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The map label for this gene is maeB [H]

Identifier: 213158061

GI number: 213158061

Start: 2841535

End: 2843805

Strand: Direct

Name: maeB [H]

Synonym: AB57_2773

Alternate gene names: 213158061

Gene position: 2841535-2843805 (Clockwise)

Preceding gene: 213158060

Following gene: 213158062

Centisome position: 70.15

GC content: 40.11

Gene sequence:

>2271_bases
ATGGACGATCAATCTTTAAAACAGGCCGCTTTAAATTACCACGAATATCCAAATCCAGGGAAAATCAGCGTCACGCCAAG
TAAGCAACTTGTCAACCAACGAGATTTGGCTCTAGCTTATTCACCAGGGGTTGCTGCTCCATGTTTAGAGATTGAACGTG
ATCCTTCAGCTGCTGCAAAATATACAGCGCGTGGTAACTTGGTTGCTGTTGTCAGTAACGGTACTGCGGTTCTTGGTTTA
GGTAATATTGGTCCATTAGCTTCTAAACCGGTAATGGAAGGTAAAGGCGTTCTGTTCAAAAAGTTCGCTGGTGTCGATGT
ATTTGATATTGAAATTGCTGAAAACGATCCAGATAAAATCGTTGATATTGTTGCTTCATTAGAACCAACTTTCGGCGGTA
TTAACCTTGAAGATATCAAAGCGCCTGAATGTTTCTACATTGAAAAGAAACTTCGTGAACGCATGAAAATTCCTGTGTTC
CATGATGACCAACACGGAACAAGTATTATTGTAGGTTCAGCATTATTAAATGCTCTACAAATCGTTAATAAGAAAATTGA
AGAAATCAAAATCGTTGCTTCAGGTGCAGGTGCTGCTGCCCTTTCTTGTTTAGATTTACTTTGTGCTTTAGGCGTAAATA
AAGAAAATATCATTGTTGCCGATTCTCGTGGTCTTCTTACAACTTCACGTGAAGGCTTAGATGAATCGAAAAAACGTTAT
GTACAAGACATTAAAGCGACCCAATTACATGAAGTAATGGCTGGCGCGGATATGTTCTTAGGTCTTTCAGCTGCTGGTAT
TCTCACCAAAGATATGGTGAAACAAATGGCTGAAAATCCGATTATCTTTGCATTAGCAAACCCGGATCCAGAAATTCTAC
CTGAACATGCACATGAAGTACGTCCAGATGTAATCATGGCAACTGGTCGTTCGGACTACCCGAACCAAGTAAACAATGCT
TTATGTTTCCCTTATATCTTCCGTGGTGCACTTGACGTAGGTGCTACAACAATTAACGAAGATATGAAAATTGCATGTGT
ACATGCAATTGCACGTATGGCTCACGTAGAAGCTGACGCAGCTACTTATGGTGAAAAATCTGCTTCATTTGGTCGTGACT
ACTTAATTCCACGTCCACTTGATCAACGTTTGATTTTAGAAATTGCGCCTGCTGTTGCTAAAGCAGCAATGGATTCAGGT
GTTGCAACTCGTCCTATCGAAGATTTCTCTGCATATCGTCAAAAACTTTCTGAGTTTGTTTATAACTCAGCATTCTTGAT
GAAACCGATTTTTGCTCAAGCAAAAACAGATCCTAAACGTATTGCATACGCTGAAGGTGAAGATGAGCGCGTATTACGTG
CTGTTCAAATTGCAGTTGATGAAGATTTAGCTAAACCAATCTTAGTTGGTCGTACAGCAGTCATTGAAGCAAACATCAAA
AAATTAGGCTTACGTTTACAACACGGCGTAAATATCGAGATTGTAGATCAAGAACAAAATCCGTTATACGAAGAGTTCTG
GAAAGACTACTATCAAACCATGCAACGCAAAGGCATCACTGTTGAATATGCTCAACGTGAAGCTCGCCGTCGTTCAACAC
TCATTGCTGCACTTCTAGTTAAGTTTGGCAAAGCAGATGGTATGTTATGTGGTACTTACAGTAGCTATAACATTCACCTT
GACTTCGTACGCAATGTAATTGGTCTTAAAGAAGGCATGAACAACTTCTTCACGCTTAATGCATTAATGCTTGAAGATCG
CAACTTGTTTATTGCTGACACTTATGTAAACACTAATCCTACTGCTGAACAACTTGCTGAAATGACTATTTTAGCGGCTG
AAGAAGTACGTCGCTTTGGTATTACACCACGCGTAGCGCTACTTTCTCATTCAAGTTTCGGTAGTGACCAGACAGACTCA
AGCGCTCAAAAAATGCGTGAAGTTTATCGTATTTTATCTGAGCAAGCTCCAGAGCTTGAAGTTGAAGGCGAAATGCATGG
TGATGCAGCATTAGACGAAAATATTCGTCATTTTGCATTCCCTGGTTCTCGTTTCAAAGGTTCAGCGAACTTGCTGATTA
TGCCGAACTTAGATGCAGCAAATATTTCGTTCAACTTGTTAAAAGCAACTTCTGGTAACAACGTAACAATTGGTCCAATT
TTACTAGGTGCTGCTAAACCAGTTCATATTTTGACTCCGACAGCGACGACTCGCCGTCTTATCAATATGACTGCTTTAAC
TGTTGCTGAAATTCAACAGCAAGAAAAGTAA

Upstream 100 bases:

>100_bases
TTATGTTACTTGATATAATTTTGTACATAGTAAGCAGATAAATTACCAACCTTTGTGAGCAACTTGACTAGTTTGCTTTT
TTGTATCAATAGAGACTCAG

Downstream 100 bases:

>100_bases
TTTAGAAACCGCTTTTTACGAAAAGCCTTTCTAATGACTTGAGAAAACCTCTATTCTGTAGCATGATTGCTTGAAGAATA
GAGGTTTTTTCATGCAAGTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDDQSLKQAALNYHEYPNPGKISVTPSKQLVNQRDLALAYSPGVAAPCLEIERDPSAAAKYTARGNLVAVVSNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVF
HDDQHGTSIIVGSALLNALQIVNKKIEEIKIVASGAGAAALSCLDLLCALGVNKENIIVADSRGLLTTSREGLDESKKRY
VQDIKATQLHEVMAGADMFLGLSAAGILTKDMVKQMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAKAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFLMKPIFAQAKTDPKRIAYAEGEDERVLRAVQIAVDEDLAKPILVGRTAVIEANIK
KLGLRLQHGVNIEIVDQEQNPLYEEFWKDYYQTMQRKGITVEYAQREARRRSTLIAALLVKFGKADGMLCGTYSSYNIHL
DFVRNVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLAEMTILAAEEVRRFGITPRVALLSHSSFGSDQTDS
SAQKMREVYRILSEQAPELEVEGEMHGDAALDENIRHFAFPGSRFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRLINMTALTVAEIQQQEK

Sequences:

>Translated_756_residues
MDDQSLKQAALNYHEYPNPGKISVTPSKQLVNQRDLALAYSPGVAAPCLEIERDPSAAAKYTARGNLVAVVSNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVF
HDDQHGTSIIVGSALLNALQIVNKKIEEIKIVASGAGAAALSCLDLLCALGVNKENIIVADSRGLLTTSREGLDESKKRY
VQDIKATQLHEVMAGADMFLGLSAAGILTKDMVKQMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAKAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFLMKPIFAQAKTDPKRIAYAEGEDERVLRAVQIAVDEDLAKPILVGRTAVIEANIK
KLGLRLQHGVNIEIVDQEQNPLYEEFWKDYYQTMQRKGITVEYAQREARRRSTLIAALLVKFGKADGMLCGTYSSYNIHL
DFVRNVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLAEMTILAAEEVRRFGITPRVALLSHSSFGSDQTDS
SAQKMREVYRILSEQAPELEVEGEMHGDAALDENIRHFAFPGSRFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRLINMTALTVAEIQQQEK
>Mature_756_residues
MDDQSLKQAALNYHEYPNPGKISVTPSKQLVNQRDLALAYSPGVAAPCLEIERDPSAAAKYTARGNLVAVVSNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVF
HDDQHGTSIIVGSALLNALQIVNKKIEEIKIVASGAGAAALSCLDLLCALGVNKENIIVADSRGLLTTSREGLDESKKRY
VQDIKATQLHEVMAGADMFLGLSAAGILTKDMVKQMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAKAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFLMKPIFAQAKTDPKRIAYAEGEDERVLRAVQIAVDEDLAKPILVGRTAVIEANIK
KLGLRLQHGVNIEIVDQEQNPLYEEFWKDYYQTMQRKGITVEYAQREARRRSTLIAALLVKFGKADGMLCGTYSSYNIHL
DFVRNVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLAEMTILAAEEVRRFGITPRVALLSHSSFGSDQTDS
SAQKMREVYRILSEQAPELEVEGEMHGDAALDENIRHFAFPGSRFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRLINMTALTVAEIQQQEK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=405, Percent_Identity=26.4197530864197, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI62420882, Length=344, Percent_Identity=27.6162790697674, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI62420880, Length=344, Percent_Identity=27.6162790697674, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI239049447, Length=344, Percent_Identity=27.6162790697674, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1788806, Length=760, Percent_Identity=61.9736842105263, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=349, Percent_Identity=29.512893982808, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1788800, Length=327, Percent_Identity=32.7217125382263, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87081919, Length=291, Percent_Identity=25.4295532646048, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17537199, Length=453, Percent_Identity=26.4900662251656, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=30.1255230125523, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281362674, Length=472, Percent_Identity=26.271186440678, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362672, Length=472, Percent_Identity=26.271186440678, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356279, Length=472, Percent_Identity=26.271186440678, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI78707242, Length=433, Percent_Identity=24.9422632794457, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI78707238, Length=433, Percent_Identity=24.9422632794457, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646388, Length=347, Percent_Identity=27.3775216138329, Blast_Score=79, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646386, Length=347, Percent_Identity=27.3775216138329, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78707240, Length=343, Percent_Identity=25.6559766763848, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281363505, Length=345, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI78707236, Length=345, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI78707232, Length=345, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281363503, Length=345, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82814; Mature: 82814

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDQSLKQAALNYHEYPNPGKISVTPSKQLVNQRDLALAYSPGVAAPCLEIERDPSAAAK
CCCHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCCEECCCCCHHHE
YTARGNLVAVVSNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKI
EECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHH
VDIVASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTSIIVGSALLNALQ
HHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
IVNKKIEEIKIVASGAGAAALSCLDLLCALGVNKENIIVADSRGLLTTSREGLDESKKRY
HHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
VQDIKATQLHEVMAGADMFLGLSAAGILTKDMVKQMAENPIIFALANPDPEILPEHAHEV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHC
RPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADA
CCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHH
ATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAKAAMDSGVATRPIEDFSAYRQKLSEFV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YNSAFLMKPIFAQAKTDPKRIAYAEGEDERVLRAVQIAVDEDLAKPILVGRTAVIEANIK
HCCHHHHHHHHHHCCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCHH
KLGLRLQHGVNIEIVDQEQNPLYEEFWKDYYQTMQRKGITVEYAQREARRRSTLIAALLV
HHCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
KFGKADGMLCGTYSSYNIHLDFVRNVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNP
HHCCCCCEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCC
TAEQLAEMTILAAEEVRRFGITPRVALLSHSSFGSDQTDSSAQKMREVYRILSEQAPELE
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
VEGEMHGDAALDENIRHFAFPGSRFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
ECCCCCCCHHHHCCCCEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
LLGAAKPVHILTPTATTRRLINMTALTVAEIQQQEK
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDQSLKQAALNYHEYPNPGKISVTPSKQLVNQRDLALAYSPGVAAPCLEIERDPSAAAK
CCCHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCCEECCCCCHHHE
YTARGNLVAVVSNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKI
EECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHH
VDIVASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTSIIVGSALLNALQ
HHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
IVNKKIEEIKIVASGAGAAALSCLDLLCALGVNKENIIVADSRGLLTTSREGLDESKKRY
HHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
VQDIKATQLHEVMAGADMFLGLSAAGILTKDMVKQMAENPIIFALANPDPEILPEHAHEV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHC
RPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADA
CCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHH
ATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAKAAMDSGVATRPIEDFSAYRQKLSEFV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YNSAFLMKPIFAQAKTDPKRIAYAEGEDERVLRAVQIAVDEDLAKPILVGRTAVIEANIK
HCCHHHHHHHHHHCCCCCHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCHH
KLGLRLQHGVNIEIVDQEQNPLYEEFWKDYYQTMQRKGITVEYAQREARRRSTLIAALLV
HHCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
KFGKADGMLCGTYSSYNIHLDFVRNVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNP
HHCCCCCEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCC
TAEQLAEMTILAAEEVRRFGITPRVALLSHSSFGSDQTDSSAQKMREVYRILSEQAPELE
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
VEGEMHGDAALDENIRHFAFPGSRFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
ECCCCCCCHHHHCCCCEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
LLGAAKPVHILTPTATTRRLINMTALTVAEIQQQEK
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]