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The map label for this gene is ethA [H]

Identifier: 213157389

GI number: 213157389

Start: 2155166

End: 2156698

Strand: Direct

Name: ethA [H]

Synonym: AB57_2078

Alternate gene names: 213157389

Gene position: 2155166-2156698 (Clockwise)

Preceding gene: 213157384

Following gene: 213157390

Centisome position: 53.21

GC content: 36.79

Gene sequence:

>1533_bases
ATGAATACATCAGAACAAGTTACTACTACTGATGTTTTAATCATTGGCGCAGGGATTGCAGGTATTAGTGCAGCCTATCA
CCTAAAAAAACATCGACCAAATACTACATTTATTATTCTAGAAGCCCGAGATACATTTGGTGGCACATGGAGTCAATTTA
AATATCCAGGGATTCGATCTGACTCAGACATGCCCTCTTTTGGATTCGGCTTTAAACCTTGGACCCATCAAAAAGCAATT
GCCCAAGCAAATGTGATTTGTGACTATCTACAAGAAACTATTCAAGAAAATAAAATAAATGCTCATATTAACTATGGCTA
TAAAGTCAATAAGGCTGAATTTTCATCAGATGAACAGCTTTGGACCATCACGGCTGAAAATCTAGCATCAAAAGCATTAG
TAAATTTTAAAGCCCGCTTTTTACTATTAAATACAGGCTATTATGATTACCAAAAGGGCTTTACTCCAGAATTTGAGGGG
ATTGAGTCTTTTAAAGGAAAGGTTATTCATCCTCAACACTGGCCAGTAGGTTTTGATTACACTAAAAAACGTGTAATCGT
TATTGGTAGTGGAGCCACAGCTGTAACTCTACTGCCTTCTATGGCGGATAAAGCAGAACATGTAACTATGCTTCAGCGGT
CACCAACTTATATGGTTTCTTTTCCCGCTGTTGATCCAATTGCAGGTATGTTGAATAAAATTTTAGGCTATGAAAGAGCT
TATCCGATTATTCGCAAAAAAAATATTTCAATGAACCGTGCATTATATAAAGCTTGTCGTAACTATCCGCAAATTATGAA
GAAGCTATTAATTGCAGATGTGCGACGAAGACTTCCAAAGGGTTTTGATGTAGAAACACATTTTACGCCTAAATATAACC
CGTGGGATGAACGTTTATGCTTAGTTCCTGATGGAGACCTATTCAAATCCATTTCTGAAGGTAAAGCTTCCGTTGTTACG
GATCGTATTAAGAAATTCACAGAAAATGGTATTTTATTAGAATCTGGAAAATTGCTCGAAGCTGATGTTATTGTCACTGC
TACAGGTTTAAATATGTTGGCCTTTAGCCGTATTCAGCTCACAGTAGATGACAAAAATATTCAATATCCAGATACCACTA
TTTTCAAGTCAATGATGCTTTCTGACGTACCGAATCTAGCATTTGCATTTGGTTATACCAATATCGCATGGACATTAAAA
GTTGATCTTGTTTGGGAACATTTTTGTCGTATGCTTGACTATATGGATGAAAATGGCTACGGCACATTCAAACCTTTTAT
CCAAAACAAAAAAATGGAACGAGTACCCTTCATTGATTTAAGCCCAGGCTATGTACAACGTGGTCTAGCACAATTTCCAA
AAGCTGGAACAGAAGGACCTTGGACATTACAACATGCCTATGAGCATGATTTTGAAAGACTTCGTAAGGGTCCTGTTAAT
GATCCTGAGTTGCTCTTCATAAAGCGGTTATCGAAAAAAAAACTATCTGTAATGAATGAGCCTTCAACTAAGCAAATTAA
AGCACAAGCTTAA

Upstream 100 bases:

>100_bases
ATCAGTTCCATGGATCAGGAAAAATGAAGATTAATAAATTCATCATCTTAGAAAATCTAACTGATGCTTAACTACTGAAA
TTTGTAGAGAGGAATACGAT

Downstream 100 bases:

>100_bases
TTTTCAACTTTCTTGATCTCTTATTTGAAAAGGCTATCGAAATGGGAGATTTAAGATCGATAAATCGAGATTCTTATGCA
AGATATTAAATTCATAAGTC

Product: flavin binding monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNTSEQVTTTDVLIIGAGIAGISAAYHLKKHRPNTTFIILEARDTFGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHQKAI
AQANVICDYLQETIQENKINAHINYGYKVNKAEFSSDEQLWTITAENLASKALVNFKARFLLLNTGYYDYQKGFTPEFEG
IESFKGKVIHPQHWPVGFDYTKKRVIVIGSGATAVTLLPSMADKAEHVTMLQRSPTYMVSFPAVDPIAGMLNKILGYERA
YPIIRKKNISMNRALYKACRNYPQIMKKLLIADVRRRLPKGFDVETHFTPKYNPWDERLCLVPDGDLFKSISEGKASVVT
DRIKKFTENGILLESGKLLEADVIVTATGLNMLAFSRIQLTVDDKNIQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLK
VDLVWEHFCRMLDYMDENGYGTFKPFIQNKKMERVPFIDLSPGYVQRGLAQFPKAGTEGPWTLQHAYEHDFERLRKGPVN
DPELLFIKRLSKKKLSVMNEPSTKQIKAQA

Sequences:

>Translated_510_residues
MNTSEQVTTTDVLIIGAGIAGISAAYHLKKHRPNTTFIILEARDTFGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHQKAI
AQANVICDYLQETIQENKINAHINYGYKVNKAEFSSDEQLWTITAENLASKALVNFKARFLLLNTGYYDYQKGFTPEFEG
IESFKGKVIHPQHWPVGFDYTKKRVIVIGSGATAVTLLPSMADKAEHVTMLQRSPTYMVSFPAVDPIAGMLNKILGYERA
YPIIRKKNISMNRALYKACRNYPQIMKKLLIADVRRRLPKGFDVETHFTPKYNPWDERLCLVPDGDLFKSISEGKASVVT
DRIKKFTENGILLESGKLLEADVIVTATGLNMLAFSRIQLTVDDKNIQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLK
VDLVWEHFCRMLDYMDENGYGTFKPFIQNKKMERVPFIDLSPGYVQRGLAQFPKAGTEGPWTLQHAYEHDFERLRKGPVN
DPELLFIKRLSKKKLSVMNEPSTKQIKAQA
>Mature_510_residues
MNTSEQVTTTDVLIIGAGIAGISAAYHLKKHRPNTTFIILEARDTFGGTWSQFKYPGIRSDSDMPSFGFGFKPWTHQKAI
AQANVICDYLQETIQENKINAHINYGYKVNKAEFSSDEQLWTITAENLASKALVNFKARFLLLNTGYYDYQKGFTPEFEG
IESFKGKVIHPQHWPVGFDYTKKRVIVIGSGATAVTLLPSMADKAEHVTMLQRSPTYMVSFPAVDPIAGMLNKILGYERA
YPIIRKKNISMNRALYKACRNYPQIMKKLLIADVRRRLPKGFDVETHFTPKYNPWDERLCLVPDGDLFKSISEGKASVVT
DRIKKFTENGILLESGKLLEADVIVTATGLNMLAFSRIQLTVDDKNIQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLK
VDLVWEHFCRMLDYMDENGYGTFKPFIQNKKMERVPFIDLSPGYVQRGLAQFPKAGTEGPWTLQHAYEHDFERLRKGPVN
DPELLFIKRLSKKKLSVMNEPSTKQIKAQA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI193202226, Length=227, Percent_Identity=25.1101321585903, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57988; Mature: 57988

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSEQVTTTDVLIIGAGIAGISAAYHLKKHRPNTTFIILEARDTFGGTWSQFKYPGIRS
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCC
DSDMPSFGFGFKPWTHQKAIAQANVICDYLQETIQENKINAHINYGYKVNKAEFSSDEQL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCEE
WTITAENLASKALVNFKARFLLLNTGYYDYQKGFTPEFEGIESFKGKVIHPQHWPVGFDY
EEEEHHHHHHHHHHCEEEEEEEEECCCCHHCCCCCCCCCCHHHHCCCEECCCCCCCCCCC
TKKRVIVIGSGATAVTLLPSMADKAEHVTMLQRSPTYMVSFPAVDPIAGMLNKILGYERA
CCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCHHHC
YPIIRKKNISMNRALYKACRNYPQIMKKLLIADVRRRLPKGFDVETHFTPKYNPWDERLC
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHCEEE
LVPDGDLFKSISEGKASVVTDRIKKFTENGILLESGKLLEADVIVTATGLNMLAFSRIQL
ECCCCHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCEEEEEEEEE
TVDDKNIQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLKVDLVWEHFCRMLDYMDENGY
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCC
GTFKPFIQNKKMERVPFIDLSPGYVQRGLAQFPKAGTEGPWTLQHAYEHDFERLRKGPVN
CCCHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCC
DPELLFIKRLSKKKLSVMNEPSTKQIKAQA
CCHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure
MNTSEQVTTTDVLIIGAGIAGISAAYHLKKHRPNTTFIILEARDTFGGTWSQFKYPGIRS
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCC
DSDMPSFGFGFKPWTHQKAIAQANVICDYLQETIQENKINAHINYGYKVNKAEFSSDEQL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCEE
WTITAENLASKALVNFKARFLLLNTGYYDYQKGFTPEFEGIESFKGKVIHPQHWPVGFDY
EEEEHHHHHHHHHHCEEEEEEEEECCCCHHCCCCCCCCCCHHHHCCCEECCCCCCCCCCC
TKKRVIVIGSGATAVTLLPSMADKAEHVTMLQRSPTYMVSFPAVDPIAGMLNKILGYERA
CCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCHHHC
YPIIRKKNISMNRALYKACRNYPQIMKKLLIADVRRRLPKGFDVETHFTPKYNPWDERLC
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHCEEE
LVPDGDLFKSISEGKASVVTDRIKKFTENGILLESGKLLEADVIVTATGLNMLAFSRIQL
ECCCCHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEEECCCCEEEEEEEEE
TVDDKNIQYPDTTIFKSMMLSDVPNLAFAFGYTNIAWTLKVDLVWEHFCRMLDYMDENGY
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCC
GTFKPFIQNKKMERVPFIDLSPGYVQRGLAQFPKAGTEGPWTLQHAYEHDFERLRKGPVN
CCCHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCC
DPELLFIKRLSKKKLSVMNEPSTKQIKAQA
CCHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA