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The map label for this gene is grxD [H]

Identifier: 213157582

GI number: 213157582

Start: 2359362

End: 2359703

Strand: Direct

Name: grxD [H]

Synonym: AB57_2275

Alternate gene names: 213157582

Gene position: 2359362-2359703 (Clockwise)

Preceding gene: 213157580

Following gene: 213157584

Centisome position: 58.25

GC content: 41.81

Gene sequence:

>342_bases
ATGACTGAACAAGCACGTGATACTGAAGCGTTAATTCGCGATCAAATTGCGAAGCATCCCGTTTTACTTTACATGAAAGG
CACTCCACAGTTTCCACAATGTGGTTTCTCTGCACGTGCAGTAGAGGCGCTCAGTCAAATTGGTCGTCCATTTGCATATG
TGAACATCTTAGAAAACCCTGATATTCGTGCAACTTTACCAAAAATTGCAAACTGGCCTACTTTTCCACAATTATGGGTA
AACGGCGAGCTTATTGGTGGTAGCGATATCATGCTTGAAATGTTCCAAAATGGCGAATTAAAACCATTAATCGAACAATA
CAGCGCAGCTCCAGAAGCTTAA

Upstream 100 bases:

>100_bases
TAAAATATTGAATATTCTGTGCAACTTTAAGCAACAAGGCGGTTTGCAAAGCGATGTGAACACCCCCTATAATGCTGCAA
GATTAGTTGAGGATCTATTT

Downstream 100 bases:

>100_bases
TAATAAAAAAGCCAATCAAAAGATTGGCTTTTTTATACTTATAAATTTAACAATCACTTATACCGACATAACGAAATAGT
CCATCTACACCAAGATCTGC

Product: glutaredoxin-related protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MTEQARDTEALIRDQIAKHPVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPKIANWPTFPQLWV
NGELIGGSDIMLEMFQNGELKPLIEQYSAAPEA

Sequences:

>Translated_113_residues
MTEQARDTEALIRDQIAKHPVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPKIANWPTFPQLWV
NGELIGGSDIMLEMFQNGELKPLIEQYSAAPEA
>Mature_112_residues
TEQARDTEALIRDQIAKHPVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPKIANWPTFPQLWVN
GELIGGSDIMLEMFQNGELKPLIEQYSAAPEA

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=46.5116279069767, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI95113651, Length=87, Percent_Identity=45.9770114942529, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787943, Length=98, Percent_Identity=66.3265306122449, Blast_Score=148, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71988153, Length=85, Percent_Identity=37.6470588235294, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17556042, Length=91, Percent_Identity=35.1648351648352, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988159, Length=82, Percent_Identity=40.2439024390244, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325198, Length=101, Percent_Identity=45.5445544554455, Blast_Score=99, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321022, Length=74, Percent_Identity=47.2972972972973, Blast_Score=84, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320303, Length=77, Percent_Identity=45.4545454545455, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24642023, Length=85, Percent_Identity=38.8235294117647, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19921242, Length=97, Percent_Identity=35.0515463917526, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12630; Mature: 12498

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQARDTEALIRDQIAKHPVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENP
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCC
DIRATLPKIANWPTFPQLWVNGELIGGSDIMLEMFQNGELKPLIEQYSAAPEA
CCEEECCHHCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
TEQARDTEALIRDQIAKHPVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENP
CCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCC
DIRATLPKIANWPTFPQLWVNGELIGGSDIMLEMFQNGELKPLIEQYSAAPEA
CCEEECCHHCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]