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The map label for this gene is arsB [H]

Identifier: 213157009

GI number: 213157009

Start: 1774937

End: 1775911

Strand: Direct

Name: arsB [H]

Synonym: AB57_1687

Alternate gene names: 213157009

Gene position: 1774937-1775911 (Clockwise)

Preceding gene: 213157008

Following gene: 213157011

Centisome position: 43.82

GC content: 37.54

Gene sequence:

>975_bases
ATGGCTTTAGGTTTAGCGATTGGAGTTTTCTTTCCTCAGGCATCTGTATCTTTAAATGAATTAAGTGTAGATAACGTTAA
TATTCCAATCGCAATCGGTTTGGTTTTAATGATGTATCCGCCATTGGCAAAAGTGGACTATGCGGCTTTACCAGAAGTAT
TTAAGGATAAGAAAACCTTAACTTTATCGCTGGTACAAAACTGGATTATTGCTCCAGTTTTAATGTTTATCCTTGCGATT
GTTTTTTTGCATAACTATCCGGAGTATATGACTGGCCTTATTTTGATAGGCTTGGCACGTTGTATTGCAATGGTATTAGT
CTGGAATGGCTTAGCTTGTGGTGATAATCAATATGTTGCAGCTTTGGTCGCCTTTAACAGTATTTTTCAGATTTTATTTT
TTAGTACCTATGCATGGTTGTTCTTAACTTTCTTGCCGCCATATTTTGGTGTGGCAGGCCAAGTGATTGATGTCAATTTC
TGGACCATCACACATGCTGTTTTGGTGTACTTAGGTATTCCATTCTTAATGGGGTTCTTGACGCGTTTGATTTTAGTCAA
GTCGAAAGGGTTGGAATGGTATCAAACTAAATTTTTACCAAAGATCAGCCCGATTAGTTTAATTGCTTTACTTTTTACCA
TTGTGGCGATGTTTAGTTTAAAAGGTGGCGATGTGGTGAGCTTACCTTTAGATGTATTACGTATTGCGATTCCACTCACG
ATTTACTTTGTAGTGATGTTCTTTATTAGTTTCTTTATGAGTAAACGGATGGGGAATAACTACCCACGTACCACTGCTAT
TTCATTTACCGCGGCAGGTAATAACTTTGAGTTGGCTTTAGCTGTAGCTATTGCAACTTTTGGTTTAGCATCACCTGTAG
CATTTACCACAGTGATTGGACCATTGGTTGAAGTACCCGTTTTAATTTCACTCGTCACCGTTTCGCTTTGGTTAAAGAAA
AAGTATTACTCTTAA

Upstream 100 bases:

>100_bases
GTATTGAGCAAAATTAATCAATTCTTTCTTCGAGTAGAACATGACTAAACAAGGGCTTTCCTTTTTAGATCGAAACCTAA
CGCTATGGATTTTTATAGCA

Downstream 100 bases:

>100_bases
AATCGTAAAATTTATTTGAACTATTTTTTGCTAAAAATGACTTTAACAAAGTGCCTTTATATAGGCACTTTTTATTGCCT
AGCTTTTACACTTAGGTCAT

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MALGLAIGVFFPQASVSLNELSVDNVNIPIAIGLVLMMYPPLAKVDYAALPEVFKDKKTLTLSLVQNWIIAPVLMFILAI
VFLHNYPEYMTGLILIGLARCIAMVLVWNGLACGDNQYVAALVAFNSIFQILFFSTYAWLFLTFLPPYFGVAGQVIDVNF
WTITHAVLVYLGIPFLMGFLTRLILVKSKGLEWYQTKFLPKISPISLIALLFTIVAMFSLKGGDVVSLPLDVLRIAIPLT
IYFVVMFFISFFMSKRMGNNYPRTTAISFTAAGNNFELALAVAIATFGLASPVAFTTVIGPLVEVPVLISLVTVSLWLKK
KYYS

Sequences:

>Translated_324_residues
MALGLAIGVFFPQASVSLNELSVDNVNIPIAIGLVLMMYPPLAKVDYAALPEVFKDKKTLTLSLVQNWIIAPVLMFILAI
VFLHNYPEYMTGLILIGLARCIAMVLVWNGLACGDNQYVAALVAFNSIFQILFFSTYAWLFLTFLPPYFGVAGQVIDVNF
WTITHAVLVYLGIPFLMGFLTRLILVKSKGLEWYQTKFLPKISPISLIALLFTIVAMFSLKGGDVVSLPLDVLRIAIPLT
IYFVVMFFISFFMSKRMGNNYPRTTAISFTAAGNNFELALAVAIATFGLASPVAFTTVIGPLVEVPVLISLVTVSLWLKK
KYYS
>Mature_323_residues
ALGLAIGVFFPQASVSLNELSVDNVNIPIAIGLVLMMYPPLAKVDYAALPEVFKDKKTLTLSLVQNWIIAPVLMFILAIV
FLHNYPEYMTGLILIGLARCIAMVLVWNGLACGDNQYVAALVAFNSIFQILFFSTYAWLFLTFLPPYFGVAGQVIDVNFW
TITHAVLVYLGIPFLMGFLTRLILVKSKGLEWYQTKFLPKISPISLIALLFTIVAMFSLKGGDVVSLPLDVLRIAIPLTI
YFVVMFFISFFMSKRMGNNYPRTTAISFTAAGNNFELALAVAIATFGLASPVAFTTVIGPLVEVPVLISLVTVSLWLKKK
YYS

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=329, Percent_Identity=32.5227963525836, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 35813; Mature: 35681

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGLAIGVFFPQASVSLNELSVDNVNIPIAIGLVLMMYPPLAKVDYAALPEVFKDKKTL
CCCHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHCCCHHH
TLSLVQNWIIAPVLMFILAIVFLHNYPEYMTGLILIGLARCIAMVLVWNGLACGDNQYVA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ALVAFNSIFQILFFSTYAWLFLTFLPPYFGVAGQVIDVNFWTITHAVLVYLGIPFLMGFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
TRLILVKSKGLEWYQTKFLPKISPISLIALLFTIVAMFSLKGGDVVSLPLDVLRIAIPLT
HHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
IYFVVMFFISFFMSKRMGNNYPRTTAISFTAAGNNFELALAVAIATFGLASPVAFTTVIG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHH
PLVEVPVLISLVTVSLWLKKKYYS
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALGLAIGVFFPQASVSLNELSVDNVNIPIAIGLVLMMYPPLAKVDYAALPEVFKDKKTL
CCHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHCCCHHH
TLSLVQNWIIAPVLMFILAIVFLHNYPEYMTGLILIGLARCIAMVLVWNGLACGDNQYVA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ALVAFNSIFQILFFSTYAWLFLTFLPPYFGVAGQVIDVNFWTITHAVLVYLGIPFLMGFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
TRLILVKSKGLEWYQTKFLPKISPISLIALLFTIVAMFSLKGGDVVSLPLDVLRIAIPLT
HHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
IYFVVMFFISFFMSKRMGNNYPRTTAISFTAAGNNFELALAVAIATFGLASPVAFTTVIG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHH
PLVEVPVLISLVTVSLWLKKKYYS
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]