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The map label for this gene is trpC

Identifier: 213158078

GI number: 213158078

Start: 2865940

End: 2866746

Strand: Direct

Name: trpC

Synonym: AB57_2790

Alternate gene names: 213158078

Gene position: 2865940-2866746 (Clockwise)

Preceding gene: 213158077

Following gene: 213158079

Centisome position: 70.75

GC content: 39.28

Gene sequence:

>807_bases
ATGATTAATATTCAAAATACCATTTTAGGTAAAATTGTTGACCGTAAACATGAGGAACTTGCTGCGCGTTTAAAACAACG
TAATTTGCAAGATGTAGAAGAGCTTGCAAAAGCAGCGACTCCGGTGCGTGGCTTTGCAAATGCTTTACAACATAAACGTC
CGGGCGTGATTGCTGAAATTAAAAAAGCATCTCCATCAAAAGGAATCATTCGCGCAGACTTTAATCCTGCCGAAATTGCT
CAGCAATATGAACAAGCTGGAGCAGCATGTTTATCGGTATTGACCGATGTTGATTTCTTTCAGGGTGCAGATGAAAATAT
TGCGATTGCCCGTAATCATTGTGCCCTACCTGCTTTACGTAAAGACTTTTTGGTCGACCCGTACAATGTAGTTGAAGCAC
GTGCTTTGCATGCTGACTGTATTTTATTAATTGTTGCTTGTTTGTCTGACCAGCAACTCGAAGAAATGTCTAAAACTGCG
TTTGAGCATCAACTTGATGTATTGGTTGAAGTTCATGACGAAGAAGAGTTAGAGCGTGCCTTAAAGCTTTCTGAGCAATG
TTTATTAGGCGTAAATAACCGTAATTTAAAAACCTTTGATGTAGATTTAAATACTACTATTCGGTTGAAAAAATTACTTC
CGGCCTCACGTTTATTGATCACTGAAAGTGGTATTGCGACACCAGATGATGTACGTATGATGCAAGAGCATGATATTCAC
AGTTTCTTGGTTGGCGAAAGTTTTATGAAACAACCACGTCCAGATCAAGCTTTTACTGCCCTTTTTGGACAACCTCAAAC
GGTTTAA

Upstream 100 bases:

>100_bases
TCAAGATATTATTTACGGCGGGCAAGCATTAGAGAAAATGAGTGTTTTAGCTGAATTTACTAAAACATTAAAACAATCTC
AGGCAGATTAAGGACTTCTC

Downstream 100 bases:

>100_bases
TGAAGATATATGAGTAATAAAGATTCATCGCTTTCTAAAGAGCAACAAAAGTTATTGAAGCAATTTAAAAAGCAAATCTC
CAATCCTCATTCAAGCAAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MINIQNTILGKIVDRKHEELAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEIKKASPSKGIIRADFNPAEIA
QQYEQAGAACLSVLTDVDFFQGADENIAIARNHCALPALRKDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTA
FEHQLDVLVEVHDEEELERALKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIH
SFLVGESFMKQPRPDQAFTALFGQPQTV

Sequences:

>Translated_268_residues
MINIQNTILGKIVDRKHEELAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEIKKASPSKGIIRADFNPAEIA
QQYEQAGAACLSVLTDVDFFQGADENIAIARNHCALPALRKDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTA
FEHQLDVLVEVHDEEELERALKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIH
SFLVGESFMKQPRPDQAFTALFGQPQTV
>Mature_268_residues
MINIQNTILGKIVDRKHEELAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEIKKASPSKGIIRADFNPAEIA
QQYEQAGAACLSVLTDVDFFQGADENIAIARNHCALPALRKDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTA
FEHQLDVLVEVHDEEELERALKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIH
SFLVGESFMKQPRPDQAFTALFGQPQTV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=243, Percent_Identity=40.7407407407407, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=261, Percent_Identity=38.3141762452107, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_ACIB5 (B7I441)

Other databases:

- EMBL:   CP001182
- RefSeq:   YP_002320129.1
- ProteinModelPortal:   B7I441
- SMR:   B7I441
- GeneID:   7046917
- GenomeReviews:   CP001182_GR
- KEGG:   abn:AB57_2790
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29912; Mature: 29912

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIQNTILGKIVDRKHEELAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KKASPSKGIIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARNHCALPALR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
KDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTAFEHQLDVLVEVHDEEELERA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHH
LKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIH
HHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHCHH
SFLVGESFMKQPRPDQAFTALFGQPQTV
HHHHHHHHHCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MINIQNTILGKIVDRKHEELAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KKASPSKGIIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARNHCALPALR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
KDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTAFEHQLDVLVEVHDEEELERA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHH
LKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIH
HHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHCHH
SFLVGESFMKQPRPDQAFTALFGQPQTV
HHHHHHHHHCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA