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The map label for this gene is aroP [H]

Identifier: 213157706

GI number: 213157706

Start: 3310410

End: 3311702

Strand: Direct

Name: aroP [H]

Synonym: AB57_3185

Alternate gene names: 213157706

Gene position: 3310410-3311702 (Clockwise)

Preceding gene: 213157705

Following gene: 213157708

Centisome position: 81.73

GC content: 38.75

Gene sequence:

>1293_bases
ATGGGTGGAGCAATTGGTACCGGATTATTTTTAGGCTCGGCGCAAGTGATTCAATCTGCGGGACCATCCATTATTTTAGG
ATATGCCATTGGTGGCTTAATTGCTTTTTTAATTATGCGCCACCTGGGAGAAATGATTGTTGAAGAACCTGTTGCAGGAT
CGTTCAGCCATTTTGCGTATAAATACTGGGGGAAATTTCCCGGATTTTTAGCTGGATGGAATTATTGGATGCTCTATGTT
CTGGTTGCGATGAGTGAACTCACCGCGGTAGCCAAATATATTAATTACTGGTGGCCTCATATTCCAGCATGGACGTCTGT
CTTATTTTTCTTTGTCGTGATTACGGCAATTAACCTAACAAACGTCAAATTTTATGGTGAGTCCGAATTCTGGCTCGCTA
TTATTAAAGTTGCTGCGGTTATCTCTATGATTGTTTTTGGCCTTTATTTGCTATTTACAGCAGATGTAGGTTCAAGCATT
TCATTTAGTAACCTTTGGTCTCATGGTGGATTTTTTCCAAATGGCTTTAGTGGCCTCTTCTATATGTTGGCTTTCTTGAT
GTTCGCCTTTGGTGGTATTGAACTGATTGGTATGGCCGCGGCAGAAGCAAAAGATCCGAAAAAAACCATTCCAAAAGCAA
TTAACCAAGTTGTTTTCCGTATCTTGATTTTCTATATCGGTTCACTAGCGATCTTACTTTCATTAGTGCCGTGGAACCAA
TTAGATCTAGGCGGACTCGATAAAAGTCCATTTGTTATGATTTTTAGTCAAATGGGTATTGGTTGGGCTGCACACTTACT
GAACTTTATTATTTTAACCGCCGCTCTCTCTGTTTATAACAGTGGGATGTTTGCAAATAGCCGTATGCTTTACGGTTTAG
CTCAACAAGGCAATGCACCAAAAATTTTCAAGAAAGTAAATAAACAAGGTGTACCTGTACCAGCAGTTTTGCTATCGGCA
TTACTCATTTTTGGCTGTGTTCTTTTAAATTACTTTGTACCAGAAGATGCTTTAAGCCACTTAATGTACATTGTTGTTGG
AGCACTGGTATTGAACTGGGCGATGATCAGTATGACTCACCTTAAGTTTAAATCAGCAATGAAAAAACTCGGTCAAAAAA
CTCACTTTCCTGCACTTTGGGCACCGTTTAGTAACTATTTGGTTTTAGGTTTTATTGCTGTAGTACTCTACATTATGTGG
AGTCAAGGCTTTAAAGAATCAGTGATGATGATTCCTATTTGGATCATTCTCATGTTTATTTTGTTTAAAGTACTCAATGC
CAAAGAACAGTAA

Upstream 100 bases:

>100_bases
TTAGAATAATTTACTTATTCATTGTGAGTGAAGACCTTTGACCAACGAATCTTCTACACTTCAACGAGGACTAAAAAATC
GACATATCCAATTAATTGCT

Downstream 100 bases:

>100_bases
TCTAACAGCTTGTACTTAAAACTATAAAAAGTCATTGCCTCGGCAATGGCTTTTTTGTTTATAATCAGAAAATTATGCGC
CCTTAGCTTAACTGGATAGA

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRHLGEMIVEEPVAGSFSHFAYKYWGKFPGFLAGWNYWMLYV
LVAMSELTAVAKYINYWWPHIPAWTSVLFFFVVITAINLTNVKFYGESEFWLAIIKVAAVISMIVFGLYLLFTADVGSSI
SFSNLWSHGGFFPNGFSGLFYMLAFLMFAFGGIELIGMAAAEAKDPKKTIPKAINQVVFRILIFYIGSLAILLSLVPWNQ
LDLGGLDKSPFVMIFSQMGIGWAAHLLNFIILTAALSVYNSGMFANSRMLYGLAQQGNAPKIFKKVNKQGVPVPAVLLSA
LLIFGCVLLNYFVPEDALSHLMYIVVGALVLNWAMISMTHLKFKSAMKKLGQKTHFPALWAPFSNYLVLGFIAVVLYIMW
SQGFKESVMMIPIWIILMFILFKVLNAKEQ

Sequences:

>Translated_430_residues
MGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRHLGEMIVEEPVAGSFSHFAYKYWGKFPGFLAGWNYWMLYV
LVAMSELTAVAKYINYWWPHIPAWTSVLFFFVVITAINLTNVKFYGESEFWLAIIKVAAVISMIVFGLYLLFTADVGSSI
SFSNLWSHGGFFPNGFSGLFYMLAFLMFAFGGIELIGMAAAEAKDPKKTIPKAINQVVFRILIFYIGSLAILLSLVPWNQ
LDLGGLDKSPFVMIFSQMGIGWAAHLLNFIILTAALSVYNSGMFANSRMLYGLAQQGNAPKIFKKVNKQGVPVPAVLLSA
LLIFGCVLLNYFVPEDALSHLMYIVVGALVLNWAMISMTHLKFKSAMKKLGQKTHFPALWAPFSNYLVLGFIAVVLYIMW
SQGFKESVMMIPIWIILMFILFKVLNAKEQ
>Mature_429_residues
GGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRHLGEMIVEEPVAGSFSHFAYKYWGKFPGFLAGWNYWMLYVL
VAMSELTAVAKYINYWWPHIPAWTSVLFFFVVITAINLTNVKFYGESEFWLAIIKVAAVISMIVFGLYLLFTADVGSSIS
FSNLWSHGGFFPNGFSGLFYMLAFLMFAFGGIELIGMAAAEAKDPKKTIPKAINQVVFRILIFYIGSLAILLSLVPWNQL
DLGGLDKSPFVMIFSQMGIGWAAHLLNFIILTAALSVYNSGMFANSRMLYGLAQQGNAPKIFKKVNKQGVPVPAVLLSAL
LIFGCVLLNYFVPEDALSHLMYIVVGALVLNWAMISMTHLKFKSAMKKLGQKTHFPALWAPFSNYLVLGFIAVVLYIMWS
QGFKESVMMIPIWIILMFILFKVLNAKEQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=336, Percent_Identity=26.7857142857143, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI258645169, Length=363, Percent_Identity=24.7933884297521, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI181337167, Length=348, Percent_Identity=25.8620689655172, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI258614005, Length=355, Percent_Identity=24.2253521126761, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI258614003, Length=355, Percent_Identity=24.2253521126761, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI114326544, Length=364, Percent_Identity=22.5274725274725, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI114326550, Length=364, Percent_Identity=22.5274725274725, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786302, Length=431, Percent_Identity=62.4129930394432, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=54.3123543123543, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1790653, Length=422, Percent_Identity=37.914691943128, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI48994972, Length=417, Percent_Identity=41.2470023980815, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1786602, Length=369, Percent_Identity=46.070460704607, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI87081915, Length=391, Percent_Identity=36.0613810741688, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1789017, Length=400, Percent_Identity=36, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI87081708, Length=447, Percent_Identity=34.0044742729307, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1788480, Length=373, Percent_Identity=35.1206434316354, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=361, Percent_Identity=25.207756232687, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=339, Percent_Identity=23.0088495575221, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=423, Percent_Identity=33.806146572104, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=33.175355450237, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321053, Length=435, Percent_Identity=28.9655172413793, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=460, Percent_Identity=29.3478260869565, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=428, Percent_Identity=31.7757009345794, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=380, Percent_Identity=34.4736842105263, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=459, Percent_Identity=28.7581699346405, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322892, Length=385, Percent_Identity=30.6493506493506, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=384, Percent_Identity=30.9895833333333, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=403, Percent_Identity=32.258064516129, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=408, Percent_Identity=32.3529411764706, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=382, Percent_Identity=29.5811518324607, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320251, Length=387, Percent_Identity=30.749354005168, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=389, Percent_Identity=27.5064267352185, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319608, Length=409, Percent_Identity=28.361858190709, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=389, Percent_Identity=28.0205655526992, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=389, Percent_Identity=28.7917737789203, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=486, Percent_Identity=25.1028806584362, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667468, Length=402, Percent_Identity=24.8756218905473, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666159, Length=320, Percent_Identity=24.6875, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221512776, Length=346, Percent_Identity=23.6994219653179, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077963, Length=378, Percent_Identity=25.1322751322751, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47683; Mature: 47552

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRHLGEMIVEEPVAGSFSHFAY
CCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
KYWGKFPGFLAGWNYWMLYVLVAMSELTAVAKYINYWWPHIPAWTSVLFFFVVITAINLT
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NVKFYGESEFWLAIIKVAAVISMIVFGLYLLFTADVGSSISFSNLWSHGGFFPNGFSGLF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHH
YMLAFLMFAFGGIELIGMAAAEAKDPKKTIPKAINQVVFRILIFYIGSLAILLSLVPWNQ
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LDLGGLDKSPFVMIFSQMGIGWAAHLLNFIILTAALSVYNSGMFANSRMLYGLAQQGNAP
CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCC
KIFKKVNKQGVPVPAVLLSALLIFGCVLLNYFVPEDALSHLMYIVVGALVLNWAMISMTH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKFKSAMKKLGQKTHFPALWAPFSNYLVLGFIAVVLYIMWSQGFKESVMMIPIWIILMFI
HHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LFKVLNAKEQ
HHHHHCCCCC
>Mature Secondary Structure 
GGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRHLGEMIVEEPVAGSFSHFAY
CCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
KYWGKFPGFLAGWNYWMLYVLVAMSELTAVAKYINYWWPHIPAWTSVLFFFVVITAINLT
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NVKFYGESEFWLAIIKVAAVISMIVFGLYLLFTADVGSSISFSNLWSHGGFFPNGFSGLF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHH
YMLAFLMFAFGGIELIGMAAAEAKDPKKTIPKAINQVVFRILIFYIGSLAILLSLVPWNQ
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LDLGGLDKSPFVMIFSQMGIGWAAHLLNFIILTAALSVYNSGMFANSRMLYGLAQQGNAP
CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCC
KIFKKVNKQGVPVPAVLLSALLIFGCVLLNYFVPEDALSHLMYIVVGALVLNWAMISMTH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKFKSAMKKLGQKTHFPALWAPFSNYLVLGFIAVVLYIMWSQGFKESVMMIPIWIILMFI
HHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LFKVLNAKEQ
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]