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The map label for this gene is ung

Identifier: 213157129

GI number: 213157129

Start: 1896144

End: 1896857

Strand: Direct

Name: ung

Synonym: AB57_1812

Alternate gene names: 213157129

Gene position: 1896144-1896857 (Clockwise)

Preceding gene: 213157128

Following gene: 213157130

Centisome position: 46.81

GC content: 37.39

Gene sequence:

>714_bases
ATGCAATTAACTGAGCAACAGCAAGACAAACTCAGTAAAGTTCAATTAGAAGAAAGCTGGAAAAGATCATTAACTCCATT
TTTACTGAGTCCTTATATGGATAGTTTAAGAGACTTTTTGTTTCAACAAAAACAGGCTCAAAAAACCATATATCCACCAA
GTAAACAAATATTTAATGCTTTAAATATTACGCCGTTAGATCATGTGAAAGTCGTTATATTAGGGCAAGATCCATATCAT
GGTCCAAATCAGGCAAATGGCTTAAGTTTCTCGGTTCAAAGAGGGGTTGCATTACCACCATCTTTACGTAATATTTTTCA
TGAACTACATACAGATTTAGGGGTGCCGATTTCTCGTCATGGTGATTTAACCAAATGGGCGGAGCAAGGCGTACTTTTAT
TAAACAGTGTACTTACTGTAGAAGCAGGGCAACCCACATCACATCAAAAACAAGGCTGGGAAGAGTTTACTGACGCAGTA
ATTGATGTTTTAAATGAACAACGTGAACACATTGTTTTTATTTTATGGGGTGCTTATGCACAACGTAAAGGACAACGTAT
AAATAGAGAAAAACACTTGGTTTTAACTGCTGCACATCCATCGCCACTTGCGGCTAATCGTGGTGGTTTCTTTGGATGCA
AAGTGTTTTCCAAAACAAATCAATATTTGAAACAACATGGCATTGAGCCCATAGACTGGCAATTGGACGCATGA

Upstream 100 bases:

>100_bases
AAGGGATTAAGTTTCATAATCCGCATGTTAACTTACAAGTAGAAGTGTAAGTTAACTTCCTTTTGTTTGTAGAAATGAAA
ATTGATCTAGGATGACATTA

Downstream 100 bases:

>100_bases
TGAACTCTCCCAATGTAAATAGCTATCATCCGGATTTGGTAGTTGAAGAAGCGAAAAATGGTTGGCGTATTGTACGTTTG
AATCGACCTAAATCATTACA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNALNITPLDHVKVVILGQDPYH
GPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPISRHGDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAV
IDVLNEQREHIVFILWGAYAQRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA

Sequences:

>Translated_237_residues
MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNALNITPLDHVKVVILGQDPYH
GPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPISRHGDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAV
IDVLNEQREHIVFILWGAYAQRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA
>Mature_237_residues
MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNALNITPLDHVKVVILGQDPYH
GPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPISRHGDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAV
IDVLNEQREHIVFILWGAYAQRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=222, Percent_Identity=54.0540540540541, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI6224979, Length=222, Percent_Identity=54.0540540540541, Blast_Score=239, Evalue=1e-63,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=53.2110091743119, Blast_Score=230, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17556304, Length=235, Percent_Identity=45.1063829787234, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=41.7721518987342, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_ACIB3 (B7H3L4)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002325812.1
- ProteinModelPortal:   B7H3L4
- SMR:   B7H3L4
- GeneID:   7058865
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_001909
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26936; Mature: 26936

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 77-77

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNA
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LNITPLDHVKVVILGQDPYHGPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPISRH
CCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAVIDVLNEQREHIVFILWGAYA
CCHHHHHHCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHH
QRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA
HHHCHHCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MQLTEQQQDKLSKVQLEESWKRSLTPFLLSPYMDSLRDFLFQQKQAQKTIYPPSKQIFNA
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LNITPLDHVKVVILGQDPYHGPNQANGLSFSVQRGVALPPSLRNIFHELHTDLGVPISRH
CCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GDLTKWAEQGVLLLNSVLTVEAGQPTSHQKQGWEEFTDAVIDVLNEQREHIVFILWGAYA
CCHHHHHHCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHH
QRKGQRINREKHLVLTAAHPSPLAANRGGFFGCKVFSKTNQYLKQHGIEPIDWQLDA
HHHCHHCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA