.9655172413793, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=28.0788177339901, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=432, Percent_Identity=28.9351851851852, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319608, Length=434, Percent_Identity=27.4193548387097, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=410, Percent_Identity=29.2682926829268, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=28.0788177339901, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=405, Percent_Identity=28.8888888888889, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=487, Percent_Identity=24.6406570841889, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666159, Length=280, Percent_Identity=22.8571428571429, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512776, Length=280, Percent_Identity=22.8571428571429, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50503; Mature: 50503

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVNNKHELKQGLSNRHIQLIALGGAIGTGLFLGLSQTIKLAGPSILLGYAIAGIIAFLI
CCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MRHLGEMVVEEPVSGSFSYFANKYWGKMAGFMSGWNYWVLYVLVSMAELSAIGTFIQFWW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PEIPTWLTALFFFILINGINLVNVRFFGESEFLFSCIKIVAILSMIGFGAYLLLSGSAGP
CCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
QAGIANLWQHGGFFPHGIHGFIMALAVIMFAFGGLELIGIAAAETKKPETTIPKAVNQIV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCCCCCHHHHHHHHHH
YRILIFYIGAIGILLCLYPWNMVAEGGSPFVLIFQSLNSNGVANVLNFVVLIAAISVYNS
HHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
CIYCNSRMLHGLAEQGNAPAILKKVNSRGIPVPAAVVSASITAVCVVVNYLIPGQAFQLF
HHHCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MMLVVAALVINWLMISVTHLKFTKAMKLQKRQTKFQSIMSPWSNYLTISFVCFILIIMAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPDMRLAVILGPIWLAVLAIMYFFKYRKKMVAMPEVQSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDVNNKHELKQGLSNRHIQLIALGGAIGTGLFLGLSQTIKLAGPSILLGYAIAGIIAFLI
CCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MRHLGEMVVEEPVSGSFSYFANKYWGKMAGFMSGWNYWVLYVLVSMAELSAIGTFIQFWW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PEIPTWLTALFFFILINGINLVNVRFFGESEFLFSCIKIVAILSMIGFGAYLLLSGSAGP
CCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
QAGIANLWQHGGFFPHGIHGFIMALAVIMFAFGGLELIGIAAAETKKPETTIPKAVNQIV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCCCCCHHHHHHHHHH
YRILIFYIGAIGILLCLYPWNMVAEGGSPFVLIFQSLNSNGVANVLNFVVLIAAISVYNS
HHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
CIYCNSRMLHGLAEQGNAPAILKKVNSRGIPVPAAVVSASITAVCVVVNYLIPGQAFQLF
HHHCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MMLVVAALVINWLMISVTHLKFTKAMKLQKRQTKFQSIMSPWSNYLTISFVCFILIIMAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPDMRLAVILGPIWLAVLAIMYFFKYRKKMVAMPEVQSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]