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The map label for this gene is clpA [H]

Identifier: 213157553

GI number: 213157553

Start: 2328430

End: 2330706

Strand: Reverse

Name: clpA [H]

Synonym: AB57_2244

Alternate gene names: 213157553

Gene position: 2330706-2328430 (Counterclockwise)

Preceding gene: 213157554

Following gene: 213157552

Centisome position: 57.54

GC content: 40.1

Gene sequence:

>2277_bases
ATGCTCAGTCGTCAATTAGAAGTATCATTACGTTTGGCTGTTAGCATGGCTCGTCAAAAGAGACATGAGTTTCTTACAGT
TGAACATTTACTATTAGCCTTACTCGATAACGATTCGGCTGTGAATGCATTAAAAGCATGCGGAGCTGATATTGTTTCTT
TACGTAAAGAATTAGAAGAATATGTAGAACAACATACTCCTAAGCTTGGCGAAAATAGCGAGCAAGCTCCACATCCAACA
GAAAGTTTCGACCGCATTTTGCAACGTGCAATTTTCCACGTTCAATCAAGTGGTGGTGACCGTACTGTTGAAGGTGCGGA
TGTTTTAGTCGCAATGTATTCAGAGCGTGATTCTTTTGCTGTTTATCTGCTTAAACGTCATCAAATTAATCGATTGACTT
TAACTCAATACTTGTCTCATGGGACACGTAAAGACGAAGTTCAGGTTGAAGAAGAAGTTGAAGACATTGAGGGTGAAAGC
AATTCAGGCAATGCCGGACCATTAGAACTTTATACGCTCAATTTAAATGTTGAAGCGCAAAAAGGTAAAACTGATCCACT
CATTGGTCGTGAGAAAGAAATTGAGCGTACAGCACAAATTCTTTGCCGTCGTCGTAAAAACAATCCATTGTTGGTAGGCG
ACCCGGGTGTAGGTAAAACTTCAATTGCAGAAGGCCTTGCATGGCTTATTGTAAATGGTAAAGCACCAAAACCGCTAAGC
CATGCAGAAATTTACAGCCTTGATATTGGTGCATTGGTTGCGGGTACAAAATATCGTGGTGACTTTGAAAAACGTTTAAA
ACAATTGTTAAACGCTTTGAAGAAAAATCCGAATGCGATTTTATTCATTGATGAAATTCATATGATCATTGGTGCAGGCT
CAAGTATGGGCAGTACGATGGATGCTTCGAATCTCATTAAACCAGCTTTAGCAAATGGTACTTTACGCTGCATTGGATCA
ACAACGTTCCAAGAATATCGTCAGGTATTTGAAAAGGATCATGCGTTATCTCGTCGTTTCCAAAAAATTGACGTAAATGA
ACCGAGCATTTCTGAAACTATTGATATTTTACGTGGCTTGAAAACGAAGTTTGAAGATTTCCACCATGTACAGTATGACG
ACAAAGCTTTGGTTTCTGCGGTTGAGCTTTCTGCGAAATTTATTAATGATCGTTTCTTGCCAGATAAAGCGATTGATGTC
ATTGATGAAGCAGGTGCACAGCGCCGTTTAAAAGCAGAAAGTGAAGACAGCTTAATTACTGTAGAAAACATCGAAGATAT
TGTTTCTAAGATTGCGCGTATTCCGCCTAAAACTGTATCTAAAGATGATAAATCTGTACTTGAAAATCTTGAGCGTGACC
TAAAACGTGTTGTATTTGGTCAAGATGAAGCAATTACTGCACTAGCTTCTGCAATCAAGTTGTCACGTGCTGGTTTGAAA
TCGCCAGATAAACCAGTTGGTAGCTTTGTGTTTGCTGGTCCTACCGGTGTAGGTAAAACTGAGGTTACGAAGCAATTAGC
AAAACTTTTAGGTGTAGAGCTTGTTCGTTTCGATATGTCTGAGTATATGGAGCGTCATGCTGTTTCTCGCTTAATTGGTG
CTCCTCCAGGGTATGTGGGTTATGACCAAGGTGGCTTACTCACAGATGCGATTCATAAAAATCCACACTGTGTATTGTTA
CTGGATGAAATTGAGAAAGCACATCCTGATGTGTTTAACCTGTTATTACAAATCATGGATCATGGTGCATTAACAGACAA
TAATGGTCGTAAGTCAGACTTTAGAAATGTCATTATTGTGTTGACGACGAACATTGGTGCAGAAAGTATTTCTCGTGCAA
GCATTGGATTTACAGAGCAAGACCATAGTTCGGACAACCAAGAAGCCATGAAACGTGCATTCTCACCTGAATTCCGTAAC
CGTCTAGATGGTGTTATTCAATTCAAAGCTTTACCAACCACAGTGATTGAATCTGTAGTTGATAAGTTCTTGACAGAATT
GCAAGCGCAGCTAGATGAAAAACGCGTAGTTTTAGATGTCGATCAAAGTGCACGCGACTGGTTAGCGACAAATGGTTATG
ATCGTTTAATGGGCGCTCGACCAATGCAACGACTCATTCAAGAACACTTGAAGAAACCATTAGCTGAAATGATACTGTTT
GGTGAACTTGCAGATCATGGCGGTAATGTGGCGGTATCAGTGAAGAAAGAAGATGGTAAAGCAGTGGGTCTAAAACTTGA
AGTGTTTGAAGACCACCATACGGCAGAACCAGCTTAA

Upstream 100 bases:

>100_bases
AGACATCGCGGAAACCAAGGCAAACCTTGTTAATAATTACGCTCGATCGCAAGGTCATCCATTACTTTGCCAGATTGAGC
CTAAAGCATAAGGGGGTCAC

Downstream 100 bases:

>100_bases
TTTATGTTAATTGATAGTCTTTCTATAACCCGAATATTTAGTGTGTTCGGGTTATTTATTATTACTGCAATCGCTGAGAT
TTTGGGTTGTTACTTTCCTT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEEYVEQHTPKLGENSEQAPHPT
ESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFAVYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGES
NSGNAGPLELYTLNLNVEAQKGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLS
HAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTMDASNLIKPALANGTLRCIGS
TTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGLKTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDV
IDEAGAQRRLKAESEDSLITVENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLK
SPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVGYDQGGLLTDAIHKNPHCVLL
LDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIVLTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRN
RLDGVIQFKALPTTVIESVVDKFLTELQAQLDEKRVVLDVDQSARDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILF
GELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA

Sequences:

>Translated_758_residues
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEEYVEQHTPKLGENSEQAPHPT
ESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFAVYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGES
NSGNAGPLELYTLNLNVEAQKGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLS
HAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTMDASNLIKPALANGTLRCIGS
TTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGLKTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDV
IDEAGAQRRLKAESEDSLITVENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLK
SPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVGYDQGGLLTDAIHKNPHCVLL
LDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIVLTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRN
RLDGVIQFKALPTTVIESVVDKFLTELQAQLDEKRVVLDVDQSARDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILF
GELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA
>Mature_758_residues
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEEYVEQHTPKLGENSEQAPHPT
ESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFAVYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGES
NSGNAGPLELYTLNLNVEAQKGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLS
HAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTMDASNLIKPALANGTLRCIGS
TTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGLKTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDV
IDEAGAQRRLKAESEDSLITVENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLK
SPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVGYDQGGLLTDAIHKNPHCVLL
LDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIVLTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRN
RLDGVIQFKALPTTVIESVVDKFLTELQAQLDEKRVVLDVDQSARDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILF
GELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=175, Percent_Identity=39.4285714285714, Blast_Score=152, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=740, Percent_Identity=62.027027027027, Blast_Score=930, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=417, Percent_Identity=43.4052757793765, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=324, Percent_Identity=47.8395061728395, Blast_Score=297, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6323002, Length=408, Percent_Identity=37.0098039215686, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84128; Mature: 84128

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
YVEQHTPKLGENSEQAPHPTESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCEE
VYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGESNSGNAGPLELYTLNLNVEAQ
EEEHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC
KGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLS
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCEEEEEECCCCCCCCC
HAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTM
CCCEEEEEHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCCC
DASNLIKPALANGTLRCIGSTTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGL
CHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDVIDEAGAQRRLKAESEDSLIT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCEEE
VENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YDQGGLLTDAIHKNPHCVLLLDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIV
CCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
LTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRNRLDGVIQFKALPTTVIESVV
EEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCEEEEECCCHHHHHHHH
DKFLTELQAQLDEKRVVLDVDQSARDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILF
HHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA
HHHHCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
YVEQHTPKLGENSEQAPHPTESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCEE
VYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGESNSGNAGPLELYTLNLNVEAQ
EEEHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC
KGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLS
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCEEEEEECCCCCCCCC
HAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTM
CCCEEEEEHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCCC
DASNLIKPALANGTLRCIGSTTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGL
CHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDVIDEAGAQRRLKAESEDSLIT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCEEE
VENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YDQGGLLTDAIHKNPHCVLLLDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIV
CCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
LTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRNRLDGVIQFKALPTTVIESVV
EEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCEEEEECCCHHHHHHHH
DKFLTELQAQLDEKRVVLDVDQSARDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILF
HHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA
HHHHCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]