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The map label for this gene is prlC [H]

Identifier: 213157151

GI number: 213157151

Start: 1920654

End: 1922666

Strand: Direct

Name: prlC [H]

Synonym: AB57_1834

Alternate gene names: 213157151

Gene position: 1920654-1922666 (Clockwise)

Preceding gene: 213157150

Following gene: 213157152

Centisome position: 47.42

GC content: 39.54

Gene sequence:

>2013_bases
ATGAAAAATAATACACTGAAAATGACTACATTATGTATGTTGACCATAGGTATAAGTCAATTTGCATCGGCTGAAGCGAC
GCGTGCGACATTACCATTACTCAAAGCAGAGCAACTCCCAGCATGGTGTGATTCTAATTTAAAAAAAATTCAGCAAGAAA
TTTCTAGTTTTGAAAAAACGCCTGTTAAAAACGATGCTGCCGCTGCTCCGATATTAGCCAAGTGGGATAAAATTTTTGGT
CATCTTGAAGATTTTTCGGGACCCATAGGTCTATATAGTAATGTAGACCCAGATGCGAAATTACGTAAGGCAGCAGAAGA
CTGCGAAATCAAAATTAATCAATTTCATACGGATATATTCCAAAACTCCAAACTGTATAACGTAATTAAAAATACAAAAG
CGACTGATCCGATTGACCAGAAATACCGTCAAGATATTCTGGATCAATTTGAAGACACAGGGGTTCAGCTAGAACCAGCA
AAACGCGCAAGAATGAAGGCTATTCTGGATGAGTTGACTAAACTCGAACAAGAATATAACCGTAATATTCGTGATAACCC
GGAAAAACTTGAATTTACTCCTGAAGAGATGAAAGGCTTACCCGAAAGTTATATTTCGGGATTAAAGAAAAATACGAAAG
GTAACTATCTATTAGGTTTTGAGTATCCGGAATATCGTCCATTTATGGAGCTAGCGGATAATGATGATGCCCGAAAAAGA
TATCAAATTGCCTTTACACGACGTGGGACTGAACAAAATTTAAAACTACTCAAACAGGCAATAGATTTACGTTATGAACT
TGCACAGTTATTTGGAAAAGCGAGTTATGCAGATTGGGCTTTAAAAGACCGAATGGCAAAAACACCAGAGGCTGTAAACA
AGTTCTTGGCAGAAGTACAAAAAACTGTAGCACCACTTGAACGTAAAGAAGTAGAAGAACTTCGCGCCTTTAAAGCACAA
ACCTTAAAAACGCCGTTAGACAAAACCGAGATAACGCGTTGGAGTGAAGCTTACTGGAGCGAAAAACTTCGTAAGAGTAA
ATATCAAATTGATCAGGAAAAGCTTCGTGATTATTTTCCGACTTTAGCCGCACAAAAATGGTTATTTGCTATTTCATCTG
ACCTTTACGGTATTGATTTTAAACCTGTCAAAGTTAAAGCATGGCAGGATGAAGTTGAATATTACGATGTAGTTGATAAA
AAGACAGGTAAACTCCTTGGTGGCTTATATATGGATAAATTCCCTCGTGAAGGGAAATATGGCCATGCAGCAGTTTGGGG
AGTATATGGTGGCAGCACTTTAACCAACCGATTACCGATTTCAGTATTGGTGACCAACTTTAACCGTAAAGGTTTAAATA
GTGATGAGCTTGAAACTTTTGTTCATGAGTTCGGTCATGCTTTACATGGCATCTTATCAAACACACGCTATGCCAGTCAG
TCCGGAACCTCTGTAGAGCGCGATTTTGTAGAAGCACCTTCTCAAATGTATGAAGAGTGGGCACGCCGTAAAGAGACTTT
ATCTAAAGTGGCTGATTATTGTGATCCAGCATGCCCACAAGTTGATGATGAATTAATTGCCCGTTTAAAAGCAGTACATA
ACTATGGCCGTGGCTTGCGTTATGCCCGTCAGACGCTTTATGCACAATATGACATGGCACTTCATACGGCAGATGCCTTA
AAAGTAAAACCTTTAGAAACTTGGCAAAAAATGGAAGCTGTTACAGCCTTAGGATATGTGCCAACAACTGAATTCCCCGG
GCAATTCGGGCATTTAATGGGTGGTTATCAGGCAGGTTATTACGGTTATATGTGGTCTGAGGTTTTAGCGCTAGACATGC
TTTCTGCTTATGGTGACAACCTGAACAACCCACAAGTGGGACAACGTTATCGTCAGACGATTTTATCGCAGGGTAGCCAA
AAACCGGCAGCTGAATTGGTTAAAGATTTCCTTGGTCGTGATCCTGACAATAAAGCATTCTTTAACGAAATTACCGGACA
ACGGGTTAAATAA

Upstream 100 bases:

>100_bases
TGGATATAAGAAGCATCCGATTTTACATGCTGAATGGATGTACTTCGATATTGATACAAATATGAAATCTAATCATTAAA
TGAAAAAAATTGGAGATACG

Downstream 100 bases:

>100_bases
GGAATTATCACTATGCTGGCATATGTTATTCGGCGTTTATGGCAGATGATTCCGACCATGTTGGGAGTAGTGCTGCTTAT
TTTTATCTTATTTAATTGGG

Product: Zn-dependent oligopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MKNNTLKMTTLCMLTIGISQFASAEATRATLPLLKAEQLPAWCDSNLKKIQQEISSFEKTPVKNDAAAAPILAKWDKIFG
HLEDFSGPIGLYSNVDPDAKLRKAAEDCEIKINQFHTDIFQNSKLYNVIKNTKATDPIDQKYRQDILDQFEDTGVQLEPA
KRARMKAILDELTKLEQEYNRNIRDNPEKLEFTPEEMKGLPESYISGLKKNTKGNYLLGFEYPEYRPFMELADNDDARKR
YQIAFTRRGTEQNLKLLKQAIDLRYELAQLFGKASYADWALKDRMAKTPEAVNKFLAEVQKTVAPLERKEVEELRAFKAQ
TLKTPLDKTEITRWSEAYWSEKLRKSKYQIDQEKLRDYFPTLAAQKWLFAISSDLYGIDFKPVKVKAWQDEVEYYDVVDK
KTGKLLGGLYMDKFPREGKYGHAAVWGVYGGSTLTNRLPISVLVTNFNRKGLNSDELETFVHEFGHALHGILSNTRYASQ
SGTSVERDFVEAPSQMYEEWARRKETLSKVADYCDPACPQVDDELIARLKAVHNYGRGLRYARQTLYAQYDMALHTADAL
KVKPLETWQKMEAVTALGYVPTTEFPGQFGHLMGGYQAGYYGYMWSEVLALDMLSAYGDNLNNPQVGQRYRQTILSQGSQ
KPAAELVKDFLGRDPDNKAFFNEITGQRVK

Sequences:

>Translated_670_residues
MKNNTLKMTTLCMLTIGISQFASAEATRATLPLLKAEQLPAWCDSNLKKIQQEISSFEKTPVKNDAAAAPILAKWDKIFG
HLEDFSGPIGLYSNVDPDAKLRKAAEDCEIKINQFHTDIFQNSKLYNVIKNTKATDPIDQKYRQDILDQFEDTGVQLEPA
KRARMKAILDELTKLEQEYNRNIRDNPEKLEFTPEEMKGLPESYISGLKKNTKGNYLLGFEYPEYRPFMELADNDDARKR
YQIAFTRRGTEQNLKLLKQAIDLRYELAQLFGKASYADWALKDRMAKTPEAVNKFLAEVQKTVAPLERKEVEELRAFKAQ
TLKTPLDKTEITRWSEAYWSEKLRKSKYQIDQEKLRDYFPTLAAQKWLFAISSDLYGIDFKPVKVKAWQDEVEYYDVVDK
KTGKLLGGLYMDKFPREGKYGHAAVWGVYGGSTLTNRLPISVLVTNFNRKGLNSDELETFVHEFGHALHGILSNTRYASQ
SGTSVERDFVEAPSQMYEEWARRKETLSKVADYCDPACPQVDDELIARLKAVHNYGRGLRYARQTLYAQYDMALHTADAL
KVKPLETWQKMEAVTALGYVPTTEFPGQFGHLMGGYQAGYYGYMWSEVLALDMLSAYGDNLNNPQVGQRYRQTILSQGSQ
KPAAELVKDFLGRDPDNKAFFNEITGQRVK
>Mature_670_residues
MKNNTLKMTTLCMLTIGISQFASAEATRATLPLLKAEQLPAWCDSNLKKIQQEISSFEKTPVKNDAAAAPILAKWDKIFG
HLEDFSGPIGLYSNVDPDAKLRKAAEDCEIKINQFHTDIFQNSKLYNVIKNTKATDPIDQKYRQDILDQFEDTGVQLEPA
KRARMKAILDELTKLEQEYNRNIRDNPEKLEFTPEEMKGLPESYISGLKKNTKGNYLLGFEYPEYRPFMELADNDDARKR
YQIAFTRRGTEQNLKLLKQAIDLRYELAQLFGKASYADWALKDRMAKTPEAVNKFLAEVQKTVAPLERKEVEELRAFKAQ
TLKTPLDKTEITRWSEAYWSEKLRKSKYQIDQEKLRDYFPTLAAQKWLFAISSDLYGIDFKPVKVKAWQDEVEYYDVVDK
KTGKLLGGLYMDKFPREGKYGHAAVWGVYGGSTLTNRLPISVLVTNFNRKGLNSDELETFVHEFGHALHGILSNTRYASQ
SGTSVERDFVEAPSQMYEEWARRKETLSKVADYCDPACPQVDDELIARLKAVHNYGRGLRYARQTLYAQYDMALHTADAL
KVKPLETWQKMEAVTALGYVPTTEFPGQFGHLMGGYQAGYYGYMWSEVLALDMLSAYGDNLNNPQVGQRYRQTILSQGSQ
KPAAELVKDFLGRDPDNKAFFNEITGQRVK

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=593, Percent_Identity=32.5463743676223, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI14149738, Length=591, Percent_Identity=31.1336717428088, Blast_Score=299, Evalue=5e-81,
Organism=Homo sapiens, GI156105687, Length=595, Percent_Identity=25.7142857142857, Blast_Score=160, Evalue=5e-39,
Organism=Escherichia coli, GI1789913, Length=621, Percent_Identity=31.8840579710145, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1787819, Length=592, Percent_Identity=24.8310810810811, Blast_Score=153, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=602, Percent_Identity=22.093023255814, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=644, Percent_Identity=28.416149068323, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=614, Percent_Identity=23.1270358306189, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21356111, Length=691, Percent_Identity=22.2865412445731, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI20129717, Length=585, Percent_Identity=24.1025641025641, Blast_Score=144, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76702; Mature: 76702

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNTLKMTTLCMLTIGISQFASAEATRATLPLLKAEQLPAWCDSNLKKIQQEISSFEKT
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PVKNDAAAAPILAKWDKIFGHLEDFSGPIGLYSNVDPDAKLRKAAEDCEIKINQFHTDIF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCEEHHHHHHHHH
QNSKLYNVIKNTKATDPIDQKYRQDILDQFEDTGVQLEPAKRARMKAILDELTKLEQEYN
HCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHC
RNIRDNPEKLEFTPEEMKGLPESYISGLKKNTKGNYLLGFEYPEYRPFMELADNDDARKR
CCCCCCCHHCCCCHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHH
YQIAFTRRGTEQNLKLLKQAIDLRYELAQLFGKASYADWALKDRMAKTPEAVNKFLAEVQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
KTVAPLERKEVEELRAFKAQTLKTPLDKTEITRWSEAYWSEKLRKSKYQIDQEKLRDYFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TLAAQKWLFAISSDLYGIDFKPVKVKAWQDEVEYYDVVDKKTGKLLGGLYMDKFPREGKY
HHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GHAAVWGVYGGSTLTNRLPISVLVTNFNRKGLNSDELETFVHEFGHALHGILSNTRYASQ
CCEEEEEECCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGTSVERDFVEAPSQMYEEWARRKETLSKVADYCDPACPQVDDELIARLKAVHNYGRGLR
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
YARQTLYAQYDMALHTADALKVKPLETWQKMEAVTALGYVPTTEFPGQFGHLMGGYQAGY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCH
YGYMWSEVLALDMLSAYGDNLNNPQVGQRYRQTILSQGSQKPAAELVKDFLGRDPDNKAF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
FNEITGQRVK
HHHHCCCCCC
>Mature Secondary Structure
MKNNTLKMTTLCMLTIGISQFASAEATRATLPLLKAEQLPAWCDSNLKKIQQEISSFEKT
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PVKNDAAAAPILAKWDKIFGHLEDFSGPIGLYSNVDPDAKLRKAAEDCEIKINQFHTDIF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCEEHHHHHHHHH
QNSKLYNVIKNTKATDPIDQKYRQDILDQFEDTGVQLEPAKRARMKAILDELTKLEQEYN
HCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHC
RNIRDNPEKLEFTPEEMKGLPESYISGLKKNTKGNYLLGFEYPEYRPFMELADNDDARKR
CCCCCCCHHCCCCHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCHHHHCCCCCHHHH
YQIAFTRRGTEQNLKLLKQAIDLRYELAQLFGKASYADWALKDRMAKTPEAVNKFLAEVQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
KTVAPLERKEVEELRAFKAQTLKTPLDKTEITRWSEAYWSEKLRKSKYQIDQEKLRDYFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TLAAQKWLFAISSDLYGIDFKPVKVKAWQDEVEYYDVVDKKTGKLLGGLYMDKFPREGKY
HHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GHAAVWGVYGGSTLTNRLPISVLVTNFNRKGLNSDELETFVHEFGHALHGILSNTRYASQ
CCEEEEEECCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGTSVERDFVEAPSQMYEEWARRKETLSKVADYCDPACPQVDDELIARLKAVHNYGRGLR
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
YARQTLYAQYDMALHTADALKVKPLETWQKMEAVTALGYVPTTEFPGQFGHLMGGYQAGY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCH
YGYMWSEVLALDMLSAYGDNLNNPQVGQRYRQTILSQGSQKPAAELVKDFLGRDPDNKAF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
FNEITGQRVK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]