Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 213157651

GI number: 213157651

Start: 3253321

End: 3255156

Strand: Reverse

Name: sdhA [H]

Synonym: AB57_3129

Alternate gene names: 213157651

Gene position: 3255156-3253321 (Counterclockwise)

Preceding gene: 213157652

Following gene: 213157650

Centisome position: 80.36

GC content: 43.08

Gene sequence:

>1836_bases
ATGGGCGCGATAAACCCTAAAGAAGATTATTCAAATATTCAAAACCTCACTTTCGATGCTGTTATCGTTGGTGGTGGTGG
TTCTGGTATGCGTGCATCTTACCAACTTGCTCAAGCAGGTTTGAAAGTTGCAGTACTTACTAAAGTTTTCCCAACACGTT
CACATACAGTTGCTGCTCAGGGCGGTATTGGTGCGTCGTTAGGTAACATGCAAGAAGATAACTGGCATTTCCACTTTTAC
GATACAGTAAAAGGTTCTGACTGGTTAGGTGACCAAGACGCAATCGAATTTATGTGTCGTGAGGCGCCAAAAGTTGTTTA
TGAACTTGAACACTTAGGTATGCCGTTCGACCGTAACGCTGATGGTACAATTTACCAACGTCCGTTCGGTGGTCACTCTG
CAAACTATGGTGATAAGCCAGTTCCACGTGCTTGTGCTGCTGCCGACCGTACTGGTCACGCTTTATTGCACACGCTTTAT
CAAAGCAACGTGAAAATGGGTACTCAATTCTTCGTTGAGTGGATCGCTCTTGATTTGATCCGTAACGAAGCGGGTGATGT
ACTCGGTGTAACTGCAATTGACCAAGAAACTGGTAATATTGCAGTATTCCAAGCAAAAGCAACATTATTTGCAACTGGTG
GTGCTGGTCGTGTTTACCGTGCATCAACAAATGCTTATATCAACACTGGTGATGGTCTTGGTATGGCTGCTCGTGCTGGT
ATTCCATTACAAGATATGGAATTCTGGCAATTCCACCCTACAGGTGTTGCGGGCGCAGGCGTATTGTTGACTGAAGGTTG
TCGTGGTGAAGGTGCGATCCTTCGTAACAAAGACGGCGAACCATTCATGGAACGTTATGCACCAACTTTAAAAGACTTGG
CTCCGCGTGACTTCGTATCACGTTCTATGGACCAAGAAATTAAAGAAGGTCGTGGTTGTGGTCCAAAAGGTGATTATATC
TTGCTTGATATGACTCACTTGGGTGCTGACACAATTATGAAGCGTTTACCATCTGTATTTGAGATTGGTAAAAAATTCGC
AAACGTTGACATCACTAAAGAACCAATTCCAGTAGTACCAACAATCCATTATCAAATGGGTGGTATTCCTACGAATATGC
ATGGTCAAGTGTGCTTACCAGAGCCTGGTACAGACAACTACACTAAACCTGTAAAAGGTTTCTATGCAATCGGTGAGTGT
TCATGCGTATCAGTACATGGTGCGAACCGTTTAGGTACGAACTCACTTCTTGACTTGGTTGTATTTGGTAAGGCTGCTGG
TGAGCACATTATCGATTACGTAACTAAGCATCATGGTGATGAATATGCACCGCTTCCAACAAATGTATTAGAGCAAACTT
TAGCTCGTGTACGTAAATTGGATGAATCAACTTCTGGCGAAAATGCTCAAGAAGTTGCTGATGCAATTCGTGATATCGTT
CAAGACCACGCAGGTGTATTCCGTACTCAAGCATTGCTTGATAAAGGTGTTAAAGAGATTCTTGCTCTCGAACCACGCGT
GCGTAACATCCACTTGAAAGATAAATCTAAAGTATTTAACACTGCACGTGTTGAAGCGCTTGAAGTTGAAAACTTATATG
AAGTTGCAAAAGCTACATTAATTTCAGCTGCTGCGCGTAAAGAATGTCGTGGTGCGCATACGGTAGTTGATTATGAATTA
CCAGCTGATCACCCAACTTATTCATACGGTCGCCGTGATGATGAGTGGATGAAACATACTTTATGGTATTCATCAGATAA
CCGTTTGGAATATAAGCCAGTGCGCTTCAAGCCGTTAACTGTTGATCCAATTCCACCAGCACCACGTACATTCTAA

Upstream 100 bases:

>100_bases
AGGTTTACGCCTTGTACTGACTACGGCTGTCATTATTGCAGTGTTTGTGTACGCAATCTGGGGTATCCAGATTTTCTGGG
CGAATTGATAGGAAGATATC

Downstream 100 bases:

>100_bases
TCGGGAGTATAAAGATGAGTAGAGGTACTCGTACATTCGAAATCTACCGCTATGATCCTGATAAGGATAAAGCGCCGTAC
ATGCAAACTTTCAAGCTTGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFY
DTVKGSDWLGDQDAIEFMCREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLY
QSNVKMGTQFFVEWIALDLIRNEAGDVLGVTAIDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKGDYI
LLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNMHGQVCLPEPGTDNYTKPVKGFYAIGEC
SCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTNVLEQTLARVRKLDESTSGENAQEVADAIRDIV
QDHAGVFRTQALLDKGVKEILALEPRVRNIHLKDKSKVFNTARVEALEVENLYEVAKATLISAAARKECRGAHTVVDYEL
PADHPTYSYGRRDDEWMKHTLWYSSDNRLEYKPVRFKPLTVDPIPPAPRTF

Sequences:

>Translated_611_residues
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFY
DTVKGSDWLGDQDAIEFMCREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLY
QSNVKMGTQFFVEWIALDLIRNEAGDVLGVTAIDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKGDYI
LLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNMHGQVCLPEPGTDNYTKPVKGFYAIGEC
SCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTNVLEQTLARVRKLDESTSGENAQEVADAIRDIV
QDHAGVFRTQALLDKGVKEILALEPRVRNIHLKDKSKVFNTARVEALEVENLYEVAKATLISAAARKECRGAHTVVDYEL
PADHPTYSYGRRDDEWMKHTLWYSSDNRLEYKPVRFKPLTVDPIPPAPRTF
>Mature_610_residues
GAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFYD
TVKGSDWLGDQDAIEFMCREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQ
SNVKMGTQFFVEWIALDLIRNEAGDVLGVTAIDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAGI
PLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKGDYIL
LDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNMHGQVCLPEPGTDNYTKPVKGFYAIGECS
CVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTNVLEQTLARVRKLDESTSGENAQEVADAIRDIVQ
DHAGVFRTQALLDKGVKEILALEPRVRNIHLKDKSKVFNTARVEALEVENLYEVAKATLISAAARKECRGAHTVVDYELP
ADHPTYSYGRRDDEWMKHTLWYSSDNRLEYKPVRFKPLTVDPIPPAPRTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=591, Percent_Identity=50.761421319797, Blast_Score=566, Evalue=1e-161,
Organism=Escherichia coli, GI1786942, Length=596, Percent_Identity=52.5167785234899, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1790597, Length=588, Percent_Identity=39.6258503401361, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=32.9136690647482, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17505833, Length=614, Percent_Identity=49.6742671009772, Blast_Score=546, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17550100, Length=591, Percent_Identity=49.5769881556684, Blast_Score=545, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=50.1666666666667, Blast_Score=574, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322416, Length=605, Percent_Identity=50.0826446280992, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI17137288, Length=611, Percent_Identity=49.4271685761047, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24655642, Length=611, Percent_Identity=49.4271685761047, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24655647, Length=611, Percent_Identity=49.4271685761047, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24663005, Length=622, Percent_Identity=45.4983922829582, Blast_Score=519, Evalue=1e-147,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66998; Mature: 66866

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQ
CCCCCCHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHCCCCCCEEEEC
GGIGASLGNMQEDNWHFHFYDTVKGSDWLGDQDAIEFMCREAPKVVYELEHLGMPFDRNA
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQSNVKMGTQFFVEWIALDLI
CCCEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RNEAGDVLGVTAIDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
HCCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCHHHCC
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVS
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHHCCHHHHCCCHHHHH
RSMDQEIKEGRGCGPKGDYILLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVP
HHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCE
TIHYQMGGIPTNMHGQVCLPEPGTDNYTKPVKGFYAIGECSCVSVHGANRLGTNSLLDLV
EEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHH
VFGKAAGEHIIDYVTKHHGDEYAPLPTNVLEQTLARVRKLDESTSGENAQEVADAIRDIV
HHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QDHAGVFRTQALLDKGVKEILALEPRVRNIHLKDKSKVFNTARVEALEVENLYEVAKATL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHEEHHHHHHHHHHHHHH
ISAAARKECRGAHTVVDYELPADHPTYSYGRRDDEWMKHTLWYSSDNRLEYKPVRFKPLT
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHEEECCCCCEEECCEEEECEE
VDPIPPAPRTF
ECCCCCCCCCC
>Mature Secondary Structure 
GAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQ
CCCCCHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHCCCCCCEEEEC
GGIGASLGNMQEDNWHFHFYDTVKGSDWLGDQDAIEFMCREAPKVVYELEHLGMPFDRNA
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQSNVKMGTQFFVEWIALDLI
CCCEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RNEAGDVLGVTAIDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
HCCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCHHHCC
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVS
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHHCCHHHHCCCHHHHH
RSMDQEIKEGRGCGPKGDYILLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVP
HHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCE
TIHYQMGGIPTNMHGQVCLPEPGTDNYTKPVKGFYAIGECSCVSVHGANRLGTNSLLDLV
EEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHH
VFGKAAGEHIIDYVTKHHGDEYAPLPTNVLEQTLARVRKLDESTSGENAQEVADAIRDIV
HHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QDHAGVFRTQALLDKGVKEILALEPRVRNIHLKDKSKVFNTARVEALEVENLYEVAKATL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHEEHHHHHHHHHHHHHH
ISAAARKECRGAHTVVDYELPADHPTYSYGRRDDEWMKHTLWYSSDNRLEYKPVRFKPLT
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHEEECCCCCEEECCEEEECEE
VDPIPPAPRTF
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]