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The map label for this gene is yngJ [H]

Identifier: 213156915

GI number: 213156915

Start: 1671923

End: 1673077

Strand: Direct

Name: yngJ [H]

Synonym: AB57_1586

Alternate gene names: 213156915

Gene position: 1671923-1673077 (Clockwise)

Preceding gene: 213156908

Following gene: 213156916

Centisome position: 41.28

GC content: 43.46

Gene sequence:

>1155_bases
ATGATCCGTGATGAAGGGATGTTGGAGCAGTTACTTTCAACAATTCGAGATTTTGTAAAAAATGAATTGATCCCTCGTGA
AAACGAAGTGGTAGAGAAAGACAAAATTCCAGATGACATTGTGCAGCAAATGCGTGAACTTGGTTTGTTCGGTCTTACAA
TTCCCGAAGAATATGGTGGCTTAGGCATCACTATGGAAGAGGAAGTCAGAGTTGCATTTGAACTTGGACAAACTTCACCG
GCTTTTCGTTCTTTAATTGGTACTAATAACGGTATTGGCTCAAGTGCAATTTTGATTGATGGCACAGAAGAGCAAAAGCA
GAAATATTTACCACGTTACGCAAGTGGCGAAATTATTGGTTCATTTTGTTTAACCGAGCCTGAATCTGGCTCTGACGCTG
CCTCTTTAAAAACCAGTGCCGTAAAAGATGGCGATTTTTATGTGTTAAATGGCACCAAACGTTTTATTACCAATGCACCC
CATGCTGCAACTTTCACTGTAATGGCTCGGACAAATCCTGAAATTAAAGGGTCGGGTGGCATTTCAGCTTTTTTAGTTGA
GGCCAATACGCCGGGCATTACGTTGGGCAAAATTGACCAAAAAATGGGGCAAAAGGGTTCACATACCTGTGATGTGATTT
TTGAAAATTGCCGTGTGCCTGCTTCTGCACTGATTGGTGGGGTAGAAGGTGTCGGTTTTAAAACGGCCATGAAAGTGCTT
GATAAAGGGCGTTTGCATATTGGTGCCTATAGCGTAGGTGTTGCCGAACGCATGTTAAACGACGCACTGCACTATGCGAT
TGAGCGTAAGCAGTTTGGTCAACCTATTGCAAACTTCCAGCTTATTCAAGCCATGCTTGCCGACTCAAAAGCCGAGATTT
ACGCAGCTAAATGTATGGTCCTAGATGCAGCTCGCCGCCGTGATAATGGTGAAAACATTAGCACGGAAGCTTCTTGCGCA
AAAATGTTTGCGACCGAAATGTGTGGTCGTGTTGCTGACCGCTGTGTACAGATTCACGGTGGTGCGGGCTATATCAGTGA
ATATGCCATCGAGCGTTTTTATCGAGATGTGCGTTTGTTCCGTTTATATGAAGGAACCACGCAAGTTCAACAACTTATTA
TTGCCAAAAACATGATTAGGGAAGCTACAGCCTAA

Upstream 100 bases:

>100_bases
TGAAACACATCCGCAGTAAACAAGATTTAAAACATGGTATCCAGATTAGCTGGAGATGGCTGATGGATACGATGGAAATA
CATAAAAAGGGAGATCACAG

Downstream 100 bases:

>100_bases
TAAAAAATCAAATGCCATGAGGCATGGGATGCCTCATGTTCCTTCTGAGGATATGGACATGACAACAAAGACTGTTACAG
AGAATATGAGTAGCACTGAA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MIRDEGMLEQLLSTIRDFVKNELIPRENEVVEKDKIPDDIVQQMRELGLFGLTIPEEYGGLGITMEEEVRVAFELGQTSP
AFRSLIGTNNGIGSSAILIDGTEEQKQKYLPRYASGEIIGSFCLTEPESGSDAASLKTSAVKDGDFYVLNGTKRFITNAP
HAATFTVMARTNPEIKGSGGISAFLVEANTPGITLGKIDQKMGQKGSHTCDVIFENCRVPASALIGGVEGVGFKTAMKVL
DKGRLHIGAYSVGVAERMLNDALHYAIERKQFGQPIANFQLIQAMLADSKAEIYAAKCMVLDAARRRDNGENISTEASCA
KMFATEMCGRVADRCVQIHGGAGYISEYAIERFYRDVRLFRLYEGTTQVQQLIIAKNMIREATA

Sequences:

>Translated_384_residues
MIRDEGMLEQLLSTIRDFVKNELIPRENEVVEKDKIPDDIVQQMRELGLFGLTIPEEYGGLGITMEEEVRVAFELGQTSP
AFRSLIGTNNGIGSSAILIDGTEEQKQKYLPRYASGEIIGSFCLTEPESGSDAASLKTSAVKDGDFYVLNGTKRFITNAP
HAATFTVMARTNPEIKGSGGISAFLVEANTPGITLGKIDQKMGQKGSHTCDVIFENCRVPASALIGGVEGVGFKTAMKVL
DKGRLHIGAYSVGVAERMLNDALHYAIERKQFGQPIANFQLIQAMLADSKAEIYAAKCMVLDAARRRDNGENISTEASCA
KMFATEMCGRVADRCVQIHGGAGYISEYAIERFYRDVRLFRLYEGTTQVQQLIIAKNMIREATA
>Mature_384_residues
MIRDEGMLEQLLSTIRDFVKNELIPRENEVVEKDKIPDDIVQQMRELGLFGLTIPEEYGGLGITMEEEVRVAFELGQTSP
AFRSLIGTNNGIGSSAILIDGTEEQKQKYLPRYASGEIIGSFCLTEPESGSDAASLKTSAVKDGDFYVLNGTKRFITNAP
HAATFTVMARTNPEIKGSGGISAFLVEANTPGITLGKIDQKMGQKGSHTCDVIFENCRVPASALIGGVEGVGFKTAMKVL
DKGRLHIGAYSVGVAERMLNDALHYAIERKQFGQPIANFQLIQAMLADSKAEIYAAKCMVLDAARRRDNGENISTEASCA
KMFATEMCGRVADRCVQIHGGAGYISEYAIERFYRDVRLFRLYEGTTQVQQLIIAKNMIREATA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=39.7849462365591, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=36.7724867724868, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4557235, Length=376, Percent_Identity=38.8297872340425, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI76496475, Length=376, Percent_Identity=38.8297872340425, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI21361497, Length=384, Percent_Identity=38.5416666666667, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=37.2654155495979, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=37.2654155495979, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI226958412, Length=370, Percent_Identity=34.5945945945946, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI7656849, Length=369, Percent_Identity=37.6693766937669, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=35.693215339233, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=35.2, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=33.2439678284182, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=33.2409972299169, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI211971008, Length=392, Percent_Identity=28.8265306122449, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI48976061, Length=392, Percent_Identity=28.8265306122449, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI38505218, Length=398, Percent_Identity=27.8894472361809, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI156104864, Length=311, Percent_Identity=25.7234726688103, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI156104866, Length=311, Percent_Identity=25.7234726688103, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=29.5212765957447, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=29.973474801061, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081702, Length=293, Percent_Identity=30.3754266211604, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082384, Length=282, Percent_Identity=26.5957446808511, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=40.1639344262295, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=366, Percent_Identity=40.1639344262295, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17506239, Length=363, Percent_Identity=39.6694214876033, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17534899, Length=366, Percent_Identity=38.5245901639344, Blast_Score=263, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17570075, Length=372, Percent_Identity=37.3655913978495, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71985184, Length=375, Percent_Identity=38.4, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=36.096256684492, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=32.7127659574468, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=316, Percent_Identity=38.9240506329114, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=322, Percent_Identity=37.5776397515528, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=42.2413793103448, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=371, Percent_Identity=31.266846361186, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=34.6863468634686, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=378, Percent_Identity=27.5132275132275, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17505929, Length=384, Percent_Identity=27.6041666666667, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.4398340248963, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=388, Percent_Identity=29.1237113402062, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=30.8988764044944, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=275, Percent_Identity=26.5454545454545, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=275, Percent_Identity=26.5454545454545, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540842, Length=285, Percent_Identity=27.0175438596491, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=39.2, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=38.3378016085791, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=38.0208333333333, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=37.1967654986523, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=37.17277486911, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=32.1052631578947, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19920834, Length=365, Percent_Identity=32.0547945205479, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24652780, Length=352, Percent_Identity=23.2954545454545, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42034; Mature: 42034

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDEGMLEQLLSTIRDFVKNELIPRENEVVEKDKIPDDIVQQMRELGLFGLTIPEEYGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEEECCHHHCC
LGITMEEEVRVAFELGQTSPAFRSLIGTNNGIGSSAILIDGTEEQKQKYLPRYASGEIIG
CCCEEHHHHHEEECCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCEEE
SFCLTEPESGSDAASLKTSAVKDGDFYVLNGTKRFITNAPHAATFTVMARTNPEIKGSGG
HHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHCCCCCCEEEEEEEECCCCCCCCCC
ISAFLVEANTPGITLGKIDQKMGQKGSHTCDVIFENCRVPASALIGGVEGVGFKTAMKVL
CEEEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHH
DKGRLHIGAYSVGVAERMLNDALHYAIERKQFGQPIANFQLIQAMLADSKAEIYAAKCMV
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHH
LDAARRRDNGENISTEASCAKMFATEMCGRVADRCVQIHGGAGYISEYAIERFYRDVRLF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHH
RLYEGTTQVQQLIIAKNMIREATA
HHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRDEGMLEQLLSTIRDFVKNELIPRENEVVEKDKIPDDIVQQMRELGLFGLTIPEEYGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEEECCHHHCC
LGITMEEEVRVAFELGQTSPAFRSLIGTNNGIGSSAILIDGTEEQKQKYLPRYASGEIIG
CCCEEHHHHHEEECCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCEEE
SFCLTEPESGSDAASLKTSAVKDGDFYVLNGTKRFITNAPHAATFTVMARTNPEIKGSGG
HHCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHCCCCCCEEEEEEEECCCCCCCCCC
ISAFLVEANTPGITLGKIDQKMGQKGSHTCDVIFENCRVPASALIGGVEGVGFKTAMKVL
CEEEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHH
DKGRLHIGAYSVGVAERMLNDALHYAIERKQFGQPIANFQLIQAMLADSKAEIYAAKCMV
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHH
LDAARRRDNGENISTEASCAKMFATEMCGRVADRCVQIHGGAGYISEYAIERFYRDVRLF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHH
RLYEGTTQVQQLIIAKNMIREATA
HHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]