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The map label for this gene is ahcY [H]

Identifier: 213158055

GI number: 213158055

Start: 2834094

End: 2835476

Strand: Direct

Name: ahcY [H]

Synonym: AB57_2767

Alternate gene names: 213158055

Gene position: 2834094-2835476 (Clockwise)

Preceding gene: 213158053

Following gene: 213158056

Centisome position: 69.97

GC content: 41.65

Gene sequence:

>1383_bases
ATGAACGCGGTTAATGCTTCATTTACAGATTACAAAGTTGCTGACATCTCACTTGCTGACTACGGTCGTAAAGAAATCAA
ACTTGCTGAAGCAGAAATGCCAGCTTTGATCGGCTTACGTAAACGCTATGCAGCGTCTAAACCACTTGCTGGTGCAAAAA
TTCTTGGTTGTATCCACATGACTATTCAAACAGCGGTTCTTATTGAAACGCTTGTTGAATTAGGTGCTGAAGTTCGTTGG
ACATCTTGTAATATCTTCTCGACTCAAGACCACGCTGCTGCTGCAATTGCTGCTCGCGGTATTCCAGTTTTTGCTTGGAA
AGGTGAAACTGAAGAAGAATATGTATGGTGTCTTGAACAACAAATCAATGTAAATGGCCAACCTTGGGATGCCAACATGA
TCTTGGATGATGGCGGTGACTTAACTGCTCTTGTTCATGAAAAATATCCTGCACTTTTAGAGCGCATTCACGGTATTACC
GAAGAAACCACAACAGGTGTTCAACGTCTTATCGAAATGTGGAAAGACGGCACTTTAAAAGTACCTGCAATCAACGTAAA
TGACTCTGTTACTAAATCTAAAAACGACAACAAATATGGTTGCCGTCACTCATTAAATGACGCAATCAAACGTGCAACAG
ATATGCTTTTATCTGGCCGTCGTGCGCTTGTGATCGGTTACGGTGACGTAGGTAAAGGTTCTGCTCAATCTTTACGTCAA
GAAGGTATGATCGTTCGTGTAACTGAAGTTGACCCAATTTGTGCAATGCAAGCATGTATGGATGGTTATGAAGTTGTATC
TCCATACAAAAACGGCGTACAAACAGGTAAAAAAGAAGATATTAACCACGATCTTCTTGGCAACACTGACCTTGTTGTAA
CAACAACTGGTAACTACCACGTGTGTGATGCAGCAATGTTAGACAGCTTAAAAGCTGGTGCAGTTGTATGTAACATCGGT
CACTTCGATACAGAAATCGACACGGCTTATTTACGTGGTTACAAGTGGGTTGAAGTTAAGCCACAAGTTCACCAAGTTTA
TCGTTCAGAAGACGAAAACGATTACCTTATCCTTCTTTCTGAAGGCCGCCTTGTAAACTTAGGTAATGCAACTGGTCACC
CATCACGTGTAATGGACGGTTCTTTTGCTAACCAAGTTTTAGGTCAAATTCACTTATTCCAAGAGAAATTTGCCGACCTA
CCTGCAAGTGAAAAAGCTGCAAAAATTCGCGTAGAAGTTCTTCCTAAGAAACTTGACGAAGAGGTTGCTGCTGCAATGGT
TGCAGGTTTCGGTGGTGTACTTACTCAGTTAACTCAAGAGCAAGCTGATTATTTAGGCGTTGCTGTTGAGGGGCCATTCA
AATCTGACGCTTACAAATACTAA

Upstream 100 bases:

>100_bases
ATCATTTTGCCAGGCTCGACGATCGGTTAAACAGTCGTTTTAACCAACAACGGCATCCGCGAACAGAATGATCAATACTA
TTTTTTCCTAGGAGATCCTG

Downstream 100 bases:

>100_bases
GAACTTAAGGGCAGACGGTGAACCGACTGCCCTTTTTTCTAAAAATGTTTCGCTGTTTACAAGGATTTGACATGACTAAA
CGTACACCTATTTCTTTTGA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAASKPLAGAKILGCIHMTIQTAVLIETLVELGAEVRW
TSCNIFSTQDHAAAAIAARGIPVFAWKGETEEEYVWCLEQQINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGIT
EETTTGVQRLIEMWKDGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYHVCDAAMLDSLKAGAVVCNIG
HFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADL
PASEKAAKIRVEVLPKKLDEEVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY

Sequences:

>Translated_460_residues
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAASKPLAGAKILGCIHMTIQTAVLIETLVELGAEVRW
TSCNIFSTQDHAAAAIAARGIPVFAWKGETEEEYVWCLEQQINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGIT
EETTTGVQRLIEMWKDGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYHVCDAAMLDSLKAGAVVCNIG
HFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADL
PASEKAAKIRVEVLPKKLDEEVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY
>Mature_460_residues
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAASKPLAGAKILGCIHMTIQTAVLIETLVELGAEVRW
TSCNIFSTQDHAAAAIAARGIPVFAWKGETEEEYVWCLEQQINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGIT
EETTTGVQRLIEMWKDGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYHVCDAAMLDSLKAGAVVCNIG
HFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADL
PASEKAAKIRVEVLPKKLDEEVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=452, Percent_Identity=56.4159292035398, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI239937451, Length=430, Percent_Identity=56.046511627907, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=454, Percent_Identity=48.2378854625551, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI195539337, Length=454, Percent_Identity=48.2378854625551, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI24308043, Length=454, Percent_Identity=48.2378854625551, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI195539349, Length=454, Percent_Identity=48.2378854625551, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI21361647, Length=454, Percent_Identity=47.5770925110132, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17506425, Length=453, Percent_Identity=57.3951434878587, Blast_Score=483, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6320882, Length=467, Percent_Identity=56.1027837259101, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24642172, Length=457, Percent_Identity=57.5492341356674, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=48.3516483516484, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553387, Length=458, Percent_Identity=47.5982532751092, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553385, Length=457, Percent_Identity=47.4835886214442, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50388; Mature: 50388

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAASKPLAGAKILGCIHM
CCCCCCCCCCEEEEEEEHHHCCCCCEEEEHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
TIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIAARGIPVFAWKGETEEEYVWCLEQ
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCHHHHEEEHH
QINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGITEETTTGVQRLIEMWKDGTLK
HCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
VPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYH
CCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEE
VCDAAMLDSLKAGAVVCNIGHFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENDYLILLS
EEHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCEEEEEECHHHHHHHHCCCCCCEEEEEE
EGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADLPASEKAAKIRVEVLPKKLDE
CCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCHHHHH
EVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCC
>Mature Secondary Structure
MNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAASKPLAGAKILGCIHM
CCCCCCCCCCEEEEEEEHHHCCCCCEEEEHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
TIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIAARGIPVFAWKGETEEEYVWCLEQ
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCHHHHEEEHH
QINVNGQPWDANMILDDGGDLTALVHEKYPALLERIHGITEETTTGVQRLIEMWKDGTLK
HCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
VPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKGSAQSLRQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
EGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINHDLLGNTDLVVTTTGNYH
CCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEE
VCDAAMLDSLKAGAVVCNIGHFDTEIDTAYLRGYKWVEVKPQVHQVYRSEDENDYLILLS
EEHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCEEEEEECHHHHHHHHCCCCCCEEEEEE
EGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADLPASEKAAKIRVEVLPKKLDE
CCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCHHHHH
EVAAAMVAGFGGVLTQLTQEQADYLGVAVEGPFKSDAYKY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA